Asociaciones de probióticos para la prevención de la enterocolitis necrosante y la reducción de la sepsis tardía y la mortalidad neonatal en recién nacidos pretérmino de menos de 1.500 g: una revisión sistemática

Baucells, Benjamin J.; Hally, Maria Mercadal; Sánchez, Airam Tenesor Álvarez; J, Figueras Aloy

doi:10.1016/j.anpedi.2015.07.038

Cited by 35 publications

(7 citation statements)

References 24 publications

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“…It has been shown that probiotics can restore intestinal micro-ecological balance, repair the intestinal membrane barrier, improve intestinal colonization, and inhibit the excessive growth of opportunistic pathogens [ 24 ]. Probiotics help to decrease NEC, late-onset sepsis, and the mortality of preterm infants [ 25 ]. It is suggested that the status, the gene phenotype, and the gut microbiota of pregnant women, as well as the delivery mode, could influence the establishment and construction of gut microbiota in newborns [ 26 – 29 ].…”

Section: Discussionmentioning

confidence: 99%

Prenatal and postnatal antibiotic exposure influences the gut microbiota of preterm infants in neonatal intensive care units

Zou

Liu

et al. 2018

Ann Clin Microbiol Antimicrob

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BackgroundTo explore the influences of prenatal antibiotic exposure, the intensity of prenatal and postnatal antibiotic exposure on gut microbiota of preterm infants and whether gut microbiota and drug resistant strains in the neonatal intensive care unit (NICU) over a defined period are related.MethodsAmong 28 preterm infants, there were two groups, the PAT (prenatal antibiotic therapy) group (12 cases), and the PAF (prenatal antibiotic free) group (12 cases). Fecal samples from both groups were collected on days 7 and 14. According to the time of prenatal and postnatal antibiotic exposure, cases were divided into two groups, H (high) group (11 cases) and L (low) group (11 cases), and fecal samples on day 14 were collected. Genomic DNA was extracted from the fecal samples and was subjected to high throughput 16S rRNA amplicon sequencing. Bioinformatics methods were used to analyze the sequencing results.ResultsPrenatal and postnatal antibiotic exposure exercised influence on the early establishment of intestinal microflora of preterm infants. Bacteroidetes decreased significantly in the PAT group (p < 0.05). The number of Bifidobacterium significantly decreased in the PAT group and H group (p < 0.05). The early gut microbiota of preterm infants with prenatal and postnatal antibiotic exposure was similar to resistant bacteria in NICU during the same period.ConclusionPrenatal and postnatal antibiotic exposure may affect the composition of early gut microbiota in preterm infants. Antibiotic-resistant bacteria in NICU may play a role in reshaping the early gut microbiota of preterm infants with prenatal and postnatal antibiotic exposure.Electronic supplementary materialThe online version of this article (10.1186/s12941-018-0264-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Prenatal and postnatal antibiotic exposure influences the gut microbiota of preterm infants in neonatal intensive care units

Zou

Liu

et al. 2018

Ann Clin Microbiol Antimicrob

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“…The latest meta-analysis had an obvious lack of effect of probiotics in ELBW infants, on the prevention of sepsis, and on the use of a specific probiotic strain. A meta-analysis by Baucells et al [72] included 9 studies pooling a total of 3,521 newborns and found that probiotics administration was associated with a reduced risk of NEC (RR 0.39; 95% CI 0.26-0.57) and mortality (RR 0.70; 95% C 0.52-0.93), with no difference to placebo regarding late-onset sepsis (RR 0.91; 95% CI 0.78-1.06).…”

Section: Discussionmentioning

confidence: 99%

The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants

Dermyshi

Wang²,

Yan³

et al. 2017

Neonatology

16,446

137

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Background: Over the last few years, probiotics have been one of the most studied interventions in neonatal medicine. Objectives: The aim of this work was to analyse all studies (randomized controlled trials, RCTs, and observational studies) assessing the use of probiotics in very low birth weight (VLBW) preterm infants. Search Methods: A systematic literature search was conducted using PubMed, Embase, Cochrane Library, and Web of Science. The data from RCTs and observational studies were pooled and analysed separately. Selection Criteria: RCTs and observational studies that enrolled VLBW infants with enteral administration of probiotics were considered. Extracted study data included probiotic characteristics and at least 1 clinical outcome (necrotizing enterocolitis [NEC], late-onset sepsis or all-cause mortality). Data Collection and Analysis: Forty-four studies were eligible for our review: 30 RCTs and 14 observational studies. Severe NEC rates (stage II or more) and all-cause mortality were reduced among the probiotic groups in both the RCTs (RR 0.57, 95% CI 0.47-0.70, and RR 0.77, 95% CI 0.65-0.92, respectively) and the observational studies (RR 0.51, 95% CI 0.37-0.70, and RR 0.71, 95% CI 0.62-0.81, respectively). Furthermore, there was a 12% reduction in the risk of sepsis in RCTs and a 19% reduction in observational studies. The meta-analysis of observational studies showed a reduction in the risk of NEC in extremely low birth weight infants. However, this was not statistically significant. Conclusions: This meta-analysis of RCT and observational studies found that the use of probiotics was beneficial for the prevention of severe NEC, late-onset sepsis, and all-cause mortality in VLBW infants.

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“…Language was not restricted. Additional strategies to identify studies included manual review of reference lists of key articles that fulfilled our eligibility criteria, use of the “related articles” feature in PubMed, use of the “cited by” tool in Web of Science and Google Scholar, and manual review of reference lists of meta-analyses on probiotics in preterm infants [ 23 , 24 , 25 , 27 , 28 , 30 , 34 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. The search method used to identify all relevant articles was discussed and developed by two authors (EV-M and EV) and the final search string was approved by all authors.…”

Section: Methodsmentioning

confidence: 99%

Probiotic Supplementation in Preterm Infants Does Not Affect the Risk of Bronchopulmonary Dysplasia: A Meta-Analysis of Randomized Controlled Trials

et al. 2017

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Probiotic supplementation reduces the risk of necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) in preterm infants, but it remains to be determined whether this reduction translates into a reduction of other complications. We conducted a systematic review and meta-analysis to evaluate the possible role of probiotics in altering the risk of bronchopulmonary dysplasia (BPD). Fifteen randomized controlled trials (4782 infants; probiotics: 2406) were included. None of the included studies assessed BPD as the primary outcome. Meta-analysis confirmed a significant reduction of NEC (risk ratio (RR) 0.52, 95% confidence interval (CI) 0.33 to 0.81, p = 0.004; random effects model), and an almost significant reduction of LOS (RR 0.82, 95% CI 0.65 to 1.03, p = 0.084). In contrast, meta-analysis could not demonstrate a significant effect of probiotics on BPD, defined either as oxygen dependency at 28 days of life (RR 1.01, 95% CI 0.91 to 1.11, p = 0.900, 6 studies) or at 36 weeks of postmenstrual age (RR 1.07, 95% CI 0.96 to 1.20, p = 0.203, 12 studies). Meta-regression did not show any significant association between the RR for NEC or LOS and the RR for BPD. In conclusion, our results suggest that NEC and LOS prevention by probiotics does not affect the risk of developing BPD in preterm infants.

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Asociaciones de probióticos para la prevención de la enterocolitis necrosante y la reducción de la sepsis tardía y la mortalidad neonatal en recién nacidos pretérmino de menos de 1.500 g: una revisión sistemática

Cited by 35 publications

References 24 publications

Prenatal and postnatal antibiotic exposure influences the gut microbiota of preterm infants in neonatal intensive care units

Prenatal and postnatal antibiotic exposure influences the gut microbiota of preterm infants in neonatal intensive care units

The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants

Probiotic Supplementation in Preterm Infants Does Not Affect the Risk of Bronchopulmonary Dysplasia: A Meta-Analysis of Randomized Controlled Trials

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