EGIL HAQGENDAL, NILS JOHAN NILSSON and BENGT NORBACK. On the components of KrS5 clearance curves from the brain of the dog. Acta physiol.Scand. 1965. 66. Suppl. 258. 5-25. -Clearance curves from the brain in dogs were studied after short intra-arterial injections of Krs5. Multiexponential curves consisting of two main components were received both by recording y-and ,%radiation. The slopes of these two components corresponded to each other in the two types of curves. Local micro-injections of Krs5 in the cortical grey matter resulted in mono-exponential clearance curves with the same slope as the fast phase of the composite y-or /3-curve, whereas curves from micro-injections in the subcortical white matter had a slope corresponding to the slow phase of the composite curves. A third very slow phase of the composite y-curve was identified as due to flow in extracerebral tissue. In addition, an initial rapid phase was recorded in most curves after intraarterial injections and was assumed to be due to activity in the arterial blood. This phase 'was not present in clearance curves from blood drawn from the superior sagittal sinus, whereas the two main components representing blood flow in grey and white matter were identified. Some difficulties in the analysis of the composite clearance curves, especially concerning the slow component, are discussed.

Two groups of patients admitted with a first attack of acute pancreatitis are reviewed. The first group, consisting of 105 patients, was admitted between 1968 and 1969; the second group of 204 patients was admitted between 1974 and 1975. These groups were compared with one of 454 patients admitted between 1956 and 1960 whose details were published earlier by our unit (Edlund et al., 1968). The aim of this study was to determine whether the incidence of factors associated with pancreatitis within the population of the city of Göteborg had changed in the 20-year period. In the 1956--60 group gallstone disease was the main associated factor (68 per cent), but in the later groups alcohol-induced pancreatitis assumed the leading role (68 and 66 per cent respectively). Alcohol-induced pancreatitis tended to occur at a younger age than gallstone pancreatitis. Thirty-one per cent of 449 patients admitted with an acute attack of alcoholic pancreatitis in the two last periods of study had had previous attacks.

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