Aspergillus ochraceus: Metabolites, Bioactivities, Biosynthesis, and Biotechnological Potential

Abstract

Fungus continues to attract great attention as a promising pool of biometabolites. Aspergillus ochraceus Wilh (Aspergillaceae) has established its capacity to biosynthesize a myriad of metabolites belonging to different chemical classes, such as isocoumarins, pyrazines, sterols, indole alkaloids, diketopiperazines, polyketides, peptides, quinones, polyketides, and sesquiterpenoids, revealing various bioactivities that are antimicrobial, cytotoxic, antiviral, anti-inflammatory, insecticidal, and neuroprotective. Additionally, A. ochraceus produces a variety of enzymes that could have variable industrial and biotechnological applications. From 1965 until June 2022, 165 metabolites were reported from A. ochraceus isolated from different sources. In this review, the formerly separated metabolites from A. ochraceus, including their bioactivities and biosynthesis, in addition, the industrial and biotechnological potential of A. ochraceus are highlighted.

Multigene phylogeny, bioactive properties, enzymatic and dye decolorization potential of selected marine fungi from brown algae and sponges of Mauritius

“…These enzymes have important biotechnological applications in the food and beverages, textile, detergent, paper and pulp, pharmaceutical and medical industries [ 61 ]. Aspergillus ochraceus produces a variety of enzymes which have biotechnological and industrial values as reported by Hareeri et al [ 62 ]. Isolate F25 was no different and produced the seven enzymes included in our study.…”

Antimicrobial and Cytotoxic Activity of Endophytic Fungi from Lagopsis supina

“…A. ochraceus is widely distributed in soils and various agricultural commodities and is also known as a food pathogen [ 30 ]. However, this fungus can synthesize diverse beneficial metabolites, including polyketides, alkaloids, steroids, peptides, and quinones, with promising bioactivities [ 31 ]. For example, three asperochrins with significant antibacterial activity against aquatic pathogenic bacteria were obtained from the marine mangrove-derived fungus A. ochraceus [ 32 ].…”

Antimicrobial Activity of Depsidones and Macrocyclic Peptides Isolated from Marine Sponge‐Derived Fungus Aspergillus nidulans M256

“…Some of its species also have potential applications in biotechnology and industry. [4][5][6][7][8] Notably, A. nidulans is recognized for its rich reservoir of bioactive metabolites, which exhibit a wide array of biological properties such as antioxidants, antibacterial, antiviral, plant growth promotion, cytotoxicity, anti-inflammatory, and antimicrobial. [8,9] In our program to discover antimicrobial agents from marinederived fungi, the ethyl acetate extract (EtOAc) of sponge derived-fungus Aspergillus nidulans M256 exhibited antimicrobial activity (MICs: 128-256 μg/mL) against five-microorganism strains including Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus, Bacillus cereus), Gram-negative bacteria (Salmonella enterica), and yeast (Candida albicans).…”

“…Among these, the Aspergillus genus stands out as a prolific producer of diverse metabolites with numerous biological activities. Some of its species also have potential applications in biotechnology and industry [4–8] . Notably, A. nidulans is recognized for its rich reservoir of bioactive metabolites, which exhibit a wide array of biological properties such as antioxidants, antibacterial, antiviral, plant growth promotion, cytotoxicity, anti‐inflammatory, and antimicrobial [8,9] .…”