1996
DOI: 10.1016/0040-4020(96)00334-1
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Aspects of the Algar-Flynn-Oyamada (AFO) reaction

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Cited by 58 publications
(33 citation statements)
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“…Minimum inhibitory concentration (MIC) of the newly synthesized compounds against tested bacteria was determined using macrodilution tube method as recommended by NCCLS [69]. Applying the agar plate diffusion technique [59] some of the newly synthesized compounds were screened in vitro for antimicrobial activity against representative Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis), Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa), yeast, (Candida albicans), and fungi, (Aspergillus niger). In this method a standard 5-mm diameter sterilized filter paper disc impregnated with the compound (0.3 mg/0.1 ml of dimethyl-formamide) was placed on an agar plate seeded with thetested organism.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Minimum inhibitory concentration (MIC) of the newly synthesized compounds against tested bacteria was determined using macrodilution tube method as recommended by NCCLS [69]. Applying the agar plate diffusion technique [59] some of the newly synthesized compounds were screened in vitro for antimicrobial activity against representative Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis), Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa), yeast, (Candida albicans), and fungi, (Aspergillus niger). In this method a standard 5-mm diameter sterilized filter paper disc impregnated with the compound (0.3 mg/0.1 ml of dimethyl-formamide) was placed on an agar plate seeded with thetested organism.…”
Section: Discussionmentioning
confidence: 99%
“…Chalcones are key precursors in the synthesis of various flavonoids as they can be transformed easily in flavanones by cyclization in acidic medium, in flavones or aurones by oxidative cyclization in presence of hydrogen peroxide in basic medium (the so called Algar-FlynnOyamada reaction) [59] or other oxidants [60]. However, few new methodologies for the synthesis of chalcone have been described recently [61,62].…”
Section: Introductionmentioning
confidence: 99%
“…Although there is some controversy about the mechanism of the AFO reaction [59][60][61] and the involvement or not (pathways B and C) of epoxide formation (Scheme 7), we can state that in the presence of base, cyclization of 2′-hydroxycinnamylideneacetophenones 23 with simultaneous hydroxyl-…”
Section: Aldol Condensation/cyclodehydrogenationmentioning
confidence: 99%
“…reaction (8)(9), or as an additional product during the alkaline cyclisation of 2′-hydroxychalcone dihalides along with flavones (10). Synthesis of aurones from 2′-acetoxychalcones in a two-step process has also been reported in the literature (11).…”
Section: Introductionmentioning
confidence: 99%