1985
DOI: 10.1093/chromsci/23.6.238
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Aspects of Small-Bore Column Technology

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Cited by 15 publications
(3 citation statements)
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“…Apart from the injection volume, the major source of extra-column band broadening in LC is the dead volume of the detector flowcell [2,8]. Dispersion is reduced with low volume cells but the limit of detection is increased due to the reduced pathlength.…”
Section: Evaluation Of the Optimum Detector Flowceilmentioning
confidence: 99%
“…Apart from the injection volume, the major source of extra-column band broadening in LC is the dead volume of the detector flowcell [2,8]. Dispersion is reduced with low volume cells but the limit of detection is increased due to the reduced pathlength.…”
Section: Evaluation Of the Optimum Detector Flowceilmentioning
confidence: 99%
“…However, since the retention time at a constant linear (optimum) velocity is proportional to the column length, equation (1.9), this arbitrary fixed number of plates is made available in a shorter time for columns packed with smaller diameter particles. Although the separation time is independent of the column diameter, narrow bore columns elute peaks in a much smaller volume of mobile phase than conventional bore columns placing still greater demands on the design characteristics of the instrument [223][224][225][226][227]. For separations requiring a very large number of theoretical plates long columns are needed and small-particle diameter packed columns are unsuitable for this purpose due to limits on length established by the available operating pressure [61,221].…”
Section: Liquid Chromatographymentioning
confidence: 99%
“…An example of a two-column separation of a mixture of major deoxyribonucleosides and their 5 f -monophosphate deoxynucleotides on a strong cation exchange column and a reversed-phase column is shown in figure 8.24 [298]. The neutral deoxyribonucleosides are switched as a single peak for separation on the reversed-phase column while their phosphate-containing analogs are resolved by the ion-exchange column.…”
Section: Multidimensional Liquid Chromatographymentioning
confidence: 99%