Ascorbic acid treatment, similarly to fluoxetine, reverses depressive-like behavior and brain oxidative damage induced by chronic unpredictable stress

Oxidative Stress and Major Depression

“…Ascorbic acid, an antioxidant, has negative correlation with the major depression is a finding well-established [33]. Even in the present scenario ascorbic acid has been found to be effective in the mouse model of depression [34]. In a study done in the paediatric age group also the ascorbic acid treatment as an adjunct to fluoxetine has been found to be effective [35].…”

Chronic stress impacts the cardiovascular system: animal models and clinical outcomes

“…Many adverse effects of psychological disorders, including endothelial dysfunction, accelerated infectious disease progression, and an overactivity of the autoimmune/inflammatory systems, have all been related to alterations to the circulating profile of cytokines (80,232). For instance, early childhood abuse in girls increases the risk of diabetes and cardiovascular diseases, possibly through immune and chronic inflammatory dysregulation (30).…”

Study of antidepressant effects of grape seed oil in male mice using tail suspension and forced swim tests

“…In this study, injection of fluoxetine (10 mg/kg) to mice under chronic stress significantly decreased the immobility time compared to the group under chronic stress receiving normal saline. Moretti et al consistently showed that intraperitoneal injection of fluoxetine (10 mg/kg) to mice under chronic unpredictable stress significantly decreased the immobility time in forced swim test and tail suspension test (Moretti et al, 2012). Kumar et al (2011) also reported positive effects of fluoxetine on mild and chronic unpredictable stress (Kumar et al, 2011).…”

“…The mechanism of antidepressant effects of ascorbic acid is due to the reduction of oxidative stress parameters (Moretti et al, 2012).…”