Ascorbic acid inhibits vascular remodeling induced by mental stress in overweight/obese men

Batista, Gabriel M. S.; Rocha, Helena; Storch, Amanda Sampaio; Garcia, Vinicius P; Teixeira, G.F.; Mentzinger, Juliana; Gomes, Erika Alvarenga Corrêa; Velasco, Larissa Lírio; Nóbrega, Antônio Cláudio Lucas da; Rocha, Nazareth de Novaes

doi:10.1016/j.lfs.2020.117554

Cited by 9 publications

(8 citation statements)

References 53 publications

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“…Ascorbic acid is a water-soluble vitamin known to neutralize ROS-RNS, and its venous administration was able to prolong the PT and reduce fibrinogen response to stress task in overweight and obese men. Previous studies published by our group 38 , 39 and others 40 reinforce that finding, demonstrating that ascorbic acid prevented redox imbalance and reduced vascular remodeling in overweight and obese men 38 , 39 . Also, it was already demonstrated that fibrinogen is a vulnerable target for oxidant attack 41 .…”

Section: Discussionsupporting

confidence: 76%

“…The present study did not measure redox homeostasis parameters nor catecholamines levels. However, studies from our group and others 38 , 40 have shown the effects of ascorbic acid on oxidative stress after exposure to a mental stress task. Considering those aspects already shown, the present study focuses on studying whether the ascorbic acid, a well-known antioxidant, is able to blunt hemostatic responses to stress.…”

Section: Discussionmentioning

confidence: 83%

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Ascorbic acid prevents stress-induced hypercoagulability in overweight and obese individuals

Rocha,

Velasco,

Batista

et al. 2024

Sci Rep

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Ascorbic acid (AA) may contribute to restoring hemostatic balance after mental stress (MS) in overweight/obese adults. We aimed to determine the effects of AA administration on hemostatic responses to MS in overweight/obese men. Fourteen overweight/obesity men (27 ± 7 years; BMI: 29.7 ± 2.6 kg m−2) performed the Stroop color-word stress task for 5 min after non-simultaneous infusion of placebo (PL, 0.9% NaCl) and AA (3 g). Blood was collected at baseline, during MS, and 60 min after MS to measure: activated partial thromboplastin time, prothrombin time, and fibrinogen concentration, by coagulometer; platelet-derived microvesicles (PMV, mv/μL), by flow cytometry; nitrite (μM), by chemiluminescence. In PL session, MS led to decreases in PTs (stress, p = 0.03; 60 min, p < 0.001), PT-INR (stress, p < 0.001; 60 min, p < 0.01), aPTTs (60 min, p = 0.03), aPTT ratio (60 min, p = 0.04) and fibrinogen (60 min, p = 0.04), while increased PT activity (60 min, p = 0.01) when compared to baseline. Furthermore, AA increased PTs (60 min, p < 0.001), PT-INR (60 min, p = 0.03) and decreased PT activity (60 min, p < 0.001) and fibrinogen (stress, p = 0.04) when compared to PL. Nitrite was increased in response to stress during AA session (p < 0.001 vs PL). There was no difference in PMV. Ascorbic acid prevented the impaired hemostatic profile and improved nitrite response to stress in the overweight and obese adults.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 83%

Ascorbic acid prevents stress-induced hypercoagulability in overweight and obese individuals

Rocha,

Velasco,

Batista

et al. 2024

Sci Rep

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“…Results showed that antioxidant supplementation improved antioxidant-oxidant balance by increasing antioxidant status and reducing oxidative stress biomarkers, namely, F(2)-isoprostanes and F(2)-isoprostane metabolites, but did not affect the inflammatory markers measured [200]. Vitamin C intravenous infusions in overweight or obese grade I subjects reduced protein carbonylation, one of the most harmful irreversible oxidative protein modifications, and a major hallmark of oxidative stress-related disorders [201]. Conjugated linoleic acid supplementation plus vitamin E improved insulin resistance, lipid disturbances, oxidative stress as total antioxidant capacity increased, and MDA significantly decreased in obese patients with NAFLD [202].…”

Section: Obesitymentioning

confidence: 97%

The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors

et al. 2021

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Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.

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“…An allied report 35 showed that ascorbic acid is not only able to inhibit vascular remodeling, but also yields more effective weight loss than not when assessed in a controlled trial of mentally stressed overweight/obese men. Its presence was also linked to observed reductions in harmful oxidative stresses, 36,37 and supported other evidence of successful weight loss in the face of vitamin C ingestion when compared to a control situation.…”

Section: Resultsmentioning

confidence: 99%

Vitamin C and obesity: problems and solutions

Marks¹

2021

AOWMC

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Obesity, a largely intractable health condition with incalculable health and financial and social costs and ramifications remains an immense challenge to mitigate effectively. Multiple interventions to offset obesity, and to mitigate its negative impact, while studied and implemented for many years, have generally failed to eliminate this growing global epidemic. Alternately, interventions that can limit the onset of obesity, or help to reduce this where present, including efforts to contain pain, depression, and lack of energy, would appear of high significance. Studied for over 40 years, various anti oxidants are proving to be of possible adjunctive benefit in efforts to reduce excess weight, and associated inflammatory responses, pain, and depression that are encountered by overweight persons. This mini review discusses some findings regarding vitamin C or ascorbic acid, a key ingredient of fruits and vegetables, and whether more emphasis on ensuring adequate vitamin C intake has a possible role in attenuating selected correlates of the global obesity burden. Extracted from current literature, it is concluded that this is a field of significant promise, but one requiring more insightful research, multiple intervention approaches, and dedicated collaborators.

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Ascorbic acid inhibits vascular remodeling induced by mental stress in overweight/obese men

Cited by 9 publications

References 53 publications

Ascorbic acid prevents stress-induced hypercoagulability in overweight and obese individuals

Ascorbic acid prevents stress-induced hypercoagulability in overweight and obese individuals

The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors

Vitamin C and obesity: problems and solutions

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