Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes

Meena, Jairam; Ojha, Rakesh; Muruganandam, A. V.; Krishnamurthy, Sairam

doi:10.1016/j.neulet.2011.07.051

Cited by 31 publications

(14 citation statements)

References 15 publications

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“…Moreover, it has been reported that the MAR possesses the highest amount of saponins and exhibits maximum inhibitory effect on acetylcholine and monoamine metabolizing enzymes in vitro. 8 AR is a popular vegetable, its usage extending over 2000 years in Europe as cited by the Roman literature. AR is used in Ayurveda for various indications and as such there are about 64 Ayurvedic formulations containing AR.…”

Section: Introductionmentioning

confidence: 99%

Asparagus racemosusmodulates the hypothalamic–pituitary–adrenal axis and brain monoaminergic systems in rats

Krishnamurthy

Garabadu

Reddy

2013

Nutritional Neuroscience

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Section: Introductionmentioning

confidence: 99%

Asparagus racemosusmodulates the hypothalamic–pituitary–adrenal axis and brain monoaminergic systems in rats

Krishnamurthy

Garabadu

Reddy

2013

Nutritional Neuroscience

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“…alkaloids, flavanoids, tannins in methanolic extract while steroids were absent [12] , whereas Nagamani et al in their study showed the absence of alkaloids, flavanoids, tannins and presence of steroids in ethanolic extract while all the phytochemical contituents were present in aqueous extract [13] which is in contrast with our study showing the presence of alkaloids, flavanoids, tannins and absence of steroids in the ethanolic extract whereas all the active phytoconstituents were present in aqueous extract. These active components usually interfere with growth and metabolism of microorganisms in a negative manner [6] . Phenolic compounds like tannins present in the cells of plants are potent inhibitors of many hydrolytic enzymes such as proteolytic macerating enzymes used by plant pathogens.…”

Section: Discussionmentioning

confidence: 99%

“…A.racemosus is widely used as antioxidant [2,3] , antitussive [4] , gastro protective [5] , neuroprotective [6] and to cure depression [7] .…”

Section: Introductionmentioning

confidence: 99%

Study of antibacterial activity and biochemical analysis of Asparagus racemosus against selected pathogens causing human intestinal disturbances.

2018

IJAPSA

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The present study is based on the investigation of antibacterial activity of aqueous and ethanolic extracts of Asparagus racemosus. The microorganisms used in the study are human intestinal disturbance causing pathogens viz Staphylococcus aureus, Proteus vulgaris and Escherichia coli. The susceptibility of bacterial strains against the two extracts was determined using disk diffusion method. The most susceptible microorganism was E.coli while the least susceptible organisms was P.vulgaris. Highest antibacterial activity was observed with ethanolic extract of Asparagus recemosus against E.coli (10mm) while minimum activity was observed with aqueous extract of Asparagus recemosus against P.vulgaris (1mm). Ethanolic extract of the sample were more effective in comparison to the aqueous extract in inhibiting the growth of pathogens under study. They were less potent when compared with ciprofloxacin used as positive control. Biochemical analysis shows the presence of alkaloid, flavanoids and tannins in both the extracts while steroids were found only in the aqueous extracts of the plant.

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“…Its medicinal use has been reported in Indian traditional medicine such as Ayurveda, Unani and Siddha. A.racemous is widely used as antioxidant 3,4 , gastro protective 5 , neuroprotective 6 . The tremendous potential of the plant in health care and trade is proven by various experimental studies; which authenticates the traditional practices of this plant extracts in curing many of the above mentioned diseases.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Phytochemical Screening, Antibacterial Activity and Gc-MS Analysis of Asparagus Racemosus Root Extract

Beldal¹,

Selvaraju²,

Londonkar³

2017

Int. Res. J. Pharm.

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Asparagus racemosus is one of the most frequently used herb in Indian traditional medicine is selected to study its medicinally active substances present in ethanol-extract. Preliminary Phytochemical screening of the extracts revealed the presence of triterpenoids, flavonoids, alkaloids, glycosides, fatty acids, phenolic compounds, saponins and tannins. The ethanol extract of the root of A. racemosus has showed the spectrum of inhibition on Staphylococcus aureus, Klebsiella pneumonia, E. coli, Enterococcus faecal, indicating that the phytocompounds present in it has promising antimicrobial activity. Further it is subjected to identify the number of constituents present in the A. racemosus by GC-MS analysis. The results obtained by the above extract have more or less similar phytoconstituents. In total there are16 compounds were identified in GC-MS analysis of ethanolic extracts of Asparagus racemous root which are medicinal important to become a potential drug in future perspective.

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Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes

Cited by 31 publications

References 15 publications

Asparagus racemosusmodulates the hypothalamic–pituitary–adrenal axis and brain monoaminergic systems in rats

Asparagus racemosusmodulates the hypothalamic–pituitary–adrenal axis and brain monoaminergic systems in rats

Study of antibacterial activity and biochemical analysis of Asparagus racemosus against selected pathogens causing human intestinal disturbances.

Preliminary Phytochemical Screening, Antibacterial Activity and Gc-MS Analysis of Asparagus Racemosus Root Extract

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