In Mexico, there are various factors that limit the development of the rural population. They highlight the poverty that limits a life free of socioeconomic deprivations; migration, which forces the search for different opportunities, and climate change that causes drought affecting crops. In rural communities of the potosino-zacatecano semi-desert there are years without rainfall, and although the peasants generate experiences to deal with the changes, the strategies have not been enough. This has caused abandonment of plots and loss of local genetic resources of agrobiodiversity. A model of complementary agriculture (AgriCom) and conservation of low technological cost, using local resources, was designed to permanently produce nopal vegetables, prickly pear, and fodder (Opuntia ficus indica), figs (Ficus carica) and corn (Zea mays). Planting, production, and harvest times differ throughout the year, and, except for maize, they have low water-management requirements. With AgriCom, the inhabitants obtain economic income deferred over time, do not depend on seasonal corn crops and are self-employed. In a year of evaluation, the Equivalent Land Use showed higher productivity and commercial volume with the complementarity of crops. The nopales were successful and the corn did not prosper due to drought.