Aspirin-loaded nanoexosomes as cancer therapeutics

Tran, Phuong Ha-Lien; Wang, Tao; Wang, Yin; Tran, Thao T.D.; Nguyen, Tuong N.G.; Lee, Beom‐Jin; Duan, Wei

doi:10.1016/j.ijpharm.2019.118786

Cited by 72 publications

(47 citation statements)

References 51 publications

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“…Urea is one of the major fertilizers, and CO 2 is the source for it [26]. The urea is prepared from ammonia and CO 2 in fertilizer [28] and also in fabrication process of various types of polymers, such as melamine and urea-formaldehyde resin [29][30][31][32]. Salicylic acid is produced from phenol and CO 2 via the Kolbe-Schmitt reaction [33].…”

Section: Introductionmentioning

confidence: 99%

Review on Carbon Dioxide Utilization for Cycloaddition of Epoxides by Ionic Liquid-Modified Hybrid Catalysts: Effect of Influential Parameters and Mechanisms Insight

et al. 2020

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The storage, utilization, and control of the greenhouse (CO2) gas is a topic of interest for researchers in academia and society. The present review article is dedicating to cover the overall role of ionic liquid-modified hybrid materials in cycloaddition reactions. Special emphasis is on the synthesis of various cyclic carbonate using ionic liquid-based modified catalysts. Catalytic activity studies have discussed with respect to process conditions and their effects on conversion and product selectivity for the reaction of cycloaddition of CO2 with styrene oxide. The reaction temperature and the partial pressure of CO2 have found to play a key role in cyclic carbonate formation. The role of other influential parameter (solvent effect) is also discussed for the conversion of cyclic/aromatic oxides to polycarbonate production. Our own research work that deals with ionic liquid-based halide-modified mesoporous catalyst (MCM-41 type) derived from rice husk waste has also been discussed. Finally, the role of carbon dioxide activation and ring-opening mechanisms involved in the cyclic carbonate product formation from CO2 have been discussed.

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Section: Introductionmentioning

confidence: 99%

Review on Carbon Dioxide Utilization for Cycloaddition of Epoxides by Ionic Liquid-Modified Hybrid Catalysts: Effect of Influential Parameters and Mechanisms Insight

et al. 2020

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“…With the development of new techniques for exosome isolation and preparation, some researchers have recently started using enriched or engineered exosomes as DDSs to treat CRC. For example, P. Tran et al prepared CRC cell-derived exosomes and loaded them with aspirin to generate nano-amorphous aspirin-loaded exosomes [ 202 ]. The authors observed significantly improved cytotoxicity of aspirin and enhanced apoptosis and autophagy of CRC cells using this exosome formulation.…”

Section: Delivery Routes Of Lipid-based Nanoparticles In Crc Treatmentioning

confidence: 99%

“…Importantly, these engineered nano-amorphous exosomes were found to be capable of eradicating the cancer stem cells. A further animal study proved that aspirin-loaded exosomes efficiently delivered aspirin to xenograft tumors after IV injection [ 202 ]. An active-targeting function was added to these exosomes by the conjugation of an aptamer specifically targeting the EpCAM protein on CRC cells.…”

Section: Delivery Routes Of Lipid-based Nanoparticles In Crc Treatmentioning

confidence: 99%

Lipid-Based Drug Delivery Nanoplatforms for Colorectal Cancer Therapy

Yang

Merlin

2020

Nanomaterials

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Colorectal cancer (CRC) is a prevalent disease worldwide, and patients at late stages of CRC often suffer from a high mortality rate after surgery. Adjuvant chemotherapeutics (ACs) have been extensively developed to improve the survival rate of such patients, but conventionally formulated ACs inevitably distribute toxic chemotherapeutic drugs to healthy organs and thus often trigger severe side effects. CRC cells may also develop drug resistance following repeat dosing of conventional ACs, limiting their effectiveness. Given these limitations, researchers have sought to use targeted drug delivery systems (DDSs), specifically the nanotechnology-based DDSs, to deliver the ACs. As lipid-based nanoplatforms have shown the potential to improve the efficacy and safety of various cytotoxic drugs (such as paclitaxel and vincristine) in the clinical treatment of gastric cancer and leukemia, the preclinical progress of lipid-based nanoplatforms has attracted increasing interest. The lipid-based nanoplatforms might be the most promising DDSs to succeed in entering a clinical trial for CRC treatment. This review will briefly examine the history of preclinical research on lipid-based nanoplatforms, summarize the current progress, and discuss the challenges and prospects of using such approaches in the treatment of CRC.

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“…Aspirin had been formulated with poloxamer 407 and D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) in a solid dispersion that was subsequently dispersed and accumulated in the sEVs to form a nano-amorphous matrix encapsulated sEVs through a combination of incubation, ultrasonication, and freeze-thaw methods [84]. These sEVs displayed enhanced cytotoxicity, efficient eradication of cancer stem cells, and promising targeted delivery in tumor models in vivo [115]. The membrane integrity of the sEVs frequently needs to be compromised during the process of active drug loading to ensure that the drugs can diffuse into the sEVs.…”

Section: The Application Of Lead Compounds As Drugs Loaded In Sevsmentioning

confidence: 99%

Lead Compounds in the Context of Extracellular Vesicle Research

Tran

2020

Pharmaceutics

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Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications. Physiological changes of sEVs due to the variety of cargos they carry undoubtedly leave an impression that affects the understanding of the mechanism underlying disease and the development of sEV-based shuttles used for treatments and non-invasive diagnostic tools. Indeed, the remarkable properties of sEVs are based on their nature, which helps shield them from recognition by the immune system, protects their payload from biochemical degradation, and contributes to their ability to translocate and convey information between cells and their inherent ability to target disease sites such as tumors that is valid for sEVs derived from cancer cells. However, their transport, biogenesis, and secretion mechanisms are still not thoroughly clear, and many ongoing investigations seek to determine how these processes occur. On the other hand, lead compounds have been playing critical roles in the drug discovery process and have been recently employed in studies of the biogenesis and secretion of sEVs as external agents, affecting sEV release and serving as drug payloads in sEV drug delivery systems. This article gives readers an overview of the roles of lead compounds in these two research areas of sEVs, the rising star in studies of nanoscale medicine.

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Aspirin-loaded nanoexosomes as cancer therapeutics

Cited by 72 publications

References 51 publications

Review on Carbon Dioxide Utilization for Cycloaddition of Epoxides by Ionic Liquid-Modified Hybrid Catalysts: Effect of Influential Parameters and Mechanisms Insight

Review on Carbon Dioxide Utilization for Cycloaddition of Epoxides by Ionic Liquid-Modified Hybrid Catalysts: Effect of Influential Parameters and Mechanisms Insight

Lipid-Based Drug Delivery Nanoplatforms for Colorectal Cancer Therapy

Lead Compounds in the Context of Extracellular Vesicle Research

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