Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet.

Pick, Ruth; Chediak, Juan; Glick, Gerald

doi:10.1172/jci109272

Cited by 65 publications

(9 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The macaque cephalic vein is approximately 3.5-4 mm in diameter, and resembles the human saphenous vein in wall thickness and composition, unlike the delicate jugular and iliac veins used in canine studies. 4 The regimen of two antiplatelet drugs, each of which acts by a different mechanism,16 was selected because it inhibits platelet function and prolongs platelet survival in humans'7 and animals.7' , 13 We divided the 11 hyperlipemic monkeys unequally so that seven received antiplatelet therapy and four were untreated controls; our previous study showed a marked increase in the lipid uptake of grafts in untreated hyperlipemic monkeys.…”

Section: Normolipemic Monkeysmentioning

confidence: 99%

Prevention of lipid accumulation in experimental vein bypass grafts by antiplatelet therapy.

Bonchek¹,

Boerboom²,

Olinger³

et al. 1982

Circulation

View full text Add to dashboard Cite

The ameliorative effect of antiplatelet therapy on atherogenesis of vein grafts was assessed in autologous cephalic veins grafted into femoral arteries of 16 normolipemic and 11 hyperlipemic stump-tailed macaque monkeys. Before grafting, one half of each vein was distended at high pressure (700 mm Hg) and the other half at low pressure (350 mm Hg). Eight normolipemic monkeys were treated with aspirin, 80 mg/day, and dipyridamole, 50 mg/day, and eight were controls. When grafts were harvested at 12 weeks, tissue cholesterol and beta-apoprotein content in grafts from untreated monkeys were significantly higher than in ungrafted, uninjured veins. Antiplatelet therapy eliminated the increase in lipid content of vein segments distended at low pressure, and significantly lowered lipid content of segments distended at high pressure, though not to be control levels of ungrafted veins. Seven of the 11 hyperlipemic monkeys received antiplatelet drugs and four did not. The lipid content of all graft segments was significantly higher than in grafted or ungrafted veins from normolipemic monkeys. Antiplatelet therapy again significantly reduced the lipid content in vein segments distended at both levels of pressure, and also reduced the elevated cholesterol content in ungrafted veins. Although this animal preparation differs in many ways from human coronary bypass operations, these observations may be pertinent to the prevention of atherosclerosis in human vein bypass grafts.

show abstract

Section: Normolipemic Monkeysmentioning

confidence: 99%

Prevention of lipid accumulation in experimental vein bypass grafts by antiplatelet therapy.

Bonchek¹,

Boerboom²,

Olinger³

et al. 1982

Circulation

View full text Add to dashboard Cite

show abstract

“…29 " 31 The studies showing little effect have usually been short-term ones 31 or have used higher dosages of aspirin.…”

Section: Discussionmentioning

confidence: 99%

Effect of acetylsalicylic acid on pulmonary arteriosclerosis induced by a one-year Dirofilaria immitis infection.

Rawlings¹,

Keith²,

Schaub³

1985

Arteriosclerosis

View full text Add to dashboard Cite

The ability of aspirin to block arteriosclerosis that developed in response to chronic, low-level injury to pulmonary arteries was evaluated in 21 dogs during their 1-year infection with Dirofilaria immitis. Three groups, with seven dogs in each group, were studied before and after sustained injury produced by the transplantation of 28 adult Dirofilaria immitis into each dog. Group A received no treatment and served as controls; Group B received no treatment for 6 months and then received 7 mg/kg of aspirin daily) for 6 months; Group C received 7 mg/kg of aspirin daily for the entire year. The pulmonary arterial response was evaluated by hemodynamic and arteriographic studies at 6 and 12 months and by scanning electron microscopy at the end of the 12-month study. All groups developed a similar, mild pulmonary hypertension. The arteriographic changes of dilation and flow obstruction were worse in Groups A and B than in Group C at 6 months, and at 12 months both Groups B and C were less obstructed than Group A. Scanning electron microscopy revealed large, complex myointimal proliferations in Group A, whereas the two aspirin-treated groups had smaller, less complex lesions that covered a much smaller surface area. We concluded that: 1) aspirin markedly reduced the microscopic and macroscopic arteriosclerosis in Groups B and C; 2) aspirin in Group B not only arrested further development but also permitted resolution of arteriosclerosis while the arteries were still being injured. (Arteriosclerosis 5:355-365, July/August 1985)

show abstract

“…Similar inhibition by ASA was observed for the aorta and coronary arteries in swine fed a hyperlipidemic diet [Kim et al, 19831. Evaluating primates fed a hyperlipidemic diet and given high doses of aspirin, Pick et al [1979] reported reduction of lesion area in the coronary but not the aorta. Aspirin did not reduce plasma cholesterol levels.…”

Section: Antiplatelet Drugsmentioning

confidence: 99%

Current approaches to inhibition of proliferation in atherosclerosis

Handley¹

1985

Drug Development Research

View full text Add to dashboard Cite

Handley, D.A.: Current approaches to inhibition of proliferation in atherosclerosis. DrugDev. Res.6:167-176, 1985. Atherosclerosis is characterized by progressive arterial stenosis of the major vessels of the systemic circulation. In man, atherosclerotic lesions are composed principally of smooth muscle cells, connective matrix derived from these cells, and variable amounts of lipid. Emphasized is the role of the platelet mitogen, platelet-derived growth factor (PDGF), as a potent stimulus for the proliferation of smooth muscle cells in the development of atherosclerotic lesions. Animal models of proliferative atherosclerosis are reviewed, as are published references of approaches to inhibit smooth muscle cell hyperplasia in these models by drug administration. The results are discussed in terms of the potential therapeutic application of antiproliferative drugs designed to inhibit the mitogenic role of PDGF as a contributory factor in atherogenesis.

show abstract

Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet.

Cited by 65 publications

References 12 publications

Prevention of lipid accumulation in experimental vein bypass grafts by antiplatelet therapy.

Prevention of lipid accumulation in experimental vein bypass grafts by antiplatelet therapy.

Effect of acetylsalicylic acid on pulmonary arteriosclerosis induced by a one-year Dirofilaria immitis infection.

Current approaches to inhibition of proliferation in atherosclerosis

Contact Info

Product

Resources

About