Aspirin degradation in surface-charged TEMPO-oxidized mesoporous crystalline nanocellulose

Carlsson, Daniel; Hua, Kai; Forsgren, Johan; Mihranyan, Albert

doi:10.1016/j.ijpharm.2013.11.032

Cited by 36 publications

(21 citation statements)

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“…This view may however not be consistent with later reports (Kocherbitov et al, 2008;Lepore et al, 2012) on the state of water sorbed to cellulose. Finally, it is also recently reported that the modification of the surface of cellulose may affect the stability of solid ASA (Carlsson et al, 2014).…”

Section: Introductionmentioning

confidence: 93%

The crystallinity of cellulose controls the physical distribution of sorbed water and the capacity to present water for chemical degradation of a solid drug

Höckerfelt

Alderborn

2014

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 93%

The crystallinity of cellulose controls the physical distribution of sorbed water and the capacity to present water for chemical degradation of a solid drug

Höckerfelt

Alderborn

2014

International Journal of Pharmaceutics

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“…A nickel-doped PbO 2 electrode (1 wt.% Nickel) was shown to substantially enhance the electrochemical degradation of aspirin in aqueous solutions due to an increase in the utilization rate of the hydroxyl group and lower energy requirements [8]. Carlsson et al introduced negative surface charges onto cellulose nanofibrils and showed that the aspirin degradation rate had increased significantly by electrochemical degradation [9]. The application of titanium dioxide (TiO 2 ) in the photocatalytic oxidation of organic compounds has been extensively studied in recent years.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Acetyl Salicylic Acid (Aspirin) Degradation under Solar Light in Presence of a TiO2-Polymeric Film Photocatalyst

2016

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Application of titanium dioxide (TiO 2 ) as a photocatalyst has presented a promising avenue for the safe photocatalytic degradation of pollutants. Increasing levels of the release of pharmaceuticals in the environment and formation of the intermediates during their degradation may impose health and environmental risks and therefore require more attention. Photocatalytic degradation of acetylsalicylic acid (aspirin) was carried out in the presence of the TiO 2 -filled polymeric film as a photocatalyst under solar light irradiation. The polymeric film incorporates TiO 2 in the matrix, which acts as a photocatalyst under solar illumination and degrades the acetyl salicylic acid (ASA) into a range of organic compounds before complete demineralization (formation of carbon dioxide and water as final products). Among the intermediates, acetic acid was found to be present in a larger amount compared to other organic acids. The qualitative/quantitative analyses of the intermediates resulted in the determination of the most probable reaction's mechanism in the degradation process. The mechanism of degradation of acetylsalicylic acid and its reaction pathway were developed from liquid chromatography/mass spectroscopy (LC/MS), Fourier Transform Infra Red (FTIR) and UV spectrophotometric analysis. It was found that hydroxyl groups were dominant in the degradation process compared to electrons and holes generated by TiO 2 . The total organic carbon (TOC) analysis was also carried out to analyze the organic carbon content of the intermediates formed during the course of degradation.

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“…The NFCs obtained by TEMPO-mediated oxidation show properties of high crystallinity, mostly uniform widths (3-4 nm), and large aspect ratios (>100). Moreover, the presence of negatively charged sodium carboxylate groups on the surface of the CNFs makes it possible to completely disperse them at the individual nanofibril level in water by electrostatic repulsion and/or osmotic effects (Carlsson et al 2014). The carboxylate content on the surface of NFC can be tailored by various amounts of NaClO as the primary oxidant (Liu et al 2016b).…”

Section: Introductionmentioning

confidence: 99%

“…Figure 4.1 shows the chemical mechanism of cellulose surface modification during TEMPO-mediated oxidation, where also the intermediate oxidation product, aldehyde groups, is shown. The oxidation is selective to the primary O(6) hydroxyls on the surface of cellulose nanofibrils, and, if conducted under controlled conditions, does not result in dissolution of cellulose or morphological and structural changes(Carlsson et al 2014;Saito and Isogai 2004).…”

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confidence: 99%

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Nanocellulose from the Appalachian Hardwood Forest and Its Potential Applications

Hassanzadeh¹

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Nanofibrillated cellulose (NFCs) are nanoscale fibers of high aspect ratio that can be isolated from a wide variety of cellulosic sources, including wood and bacterial cellulose. With high strength despite of their low density, NFCs are a promising renewable building block for the preparation of nanostructured materials and composites. To fabricate NFC-based materials with improved mechanical and chemical properties and additional new functionalities for different applications, it is essential to tailor the surface properties of individual NFCs. The surface structures control the interactions between NFCs and ultimately dictate the structure and macroscale properties of the bulk material. This research was focused on determining the feasibility of using hardwood residues from the Appalachian Hardwood Forest for the production of nanofibrillated cellulose (NFC). In addition, some modifications during the NFC production process were performed to evaluate their improvement to incorporate more antimicrobial copper in the cellulosic backbone. This thesis has been divided in the following main chapters: 1) Literature review regarding to nanocellulosic materials and their production processes, 2) Nanocellulose current and potential applications, 3) Nanofibrillated cellulose from the Appalachian Hardwood logging residues, 4) Modified nanofibrillated from the Appalachian Hardwood logging residues, 5) Preparation of nanocellulose using ionic liquids-A review, 6) Nanocellulose-based drug delivery system-A review, 7) Safety aspects on the utilization of lignocellulosic based materials-A review.

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Aspirin degradation in surface-charged TEMPO-oxidized mesoporous crystalline nanocellulose

Cited by 36 publications

References 34 publications

The crystallinity of cellulose controls the physical distribution of sorbed water and the capacity to present water for chemical degradation of a solid drug

The crystallinity of cellulose controls the physical distribution of sorbed water and the capacity to present water for chemical degradation of a solid drug

Mechanism of Acetyl Salicylic Acid (Aspirin) Degradation under Solar Light in Presence of a TiO2-Polymeric Film Photocatalyst

Nanocellulose from the Appalachian Hardwood Forest and Its Potential Applications

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