Ascorbic acid therapy: A potential strategy against comorbid depression-like behavior in streptozotocin-nicotinamide-induced diabetic rats

Shivavedi, Naveen; Tej, Gullanki Naga Venkata Charan; Neogi, Kaushik; Nayak, Prasant

doi:10.1016/j.biopha.2018.10.070

Cited by 29 publications

(15 citation statements)

References 82 publications

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“…Similar outcomes also have been observed for several molecules from medicinal and edible plants. Naveen Shivaved et al revealed that ascorbic acid, which is abundant in fresh fruits and vegetables, ameliorates oxidative stress and inflammatory response by reducing catalase levels and increasing SOD content, CAT activity, and IL-10 levels in the prefrontal cortex of diabetic rats, indicating the therapeutic potential of ascorbic acid against diabetes comorbid depression (Shivavedi et al, 2019). In addition, studies by Zhou et al showed that carotenoids, including astaxanthin and zeaxanthin, downregulate IL-6 and IL-1β in the hippocampus and protect neurons from hyperglycemic damage, implicating that depression can be prevented by astaxanthin and zeaxanthin through the inhibition of hippocampal inflammation in diabetic mice (Zhou et al, 2017;Zhou et al, 2018).…”

Section: Tcm and Natural Products With Antioxidative Stress And Inflammation Effects Against Comorbid Depression And Diabetesmentioning

confidence: 99%

Depression with Comorbid Diabetes: What Evidence Exists for Treatments Using Traditional Chinese Medicine and Natural Products?

Tian

et al. 2021

Front. Pharmacol.

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Comorbidity between diabetes mellitus (DM) and depression, two chronic and devastating diseases spreading worldwide, has been confirmed by a large body of epidemiological and clinical studies. Due to the bidirectional relationship between DM and depression, this comorbidity leads to poorer outcomes in both conditions. Given the adverse effects and limited effectiveness of the existing therapies for depression associated with diabetes, the development of novel therapeutic drugs with more potency and fewer side effects is still the most important goal. Hence, many researchers have made great efforts to investigate the potential usefulness of traditional Chinese medicine (TCM) and natural products, including natural extracts and purified compounds, in the treatment of comorbid depression in diabetes. Here, we reviewed the related literature on TCM and natural products that can remedy the comorbidity of diabetes and depression and presented them on the basis of their mechanism of action, focusing on shared risk factors, including insulin resistance, oxidative stress and inflammation, and nervous disturbances. In short, this review suggests that TCM and natural products could expand the therapeutic alternatives to ameliorate the association between DM and depressive disorders.

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Section: Tcm and Natural Products With Antioxidative Stress And Inflammation Effects Against Comorbid Depression And Diabetesmentioning

confidence: 99%

Depression with Comorbid Diabetes: What Evidence Exists for Treatments Using Traditional Chinese Medicine and Natural Products?

Tian

et al. 2021

Front. Pharmacol.

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“…Ascorbic acid, a natural antioxidant, was proposed as a potential strategy against comorbid depression-like behavior in diabetic rats. It was revealed that ascorbic acid treatment reduced the depressive behavior in STZ-nicotinamide-induced diabetic rats [55]. Also, it was demonstrated that ascorbic acid reduced oxidative stress, hyperglycemia, and inflammation [55, 56]; on the other hand, positive results with Aloe vera treatment were found, which has antioxidative, neuroprotective, and antidiabetic effects.…”

Section: Introductionmentioning

confidence: 99%

“…It was revealed that ascorbic acid treatment reduced the depressive behavior in STZ-nicotinamide-induced diabetic rats [55]. Also, it was demonstrated that ascorbic acid reduced oxidative stress, hyperglycemia, and inflammation [55, 56]; on the other hand, positive results with Aloe vera treatment were found, which has antioxidative, neuroprotective, and antidiabetic effects. The study revealed that Aloe vera displayed antidepressant effects in STZ-induced diabetic rats, and these effects were suggested to be related to hypoglycemic and antioxidant properties of Aloe vera in the hippocampus [56].…”

Section: Introductionmentioning

confidence: 99%

Relationship of Oxidative Stress as a Link between Diabetes Mellitus and Major Depressive Disorder

Réus

Carlessi

Silva

et al. 2019

Oxidative Medicine and Cellular Longevity

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Both conditions, major depressive disorder (MDD) and diabetes mellitus (DM) are chronic and disabling diseases that affect a very significant percentage of the world’s population. Studies have been shown that patients with DM are more susceptible to develop depression, when compared to the general population. The opposite also happens; MDD could be a risk factor for DM development. Some mechanisms have been proposed to explain the pathophysiological mechanisms involved with these conditions, such as excess of glucocorticoids, hyperglycemia, insulin resistance, and inflammation. These processes can lead to an increase in damage to biomolecules and a decrease in antioxidant defense capacity, leading to oxidative stress.

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“…A more detailed analysis of the mechanisms leading to low plasma and RBC ascorbate levels in diabetics and its consequences could lead to new therapeutic approaches for the adequate supply of this important antioxidant. Further research could justify the frequently demanded higher vitamin C requirements in diabetics [48] and thus contribute to a better supply and subsequently to a reduction of co-morbidities and OS as recently described in diabetic rats [49]. Recently, it has been shown that adolescents with type 1 diabetes have a reduced RBC-Glut-1 [50].…”

Section: Discussionmentioning

confidence: 99%

Glut-1 explains the evolutionary advantage of the loss of endogenous vitamin C-synthesis

Hornung

Biesalski

2019

Evolution, Medicine, and Public Health

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Introduction During evolution, some species including humans, monkeys and fruit bats lost the ability for ascorbic acid (AA) biosynthesis due to inactivation of the enzyme l-gulono-lactone oxidase (GLO) and subsequently became dependent on dietary vitamin C. There are four current hypotheses in relation to the benefit of vitamin C dependence in the context of adaptation and reproduction. Here we advance and test a new ‘electron transfer hypothesis’, which focusses on the role of the expression of glucose transporter 1 (Glut-1) in red blood cells (RBCs) in recycling vitamin C, thereby increasing the efficiency of micronutrient uptake. Methods To evaluate the benefit of Glut-1 expression, we determined vitamin C uptake into RBCs and potential release from two different species, humans with l-Gulono-lactone-oxidase (GLO-loss) and pigs with functional GLO. Results The oxidized form of vitamin C (dehydroascorbate, DHA) was transported into human RBCs via Glut-1. There was no transport of either the reduced (AA) or the oxidized vitamin in pig erythrocytes. Conclusion We propose that the transport of vitamin C increases an intracellular electron pool, which transfers electrons from intracellular ascorbate to extracellular substances like ascorbyl free radical or DHA, resulting in 100-fold smaller daily requirement of this essential redox sensitive micronutrient. This would be an advantage during seasonal changes of the availability from food and may be the key for the survival of individuals without vitamin C biosynthesis. Lay Summary 40 million years ago some individuals lost the ability to synthesize vitamin C. Why did they survive such as humans until now? Individuals with a specific glucose transporter Glut-1 on their erythrocytes which transports vitamin C need less and are protected from scarcity due to seasons and food competitors.

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Ascorbic acid therapy: A potential strategy against comorbid depression-like behavior in streptozotocin-nicotinamide-induced diabetic rats

Cited by 29 publications

References 82 publications

Depression with Comorbid Diabetes: What Evidence Exists for Treatments Using Traditional Chinese Medicine and Natural Products?

Depression with Comorbid Diabetes: What Evidence Exists for Treatments Using Traditional Chinese Medicine and Natural Products?

Relationship of Oxidative Stress as a Link between Diabetes Mellitus and Major Depressive Disorder

Glut-1 explains the evolutionary advantage of the loss of endogenous vitamin C-synthesis

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