Aspergillus wound infection in an immune-competent patient – A case report

Quint, Elchanan; Kukeev, Ivan; Glinter, Hannah; Osyntsov, Anton; Barsky, Guy; Vakhrushev, Alex; Brotfain, Evgeni; Grupel, Daniel

doi:10.1016/j.clinpr.2022.100146

Cited by 3 publications

(1 citation statement)

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“…Abdominal SSI caused by A. welwitschiae has not been previously reported, partly because A. welwitschiae might have previously been misidenti ed as A. niger based only on microscopic ndings. A similar case of abdominal SSI caused by A. niger was documented and identi ed using matrix-assisted laser desorption ionization time-of-ight mass spectrometry (MALDI-TOF MS) [5]. The Aspergillus section Nigri has been reported to be indistinguishable microscopically and not completely distinguishable even by MALDI-TOF MS [6].…”

Section: Discussionmentioning

confidence: 99%

Superficial abdominal surgical site infection caused by Aspergillus welwitschiae: a case report

Horiuchi,

Watanabe,

Yaguchi

et al. 2024

Preprint

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Background Aspergillus spp. are rare causes of surgical site infections (SSIs). Aspergillus section Nigri, commonly identified as Aspergillus niger through morphological findings, has been sparsely reported as a cause of abdominal SSIs. Case presentation An 86-year-old woman with a history of hypertension, chronic kidney disease, and atrial fibrillation who was taking 6 mg of prednisolone daily for rheumatoid arthritis was admitted to our hospital because of sudden abdominal pain. An open Hartmann operation was performed on the day of admission with a diagnosis of sigmoid colon perforation. A superficial abdominal SSI was observed. Aspergillus welwitschiae, which belongs to Aspergillus section Nigri, was identified through calmodulin gene analysis. The minimum inhibitory concentration (MIC) of voriconazole (VRCZ) was 2 mg/L. Surgical removal of the infected tissue and administration of VRCZ were effective in treating the infection. Conclusions Given the reported tolerance of azoles in Nigri section species, identification and drug susceptibility testing of these fungi are highly important.

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Section: Discussionmentioning

confidence: 99%