Aspects biologiques de la leishmaniose viscérale infantile

Hassani, Moncef Amrani; Lahlou, H.; Alami, Meryem; Baba, Ahmed Filali; Youssfi, Ghizlane el; Ismaili, Laila; Chaouki, S.; Atmani, S.; Hida, M.

doi:10.1016/s1773-035x(11)70769-9

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…These results are in agreement with those found in other studies that prove L. infantum is the species responsible of VL in several foci [26, 27]. The zymodeme MON-1 is the most common [28], the second identified zymodeme is MON-24 [11].…”

Section: Discussionsupporting

confidence: 92%

New epidemiological aspects of visceral and cutaneous leishmaniasis in Taza, Morocco

et al. 2016

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BackgroundLeishmaniasis is considered among the main endemic diseases in Morocco. However, further knowledge about epidemiological aspects of this disease is needed in several provinces to plan control and preventive strategies to tackle the disease. The present study aims to determine the epidemiological aspect of cutaneous and visceral leishmaniasis in Taza Province from 2007–2014 and to identify the circulating species in this province.ResultsThe temporal study from 2007 to 2014 showed that the number of cutaneous leishmaniasis cases increased since 2010. During the period of study, most leishmaniasis cases were detected in both urban and rural areas with 34% of cases detected in two urban localities, Bab Zitouna and Bab tété with 297 and 106 cases, respectively. The molecular study of cutaneous leishmaniasis showed the presence of non-sporadic Leishmania infantum and Leishmania tropica in this province. Regarding visceral leishmaniasis, Leishmania infantum is the species that has been identified.ConclusionsThe epidemio-molecular study of leishmaniasis in Taza Province showed the coexistence of two species of Leishmania in the same foci. They also indicated that CL due to Leishmania infantum is more prevalent than reported in the literature. These results will be helpful for the implementation of control strategies by targeting dogs that constitute a reservoir of Leishmania infantum.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-016-1910-x) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 92%

New epidemiological aspects of visceral and cutaneous leishmaniasis in Taza, Morocco

et al. 2016

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Epidemiological characteristics of visceral leishmaniasis in Morocco (1990–2014): an update

Mniouil

Fellah²,

Amarir

et al. 2017

Acta Tropica

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Cost-effectiveness of diagnostic-therapeutic strategies for paediatric visceral leishmaniasis in Morocco

et al. 2017

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IntroductionVisceral leishmaniasis (VL) is a neglected parasitic disease with a high fatality rate if left untreated. Endemic in Morocco, as well as in other countries in the Mediterranean basin, VL mainly affects children living in rural areas. In Morocco, the direct observation of Leishmania parasites in bone marrow (BM) aspirates is used to diagnose VL and meglumine antimoniate (SB) is the first line of treatment. Less invasive, more efficacious and safer alternatives exist. In this study we estimate the cost-effectiveness of alternative diagnostic-therapeutic algorithms for paediatric VL in Morocco.MethodsA decision tree was used to estimate the cost-effectiveness of using BM or rapid diagnostic tests (RDTs) as diagnostic tools and/or SB or two liposomal amphotericin B (L-AmB) regimens: 6-day and 2-day courses to treat VL. Incremental cost-effectiveness ratios, expressed as cost per death averted, were estimated by comparing costs and effectiveness of the alternative algorithms. A threshold analysis evaluated at which price L-AmB became cost-effective compared with current practices.ResultsImplementing RDT and/or L-AmB treatments would be cost-effective in Morocco according to the WHO thresholds. Introducing the 6-day course L-AmB, current second-line treatment, would be highly cost-effective if L-AmB price was below US$100/phial. The 2-day L-AmB treatment, current standard treatment of paediatric VL in France, is highly cost-effective, with L-AmB at its market price (US$165/phial).ConclusionsThe results of this study should encourage the implementation of RDT and/or short-course L-AmB treatments for paediatric VL management in Morocco and other North African countries.

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Aspects biologiques de la leishmaniose viscérale infantile

Cited by 3 publications

References 17 publications

New epidemiological aspects of visceral and cutaneous leishmaniasis in Taza, Morocco

New epidemiological aspects of visceral and cutaneous leishmaniasis in Taza, Morocco

Epidemiological characteristics of visceral leishmaniasis in Morocco (1990–2014): an update

Cost-effectiveness of diagnostic-therapeutic strategies for paediatric visceral leishmaniasis in Morocco

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