Aspects of the Autoregulation of Cerebral Blood Flow

Häggendal, E.; Nilsson, Nils J.; Norbäck, B

doi:10.1097/00004311-196900720-00010

Cited by 13 publications

(8 citation statements)

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“…These results indicate that the blood flow through the retina is not reduced by a moderate reduction in perfusion pressure. Quantitative measurements of retinal blood flow at high IOP indicate that there may even be a rise in blood flow (Alm and Bill 1972). In the brain the blood flow is largely independent of the perfusion pressure at levels above 45-60 cm H,O (see Haggendal, Nilsson and Norback 1969). In the experiments reported here the true perfusion pressure is somewhat overestimated as mentioned above.…”

Section: Effects O F Changes In Iop or Wap On Pbto2supporting

confidence: 49%

“…The correlation that has been found between perfusion pressure and blood flow and the rather poor sensitivity to CO, is surprising for a vascular bed involved in the nutrition of nervous tissue. In the brain the blood flow is strongly influenced by changes in Paco2 and the flow is very efficiently autoregulated, that 26 1 is the flow remains constant within a wide range of perfusion pressures (for a recent review of the regulation of cerebral blood flow see Haggendal, Nilsson and Norback 1969).…”

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confidence: 99%

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The Oxygen Supply to the Retina, I. Effects of Changes in Intraocular and Arterial Blood Pressures, and in Arterial P_O2 and P_co2 on the Oxygen Tension in the Vitreous Body of the Cat

Alm

Bill

1972

Acta Physiologica Scandinavica

123

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ALM, A. and A. BILL. The oxygen suppb to the retina, I. Effects of changes in intraocular and arterial blood pressures, and in arterial PO, and PCO, on the oxygen tension in the vitreous body of the cat, Acta physiol. scand. 1972. 84. 261-274. The Poz in the vitreous body close to the retina, PVroz, was determined continuously with an 0, electrode. In cats with a mean arterial blood pressure of 176 & 7 cm H,O, a PaoZ of 98 5 2 mm Hg, a Pacoz of 27.0k1.2 mm H g and a p H of 7.4350.16 units the mean Pvroz was 18.931.5 mm Hg. Stepwise increments in the eye pressure had no effect on Pvroz at perfusion pressures above 50-100 cm H,O. At lower perfusion pressures Pvroz decreased. Changes in perfusion pressure caused by hemorrhage and retransfusion gave similar results. At iow Pamz levels Pvroz decreased; at high P a~o z levels values of 40-60 mm Hg were observed. Reductions in Pam decreased PvroL, increments gave either no change or a rise in Pvroz. Hypercapnia combined with high Pa0, in several cases resulted in Pvroz values between 100 and 150 mm Hg. The results indicate that the blood flow through the retina is very efficiently autoregulated, that oxygen tends to induce vasoconstriction in the retinal blood vessels, that hypocapnia gives vasoconstriction and hypercapnia marked vasodilatation.

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Section: Effects O F Changes In Iop or Wap On Pbto2supporting

confidence: 49%

mentioning

confidence: 99%

The Oxygen Supply to the Retina, I. Effects of Changes in Intraocular and Arterial Blood Pressures, and in Arterial P_O2 and P_co2 on the Oxygen Tension in the Vitreous Body of the Cat

Alm

Bill

1972

Acta Physiologica Scandinavica

123

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“…Autoregulation of blood fl ow is described as the intrinsic capacity of an organ to maintain its blood fl ow despite changes in local vascular parameters (Haggendal et al 1969). Within the eye, autoregulation is defi ned as local vascular constriction or dilation causing vascular resistance to reciprocally increase or decrease, thereby maintaining a constant nutrient supply in response to perfusion pressure changes (Harris et al 1998).…”

Section: Blood Fl Ow Autoregulation In Glaucomamentioning

confidence: 99%

Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?

Moore

Harris²,

WuDunn³

et al. 2008

OPTH

100

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Primary open angle glaucoma (OAG) is a multifactorial optic neuropathy characterized by progressive retinal ganglion cell death and associated visual fi eld loss. OAG is an emerging disease with increasing costs and negative outcomes, yet its fundamental pathophysiology remains largely undetermined. A major treatable risk factor for glaucoma is elevated intraocular pressure (IOP). Despite the medical lowering of IOP, however, some glaucoma patients continue to experience disease progression and subsequent irreversible vision loss. The scientifi c community continues to accrue evidence suggesting that alterations in ocular blood fl ow play a prominent role in OAG disease processes. This article develops the thesis that dysfunctional regulation of ocular blood fl ow may contribute to glaucomatous optic neuropathy. Evidence suggests that impaired vascular autoregulation renders the optic nerve head susceptible to decreases in ocular perfusion pressure, increases in IOP, and/or increased local metabolic demands. Ischemic damage, which likely contributes to further impairment in autoregulation, results in changes to the optic nerve head consistent with glaucoma. Included in this review are discussions of conditions thought to contribute to vascular regulatory dysfunction in OAG, including atherosclerosis, vasospasm, and endothelial dysfunction.

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“…Recently, perfusion instability, rather than a progressive decline in ocular blood flow, has been suggested to contribute to OAG. The capacity of an organ to maintain a constant blood flow or nutrient supply in response to local vascular parameter changes rely on its autoregulation [25]. Failure of stable blood flow regulation may lead to ischemic damage of the optic nerve or retinal ganglion cells.…”

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confidence: 99%

Systemic C-Reactive Protein Levels in Normal-Tension Glaucoma and Primary Open-Angle Glaucoma

Su¹,

Cheng²

2011

Glaucoma - Current Clinical and Research Aspects

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Aspects of the Autoregulation of Cerebral Blood Flow

Cited by 13 publications

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The Oxygen Supply to the Retina, I. Effects of Changes in Intraocular and Arterial Blood Pressures, and in Arterial P_O2 and P_co2 on the Oxygen Tension in the Vitreous Body of the Cat

The Oxygen Supply to the Retina, I. Effects of Changes in Intraocular and Arterial Blood Pressures, and in Arterial P_O2 and P_co2 on the Oxygen Tension in the Vitreous Body of the Cat

Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?

Systemic C-Reactive Protein Levels in Normal-Tension Glaucoma and Primary Open-Angle Glaucoma

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Aspects of the Autoregulation of Cerebral Blood Flow

Cited by 13 publications

References 0 publications

The Oxygen Supply to the Retina, I. Effects of Changes in Intraocular and Arterial Blood Pressures, and in Arterial PO2 and Pco2 on the Oxygen Tension in the Vitreous Body of the Cat

The Oxygen Supply to the Retina, I. Effects of Changes in Intraocular and Arterial Blood Pressures, and in Arterial PO2 and Pco2 on the Oxygen Tension in the Vitreous Body of the Cat

Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?

Systemic C-Reactive Protein Levels in Normal-Tension Glaucoma and Primary Open-Angle Glaucoma

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Product

Resources

About

The Oxygen Supply to the Retina, I. Effects of Changes in Intraocular and Arterial Blood Pressures, and in Arterial P_O2 and P_co2 on the Oxygen Tension in the Vitreous Body of the Cat

The Oxygen Supply to the Retina, I. Effects of Changes in Intraocular and Arterial Blood Pressures, and in Arterial P_O2 and P_co2 on the Oxygen Tension in the Vitreous Body of the Cat