Relationship of Oxidative Stress as a Link between Diabetes Mellitus and Major Depressive Disorder

Réus, Gislaine Z.; Carlessi, Anelise S.; Silva, Ritele H.; Ceretta, Luciane Bisognin; Quevedo, João

doi:10.1155/2019/8637970

Cited by 54 publications

(40 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mitochondrion is an organelle that supplies a large amount of energy using an electron transport chain and oxidative phosphorylation and contributes to cellular activities. However, this process also generates reactive oxygen species (ROS) which causes oxidative damage to mitochondrial lipids, DNA, and proteins [5, 6]. Oxidative stress is considered as a major environmental factor in aging [29].…”

Section: Discussionmentioning

confidence: 99%

“…Excess ROS can be utilized by endogenous antioxidant such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and other enzymes. The overproduction of ROS is related to oxidative stress and can cause damage to biological molecules [5, 6]. Various literatures reported that natural or synthetic antioxidants can be used to counter harmful effects of oxidative stress [7, 8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Structure Characterization and Action Mechanism of an Antiaging New Compound from Gastrodia elata Blume

Farooq

Pan

Yang

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

A new compound, bis(4-hydroxybenzyl)ether mono-β-L-galactopyranoside (1), was isolated from the rhizome of Gastrodia elata Blume. Its structure was elucidated using extensive spectroscopic analysis, including 1D and 2D NMR, HR-ESI-TOF-MS, and chemical derivatization. Compound 1 extended the replicative lifespan of K6001 and the chronological lifespan of YOM36 yeast strains. To understand the mechanism of action, oxidative stress assessment, reactive oxygen species (ROS) and malondialdehyde (MDA) levels, catalase (CAT) and total glutathione peroxidase (GPx) activity assays, and replicative lifespan assay of sod1, sod2, uth1, and skn7 yeast mutant strains were performed. Results indicated the significant increase in the survival rate of yeast under oxidative stress after treatment with 1. ROS and MDA levels were reduced significantly. Meanwhile, the activity of CAT and GPx was significantly increased. The lifespan of sod1, sod2, uth1, and skn7 mutants of K6001 was not affected by 1. Furthermore, we investigated the gene expression related to longevity after administrating 1. The significant increase of Sir2 and reduction of Uth1 gene expression in the 1-treated group were observed. These results indicated that antioxidative stress played an important role in the antiaging effect of 1; Sir2 and Uth1 genes were involved in antiaging effects of 1.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structure Characterization and Action Mechanism of an Antiaging New Compound from Gastrodia elata Blume

Farooq

Pan

Yang

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Risk factors for depression include adverse life events, external environmental stress, cognitive impairment, depressed parents, social dysfunction, and being female (Hammen, 2018). Patients with malignant tumors, diabetes, chronic physical pain, or cardiovascular and cerebrovascular diseases also had higher rates of depression than healthy controls (Bortolato et al, 2017; Hare et al, 2014; Kales, Maixner & Mellow, 2005; Réus et al, 2019; Sheng et al, 2017). Thus, both structural and functional disorders, especially in the brain, may contribute to depression.…”

Section: Introductionmentioning

confidence: 96%

Brain structural and functional changes in patients with major depressive disorder: a literature review

Dai

Zhou

et al. 2019

PeerJ

View full text Add to dashboard Cite

Depression is a mental disorder characterized by low mood and anhedonia that involves abnormalities in multiple brain regions and networks. Epidemiological studies demonstrated that depression has become one of the most important diseases affecting human health and longevity. The pathogenesis of the disease has not been fully elucidated. The clinical effect of treatment is not satisfactory in many cases. Neuroimaging studies have provided rich and valuable evidence that psychological symptoms and behavioral deficits in patients with depression are closely related to structural and functional abnormalities in specific areas of the brain. There were morphological differences in several brain regions, including the frontal lobe, temporal lobe, and limbic system, in people with depression compared to healthy people. In addition, people with depression also had abnormal functional connectivity to the default mode network, the central executive network, and the salience network. These findings provide an opportunity to re-understand the biological mechanisms of depression. In the future, magnetic resonance imaging (MRI) may serve as an important auxiliary tool for psychiatrists in the process of early and accurate diagnosis of depression and finding the appropriate treatment target for each patient to optimize clinical response.

show abstract

“…Oxidative stress is defined as an imbalance between oxidation and anti-oxidation in the body where the endogenous antioxidants are not able to counteract the oxidative dysregulation of lipids, protein, DNA and cellular structures [7]. Oxidative stress has been found to be closely related to metabolism in recent years [8,9].…”

mentioning

confidence: 99%

NRF2 deficiency increases obesity susceptibility in a mouse menopausal model

Huang

Cong

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

The risk of metabolic abnormalities in menopausal women increases significantly due to the decline in estrogen level. Nuclear factor E2-related factor 2 (NRF2) is an important oxidative stress sensor that plays regulatory role in energy metabolism. Therefore, an ovariectomized menopausal model in Nrf2-knockout (KO) mice was applied to evaluate the effect of Nrf2 deficiency on metabolism in menopausal females. The mice were divided into four groups according to their genotypes and treatments. Blood samples and bodyweights were obtained preoperatively and in the first to ninth postoperative weeks after overnight fasting. Serum levels of triglycerides (TG), total cholesterol (T-CHO), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and glucose (GLU) were measured at postoperative weeks 0, 1, 3, 5, 7, and 9. Neurotransmitter dopamine (DA) and serotonin (5-HT) was analyzed in brain tissues after sacrifice at postoperative week 9. The results demonstrated that, compared with the corresponding wild-type (WT) mice, KO ovariectomized mice had a greater bodyweight gain (P<0.01). Serum analysis showed that the serum GLU, T-CHO, and TG were significantly lower (P<0.05) but LDL was significantly higher (P<0.05) in the KO control mice than that in WT control mice. However, different from the WT counterparts, an increase in blood GLU level (P<0.05), unchanged T-CHO, TG, and HDL levels, and a significant reduction in LDL (P<0.01) was found in the KO ovariectomized mice. In addition, the level of 5-HT was significantly reduced (P<0.05) in the KO mice after ovariectomy. In conclusion, the combination of Nrf2 deletion and a decline in estrogen level induced a significant increase in bodyweight, which may be associated with their altered glucose and LDL metabolism and decreased 5-HT levels. From a clinical perspective, women with antioxidant defense deficiency may have an increased risk of metabolic abnormalities after menopause. Competing interests:The authors have declared that no competing interests exist.serum MDA levels increased in the WT-OVX and KO-CON groups, but decreased in the KO-OVX group, though no statistical significance was reached yet (Fig 2). Body weight changes in different groups of miceBody weight curves prepared by weighing each group of mice weekly showed that weight gain occurred in the WT-OVX and KO-OVX groups relative to the WT-CON and KO-CON groups (Fig 3b). No significant difference of the weight gain rate was found between the WT-CON and KO-CON groups, but OVX groups had increased weight compared to the counterpart CON groups (Fig 3b and 3a, P < 0.05 and P < 0.01). By calculating the rate of weight gain from the preoperative time to postoperative week 9 in different groups, we found that the weight gain rates of the KO-OVX was significantly higher than that in the corresponding KO-CON and WT-CON groups after postoperative week 4 (Fig 3b), and the weight gain rate of KO-OVX was the greatest and was significantly different from the WT-CON and KO-CON group (WT-CON 6.02% ± 2.95%, WT-OVX 18.55% ...

show abstract

Relationship of Oxidative Stress as a Link between Diabetes Mellitus and Major Depressive Disorder

Cited by 54 publications

References 60 publications

Structure Characterization and Action Mechanism of an Antiaging New Compound from Gastrodia elata Blume

Structure Characterization and Action Mechanism of an Antiaging New Compound from Gastrodia elata Blume

Brain structural and functional changes in patients with major depressive disorder: a literature review

NRF2 deficiency increases obesity susceptibility in a mouse menopausal model

Contact Info

Product

Resources

About