Aspectos clínicos e patológicos da intoxicação por Sida carpinifolia (Malvaceae) em caprinos no Rio Grande do Sul

Colodel, Edson Moleta; Driemeier, David; Loretti, Alexandre Paulino; Gimeno, Eduardo Juan; Traverso, Sandra Davi; Seitz, A.; Zlotowski, Priscila

doi:10.1590/s0100-736x2002000200004

Cited by 34 publications

(62 citation statements)

References 12 publications

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“…These cellular changes were similar to those reported previously in cattle, 16 goats, 7,13,19 sheep, 33 and ponies 25 poisoned by S. carpinifolia. Similar lesions were also reported in cases of poisoning by plants that contain the alkaloid swainsonine, 1,3,4,9,10,12,20,22 as well as in cases of inherited alpha-mannosidosis in cattle, 21,39 humans, 29 domestic cats, 5,27 and the guinea pig.…”

Section: Discussionsupporting

confidence: 90%

“…Occasionally, axonal spheroids were seen at the granular layer of the cerebellum and in the bulb. Such residual lesions were also reported in goats 7 and sheep 33 that presented neurologic signs and were subject to postmortem examination after long periods without consumption of S. carpinifolia. The attenuation of neurologic signs can be explained by histologic and functional cerebellar cortex uniformity.…”

Section: Discussionsupporting

confidence: 56%

“…fastigiatum; 31 Ipomea spp. I. sericophylla, 4 I. riedelli, 4 and I. carnea; 2 Turbina cordata; 10 Sida carpinifolia; 7,13,16,19,25,33 and the fungi Claviceps paspali 32 and Aspergilus clavatus. 24 S. carpinifolia, of the Malvaceae family, is a weed plant common in humid and shaded places, flourishing especially in pastures and wastelands.…”

Section: Introductionmentioning

confidence: 99%

“…24 S. carpinifolia, of the Malvaceae family, is a weed plant common in humid and shaded places, flourishing especially in pastures and wastelands. 23 This plant is responsible for producing lysosomal storage disease in goats, 7,13,19 ponies, 25 sheep, 33 and cattle. 16 The main clinical signs in goats, sheep, and cattle are incoordination with dysmetria and head tremors associated with frequent falls.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle

Furlan

Lucioli

Veronezi

et al. 2009

Veterinary Pathology

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Abstract. Clinical and pathologic findings for the spontaneous poisoning by Sida carpinifolia in cattle are described in this study. A survey on field cases of S. carpinifolia in cattle was carried out on farms of Alto Vale do Itajaí, State of Santa Catarina, southern Brazil. Sixteen affected animals were clinically evaluated and 9 were subjected to postmortem examination. The main clinical signs consisted of marching gait, alert gaze, head tremors, and poor growth. Histologic and ultrastructural lesions consisted of vacuolization and distension of neuronal perikarya, mainly from Purkinje cells, and of the cytoplasm of acinar pancreatic and thyroid follicular cells. Clinical signs and lesions varied from mild to severe. Improvement of the clinical signs was observed in cattle after a period of up to 90 days without consuming the plant; however, residual lesions, mainly characterized by axonal spheroids and absence of Purkinje neurons in some areas of the cerebellum, were observed in these cases. It is concluded that the natural chronic consumption of S. carpinifolia was the etiologic cause of storage disease in cattle in this study.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle

Furlan

Lucioli

Veronezi

et al. 2009

Veterinary Pathology

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“…Nas regiões Sul e Sudeste, esse grupo é representado por Sida carpinifolia, que causa intoxicação em caprinos, ovinos, bovinos e equinos (Driemeier et al 2000, Colodel et al 2002a, 2002b, Loretti et al 2003. Na Ilha de Marajó, a intoxicação por I. carnea subsp.…”

Section: Introductionunclassified

Biópsia hepática como método diagnóstico para intoxicação por plantas que contém swainsonina

et al. 2016

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RESUMO.-Neste trabalho objetivou-se avaliar a técnica de biópsia hepática como um teste de valor diagnóstico para intoxicações por plantas que contém swainsonina.Para isso, reproduziu-se experimentalmente a doença com as folhas secas de Ipomoea marcellia contendo 0,02% de swainsonina em caprinos. O Grupo I foi constituído por 6 caprinos que receberam a planta misturada a ração na dose de 4g/kg (0,8mg de swainsonina/kg) até a observação dos primeiros sinais clínicos neurológicos. Outros dois caprinos que não receberam a planta na dieta constituíram o grupo controle (Grupo II). Foram realizadas biópsias hepá-ticas pela técnica percutânea cega com agulha de Menghini, no dia zero e com intervalos semanais nos caprinos do experimento. As biópsias hepáticas foram fixadas em formol tamponado 10%, processadas rotineiramente, coradas pela hematoxilina-eosina e histoquímica de lectinas. Vacuolização hepatocelular similar àquelas descritas em caso de doença de depósito lisossomal foram identificadas em todos os caprinos do Grupo I no 7º dia de experimento nas amostras coradas pela hematoxilina-eosina. With the aim to investigate the use of hepatic biopsies for the diagnosis of poisoning by swainsonine-containing plants, dry leaves of Ipomoea marcellia containing 0.02% of swainsonine were administered to goats. Group I, with six goats, ingested 4g/kg of dry plant (0.8mg of swainsonina/kg) daily until the observation of the first neurologic signs. Two goats that did not receive the plant were used as control (Group II). Hepatic biopsies with the Menghini needle were performed by the percutaneous technique at day zero and at weekly intervals after the start of the administration of I. marcellia. Biopsy samples were fixed in 10% formaline, processed routinely, and stained by hematoxilin-eosin and by lectins histochemistry. Hepatocellular vacuolization similar to those described in cases of lysosomal storage disease were identified in all goats of Group I from the seven day of plant consumption in the samples satained with hematoxylin-eosin. Using lectin histochemistry, consistent labellings were observed with Concanavalia ensiformis (Con-A) e Triticum vulgaris (WGA). It is concluded that routinely histological evaluation of liver biopsies can be used in the diagnosis of poisoning by swainsonine containing plants, even in goats without clinical signs, and lectin histochemistry which can be used as supplementary diagnostic method.INDEX TERMS: Poisonous plants, lysosomal storage disease, swainsonina, plant poisoning, liver biopsy.

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Nervous System

Diplomate

Sherman

2009

Goat Medicine

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Aspectos clínicos e patológicos da intoxicação por Sida carpinifolia (Malvaceae) em caprinos no Rio Grande do Sul

Cited by 34 publications

References 12 publications

Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle

Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle

Biópsia hepática como método diagnóstico para intoxicação por plantas que contém swainsonina

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