ASO Author Reflections: Gallbladder Cancer Research, “One for All and All for One” Strategy to Improve Research

Vega, Eduardo; Newhook, Timothy E.; Vauthey, Jean‐Nicolas

doi:10.1245/s10434-021-09628-1

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Gallbladder cancer is the 22nd most prevalent and 17th most deadly cancer worldwide [ 1 , 2 , 3 ]. It is noted to disproportionately affect females more than males, perhaps due to the higher propensity of females to have gallstone disease [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Precursor Lesions of Gallbladder Carcinoma: Disease Concept, Pathology, and Genetics

et al. 2022

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Understanding the pathogenesis and carcinogenesis of gallbladder adenocarcinoma is important. The fifth edition of the World Health Organization’s tumor classification of the digestive system indicates three types of preinvasive neoplasm of the gallbladder: pyloric gland adenoma (PGA), biliary intraepithelial neoplasia (BilIN), and intracholecystic papillary neoplasm (ICPN). New terminologies have also been introduced, such as intracholecystic papillary-tubular neoplasm, gastric pyloric, simple mucinous type, and intracholecystic tubular non-mucinous neoplasm (ICTN). Pancreatobiliary maljunction (PBM) poses a markedly high risk for bile duct carcinoma, which was analyzed and investigated mainly by Asian researchers in the past; however, recent studies have clarified a similar significance of biliary carcinogenesis in Western countries as well. In this study, we reviewed and summarized information on three gallbladder neoplastic precursors, PGA, BilIN, and ICPN, and gallbladder lesions in patients with PBM.

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