Aspirin inhibits androgen response to chorionic gonadotropin in humans

Abstract

Eicosanoids play an important role in the regulation of the hypothalamic-pituitary axis; less clear is their role in testicular steroidogenesis. To evaluate the involvement of cyclooxygenase metabolites, such as prostaglandins, in the regulation of human testicular steroidogenesis, we examined the effects of a prostaglandin-blocker, aspirin, on plasma testosterone, pregnenolone, progesterone, 17OH-progesterone, androstenedione, dehydroepiandrosterone, and 17beta-estradiol response to human chorionic gonadotropin (hCG) in normal male volunteers in a placebo-controlled, single-blinded study. To test the efficacy of aspirin, seminal prostaglandin E(2) levels were also determined. hCG stimulation increased peripheral levels of testosterone, 17OH-progesterone, androstenedione, dehydroepiandrosterone, and 17beta-estradiol, without affecting circulating pregnenolone and progesterone values. Aspirin significantly lowered seminal prostaglandin E(2) levels, whereas it did not modify steroid concentrations not exposed to exogenous hCG. Moreover, the drug significantly reduced the response of testosterone, 17OH-progesterone, androstenedione, and dehydroepiandrosterone to hCG, as assessed by the mean integrated area under the curve, whereas it did not influence 17beta-estradiol response. In conclusion, aspirin treatment inhibits androgen response to chorionic gonadotropin stimulation in normal humans. The action of aspirin is probably mediated via an effective arachidonate cyclooxygenase block.

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

“…This is in contrast to the human data, where ibuprofen, as the most potent PG synthesis inhibitor, was associated with the highest risk of congenital cryptorchidism. Acetylsalicylic acid has previously been shown to partially block the increase in testosterone production after hCG stimulation of adult men (Conte et al, 1999). A similar scenario is plausible during fetal development, which could account for the anti-androgenic effect.…”

Effects of propyphenazone and other non-steroidal anti-inflammatory agents on the synthetic and endogenous androgenic anabolic steroids urinary excretion and/or instrumental detection

“…Whereas few data are available on the possible effects of therapeutic doses of inhibitors of prostaglandins synthesis (such as for example the non-steroidal anti-inflammatory drugs) on the endocrine systems [7][8][9]. Recent studies have shown that some NSAIDs, such as for example the aspirin, influence the steroids secretion.…”

“…Recent studies have shown that some NSAIDs, such as for example the aspirin, influence the steroids secretion. In particular they have observed that the acetylsalicylic acid is able to inhibit both stimulated testosterone and other androgens secretion after human chorionic gonadotropin administration in healthy sedentary males and stress-related adenoorticotropin hormone and cortisol in healthy male athletes [7][8][9].…”

Monster Phase of Acetaminophen Use in Pregnancy: Current Vision of an Old Drug

“…But these studies involved use of APAP use over an extensive period of time; so more relevant studies should be conducted to explore whether the shorter dose also has the similar effects. Since studies conducted on this are animal studies, more studies are needed to find out how usefully this information can be transferred to human studies [44,45].…”