Aspiration smear pattern as a predictor of biological behaviour in breast carcinoma

Dash, Ashok Kumar; Mohanty, Ripunjaya; Mallik, Rabi Narayan; Dash, Kedarnath

doi:10.4103/0970-9371.238633

Cited by 4 publications

(2 citation statements)

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“…From FNAC samples, clinically relevant information like estrogen and progesterone receptors, proliferative fraction and oncogenes products can be obtained in addition. It also gives information on cytological nuclear grade that is obtained easily and reproducibly (21). Tumor grading on FNAC does not require any special procedure and hence, there is no additional cost.…”

Section: Resultsmentioning

confidence: 99%

“…This unpredic tability in the study of other authors may be due to several factors such as assessment in air dried material, different staining techniques, etc. The lack of correspondence (%) may be because of different degrees of atypia in the same studied tumor, and also in few cases the Robinson score was on the higher side of grade I, which could have easily overlapped grade II because of the subjective nature of Robinson grading system (21).…”

Section: Resultsmentioning

confidence: 99%

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Correlation of Robinson’s Cytological Grading with Elston and Ellis’ Nottingham Modification of Bloom Richardson Score of Histopathology for Breast Carcinoma

AKAD,

SOCOLOV,

COVALI

et al. 2023

Maedica

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Introduction: Invasive carcinoma of the breast is one of the leading causes of death in women. In developing countries, fine needle aspiration cytology (FNAC) of the breast is used for preoperative diagnosis of breast cancer due to low cost. The grading system of breast carcinoma on FNAC is widely accepted. In the era of neoadjuvant therapy, if grading of breast carcinoma is incorporated in FNAC reports for prognostication, it will be of great help especially in patients with locally advanced disease, older patients with accompanying chronic disease and patients who reject surgery. Hence, there is much to be gained by grading a tumor on FNAC. Materials and methods:The present study was conducted on 40 cases of cytologically diagnosed breast carcinomas. Fine needle aspiration cytology smears were graded by Robinson cytological grading system. All surgical specimens were processed and the histological grading of the resulting slides was done by the Nottingham modification of Bloom Richardson score. Then, the cytological grade was compared with the histological grade and statistical analysis was done.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Correlation of Robinson’s Cytological Grading with Elston and Ellis’ Nottingham Modification of Bloom Richardson Score of Histopathology for Breast Carcinoma

AKAD,

SOCOLOV,

COVALI

et al. 2023

Maedica

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Cytohistological correlation of grading in breast carcinoma

Lingegowda

Muddegowda

Ramakantha

et al. 2011

Diagnostic Cytopathology

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Assigning a tumor grade to breast cancer provides important prognostic information and guides optimal therapy. The present study was undertaken to grade breast carcinoma on aspirates by Robinson grading (RGS) and Scarff-Bloom-Richardson grading system (SBR). Histological grading was done according to Nottingham modification of Scarff-Bloom-Richardson method and the two cytological grading systems were compared. Fifty cases of breast carcinoma with preoperative cytologic diagnosis were assigned tumor grade. Histologic grading was done on corresponding mastectomy or partially resected specimens. Statistical analysis was performed; correlation between cytologic and histologic grading was established using Spearman correlation coefficient. Regression analysis was done to assess the significance of each cytological feature. Univariate analysis showed strong correlation (P < 0.01) for all features except dissociation. Multiple regression analysis of cytologic features revealed cell dissociation nucleoli and nuclear margin as the most influential features. A concordance of 72.5% between RGS (cyto) and SBR (cyto), 64% for RGS (cyto) and SBR (histo), 82% for SBR (cyto) and SBR (histo) was noted. There was a significant association (P < 0.001) between the grades assigned to cytologic and histologic specimens. Cytologic grade could be used to predict histologic grade as significant relationship exists between grades assigned to cytologic and histologic specimens.

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Cytological Grading of Ductal Carcinoma of Breast in Fine Needle Aspirates and Its Correlation With Histological Grading

K¹,

Nilavu²

2017

jemds

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BACKGROUNDGrading of fine needle aspirates of breast carcinoma is useful for selection of appropriate therapy, especially for planning neoadjuvant chemotherapy.The aim of this study is to evaluate the cytological grading by Robinson method in FNAC samples and to correlate it with the well-known prognostic factor. Histological grading system proposed by Nottingham Modification of Bloom-Richardson. The cytologic grading system was also correlated with the axillary lymph node status. MATERIALS AND METHODSThis descriptive study was done on fifty female patients with breast lump in Department of Pathology in Coimbatore Medical College. Cytological samples were stained using H and E stain and Papanicolaou stain. Cytologic grading was done by Robinson method and compared with Nottingham modification of Scarff-Bloom-Richardson method histologic grading system. RESULTS Most of the tumours were Grade 2 tumours (46%).The concordance between cytological grade and histological grade was 86%, nearly 43 out of 50 cases. The remaining 7 cases (14%) showed discrepancy. Among these cases, five were upgraded and two were downgraded. The association between cytological grade and histological grade were statistically significant (p < 0.05). The Lymph node positivity was noted among 37.5%, 52.17% and 72.7% of Grade 1, 2 and 3 tumours respectively. High grade tumours show increased nodal positivity. The association between cytological grade and lymph node status was not statistically significant (p > 0.05). Most of the tumours were T2 (2 -5 cm). The association between tumour size and cytologic grade was not statistically significant (p > 0.05). Most of the tumours were located in outer quadrant 50%, higher grade tumours in central quadrant. CONCLUSIONThis concludes that cytological grading should be included in all FNAC reports of ductal carcinoma of breast, so that appropriate decision can be made regarding the neoadjuvant chemotherapy can be taken and overtreatment of low-grade carcinomas can be avoided. Fine needle aspiration cytology is being increasingly used to determine the benign and malignant nature of the lesion. 2 Attempts have been made to determine various prognostic parameters on FNA material to determine the best therapy. 3 KEYWORDS

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Aspiration smear pattern as a predictor of biological behaviour in breast carcinoma

Cited by 4 publications

References 0 publications

Correlation of Robinson’s Cytological Grading with Elston and Ellis’ Nottingham Modification of Bloom Richardson Score of Histopathology for Breast Carcinoma

Correlation of Robinson’s Cytological Grading with Elston and Ellis’ Nottingham Modification of Bloom Richardson Score of Histopathology for Breast Carcinoma

Cytohistological correlation of grading in breast carcinoma

Cytological Grading of Ductal Carcinoma of Breast in Fine Needle Aspirates and Its Correlation With Histological Grading

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