2014
DOI: 10.1016/j.exer.2014.07.025
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Aspergillus fumigatus triggers innate immune response via NOD1 signaling in human corneal epithelial cells

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Cited by 38 publications
(27 citation statements)
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“…Human corneal epithelial cells exposed to Aspergillus fumigatus can trigger innate immune response via activating NOD 1 receptors on human corneal epithelial cells, leading to the secretion of IL-6, IL-8, and tumor necrosis factor-α (TNF-α). NOD1 knockdown attenuated Aspergillus fumigatus triggered expression of IL-6 , IL-8 , and TNF-α [4]. …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Human corneal epithelial cells exposed to Aspergillus fumigatus can trigger innate immune response via activating NOD 1 receptors on human corneal epithelial cells, leading to the secretion of IL-6, IL-8, and tumor necrosis factor-α (TNF-α). NOD1 knockdown attenuated Aspergillus fumigatus triggered expression of IL-6 , IL-8 , and TNF-α [4]. …”
Section: Discussionmentioning
confidence: 99%
“…Pattern-recognition receptors are expressed by a variety of cells to identify microbial pathogens known as pathogen-associated molecular patterns (PAMPs) and to recognize cell components that are released during cell damage or death known as damage-associated molecular patterns (DAMPs). The main families of PPRs, Toll like receptors (TLRs) and nucleotide-binding oligomerization domain-containing protein (NOD)-like receptors (NLRs), have been shown to be expressed on certain epithelial cells [4]. Airway epithelial cells express a variety TLRs that help them to sense bacterial, fungal, or viral exposure and respond accordingly by secreting a large array of molecules that initiate adaptive immune response [5].…”
Section: Introductionmentioning
confidence: 99%
“…fumigatus in vitro. 31,38 The cathelicidin CRAMP also was reported to be upregulated in a murine model of Candida keratitis. 39 We have shown that several β-defensins and CRAMP are elevated in a murine model of Fusarium keratitis, 15 but there have been no comprehensive studies investigating the complement of AMP expression in HCEC in response to F. solani .…”
Section: Discussionmentioning
confidence: 99%
“…Host innate immunity is essential for the control of A. fumigatus. Many studies regarding the immune response to A. fumigatus in human beings and mice have been conducted (18)(19)(20), but the immune responses of chickens infected with A. fumigatus have not been fully explored. Multiple pattern recognition receptors (PRRs) are involved in recognizing A. fumigatus, especially Toll-like receptors (TLR), and C-type lectin receptors (CLR).…”
Section: Introductionmentioning
confidence: 99%