Aspergillosis in Chronic Granulomatous Disease

King, J. D.; Henriet, Stefanie; Warris, Adilia

doi:10.3390/jof2020015

Cited by 59 publications

(54 citation statements)

References 98 publications

(186 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…If CGD is suspected, it is is important to acknowledge that pneumonia may be caused by unexpected bacteria, such as Staphylococcus aureus , Aspergillus species, Burkholderia cepacia complex and enteric Gram‐negative bacteria. Pneumonia linked to the Aspergillus is the most common cause of death in children with CGD, and early recognition is vital . It is important to bear these possible microbes in mind when selecting empiric antibiotic treatment.…”

Section: Resultsmentioning

confidence: 99%

An overview of how on‐call consultant paediatricians can recognise and manage severe primary immunodeficiencies

et al. 2019

View full text Add to dashboard Cite

Severe primary paediatric immunodeficiency syndromes are rare and potentially fatal unless suspected, diagnosed and treated early. We provide clinical guidance and support for on‐call consultant paediatricians working in secondary level hospitals on how to recognise and manage children with these conditions. Our paper addresses four conditions that risk the most severe outcomes if they are not adequately cared for during on‐call periods, such as weekends: severe combined immunodeficiency, haemophagocytic lymphohistiocytosis, severe congenital neutropaenia and chronic granulomatous disease. Conclusion On‐call paediatricians are provided with advice on handling the most severe primary immunodeficiencies.

show abstract

Section: Resultsmentioning

confidence: 99%

An overview of how on‐call consultant paediatricians can recognise and manage severe primary immunodeficiencies

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Aspergillus species appear widely in our environment, most ubiquitously in soil, water and decaying plant matter [26]. There are more than 250 species, which were identi ed as the Aspergillus species, and infections caused by Aspergillus species are the primary cause of fatality in patients with chronic granulomatous disease [27,28]. Moreover, there is the most dread of mortality (about 85%-100%) in compromised patients with central nervous system aspergillosis [29].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic biomarkers for invasive aspergillosis utilizing weighted gene co-expression network analysis

Deng¹,

Ma²,

Liang³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Invasive aspergillosis (IA) has a significant mortality in immunocompromised patients. In recent years, with more aggressive immunosuppressed therapies, the incidence of IA was increasing. However, diagnostic biomarkers with high sensitivity and specificity remain rare. To get new diagnostic biomarkers, microarray dataset GSE78000 was analyzed. Methods: Weighted gene co-expression network analysis (WGCNA) was used to identify hub genes. Roc curves were employed for investigating diagnostic biomarkers for IA.Results: Hub genes were TLR4, TP53I3/PIG3, TMTC1, ITGAM, CYSTM1, FAR1, GAS7 and MKNK1. However, after we compared gene expression of hematological patients suffering from IA with non-IA patients, only TLR4, TP53I3/PIG3 and TMTC1 were significantly high expression in IA patients. At the optimal cut‐off value, TLR4 can diagnose patients with IA with 78.3% sensitivity and 72.7% specificity. TP53I3/PIG3 can diagnose patients with IA with 91.3% sensitivity and 54.5% specificity. TMTC1 can diagnose patients with IA with 78.3% sensitivity and 81.8% specificity. In addition, the data of hematological patients suffering from Staphylococcus aureus (S. aureus) and Escherichia coli (E.coli) infections were also analyzed. The results showed that TLR4 and TP53I3/PIG3 were also significantly high expression in S. aureus and E.coli infections, while only TP53I3/PIG3 was obviously higher expression in patients with bacterial infections compared with IA. As for TMTC1, we cannot annotate the gene from the microarray data. Conclusions: our results suggested that TLR4, TP53I3/PIG3 and TMTC1 might be used for the diagnosis of IA, and TP53I3/PIG3 can also be used to discriminate hematological aspergillosis and bacterial infections.

show abstract

“…y Aspergillus spp. 1,3,8 Otros gérmenes involucrados incluyen Klebsiella pneumoniae, enterobacterias, Candida spp., Salmonella spp. y Mycobacterium spp.…”

Section: Discussionunclassified

Enfermedad granulomatosa crónica: infecciones múltiples como forma de presentación. Caso clínico pediátrico

Maydana

Cabanillas

Regairaz

et al. 2018

Arch Argent Pediatr

View full text Add to dashboard Cite

Presentación de casos clínicos RESUMEN La enfermedad granulomatosa crónica es una inmunodeficiencia primaria infrecuente, debida a un defecto en la actividad microbicida de los fagocitos, originada por mutaciones en los genes que codifican alguna de las subunidades del complejo enzimático nicotinamida adenina dinucleótido fosfato oxidasa. La incidencia estimada es 1 en 250 000 recién nacidos vivos. Puede presentarse desde la infancia hasta la adultez, por lo general, en menores de 2 años. Las infecciones bacterianas y fúngicas, en conjunto con las lesiones granulomatosas, son las manifestaciones más habituales de la enfermedad. Los microorganismos aislados más frecuentemente son Aspergillus spp., Staphylococcus aureus, Serratia marcescens, Nocardia spp. Se reporta el caso clínico de un varón de 1 año de vida en el que se diagnosticó enfermedad granulomatosa crónica a partir de infecciones múltiples que ocurrieron simultáneamente: aspergilosis pulmonar invasiva, osteomielitis por Serratia marcescens y granuloma cervical por Enterobacter cloacae.

show abstract

Aspergillosis in Chronic Granulomatous Disease

Cited by 59 publications

References 98 publications

An overview of how on‐call consultant paediatricians can recognise and manage severe primary immunodeficiencies

An overview of how on‐call consultant paediatricians can recognise and manage severe primary immunodeficiencies

Diagnostic biomarkers for invasive aspergillosis utilizing weighted gene co-expression network analysis

Enfermedad granulomatosa crónica: infecciones múltiples como forma de presentación. Caso clínico pediátrico

Contact Info

Product

Resources

About