Asesorías Innovadoras en Recursos Humanos Para Las Pymes Mediante El Uso De La Red De Internet

Gooding, Clare; Roberts, G. C.; Smith, Christopher W.J.

doi:10.22458/rna.v4i1.535

RNA

1969

DOI: 10.22458/rna.v4i1.535

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Asesorías Innovadoras en Recursos Humanos Para Las Pymes Mediante El Uso De La Red De Internet

Clare Gooding

G. C. Roberts²,

Christopher W.J. Smith³

Abstract: Este estudio examina la viabilidad de la implementación de una empresa de consultoría en recursos humanos que ofrezca sus servicios por medio del aprovechamiento de las TIC que ofrece Internet. La necesidad de este tipo de servicio existe y ha quedado comprobada en Costa Rica en diversos estudios realizados por profesionales en recursos humanos, las Mipymes requieren los servicios de asesoría en recursos humanos para mejorar la gestión mediante la identificación de los problemas y la implementación de soluc… Show more

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Cited by 51 publications

References 46 publications

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Silencers regulate both constitutive and alternative splicing events in mammals

Pozzoli

Sironi

2005

CMLS, Cell. Mol. Life Sci.

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Constitutive and alternative splicing events are regulated, in higher eukaryotes, by the action of multiple weak cis-acting elements and trans-acting factors. In particular, several evidences have suggested that silencers might have a fundamental role in preventing pseudoexon inclusion in mature transcripts and in defining constitutive exons by suppressing nearby decoy splice sites. Moreover, silencer elements allow the recruitment of regulatory factors to alternatively spliced exons, therefore participating in the modulation of alternative splicing pathways. Here we focus on splicing repression mechanisms in mammals, with particular concern to both exonic and intronic silencer elements, secondary structure formation and role in human genetic disease.Recently, in addition to the availability of a growing number of sequence elements deriving from the analysis of individual regulated exons, approaches have been developed that allowed the systematic identification of splicing silencers. These methods and are briefly described, as well as the motifs they retrieved, and summary of silenced exons is provided.

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Silencers regulate both constitutive and alternative splicing events in mammals

Pozzoli

Sironi

2005

CMLS, Cell. Mol. Life Sci.

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Structure-function relationships of the polypyrimidine tract binding protein

Auweter

Allain

2007

Cell. Mol. Life Sci.

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Abstract. The polypyrimidine tract binding protein (PTB) is a 58-kDa RNA binding protein involved in multiple aspects of mRNA metabolism including splicing regulation, polyadenylation, 3'end formation, internal ribosomal entry site-mediated translation, RNA localization and stability. PTB contains four RNA recognition motifs (RRMs) separated by three linkers. In this review we summarize structural information on PTB in solution that has been gathered during the past 7 years using NMR spectroscopy and small-angle X-ray scattering. The structures of all RRMs of PTB in their free state and in complex with short pyrimidine tracts, as well as a structural model of PTB RRM2 in complex with a peptide, revealed unusual structural features that provided new insights into the mechanisms of action of PTB in the different processes of RNA metabolism and in particular splicing regulation.

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Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing

Attig

Federico

Gooding

et al. 2018

Cell

139

152

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SummaryLong mammalian introns make it challenging for the RNA processing machinery to identify exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection by recruiting dozens of RNA-binding proteins (RBPs) to introns. This includes MATR3, which promotes binding of PTBP1 to multivalent binding sites within LINEs. Both RBPs repress splicing and 3′ end processing within and around LINEs. Notably, repressive RBPs preferentially bind to evolutionarily young LINEs, which are located far from exons. These RBPs insulate the LINEs and the surrounding intronic regions from RNA processing. Upon evolutionary divergence, changes in RNA motifs within LINEs lead to gradual loss of their insulation. Hence, older LINEs are located closer to exons, are a common source of tissue-specific exons, and increasingly bind to RBPs that enhance RNA processing. Thus, LINEs are hubs for the assembly of repressive RBPs and also contribute to the evolution of new, lineage-specific transcripts in mammals.Video Abstract

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Asesorías Innovadoras en Recursos Humanos Para Las Pymes Mediante El Uso De La Red De Internet

Cited by 51 publications

References 46 publications

Silencers regulate both constitutive and alternative splicing events in mammals

Silencers regulate both constitutive and alternative splicing events in mammals

Structure-function relationships of the polypyrimidine tract binding protein

Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing

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