Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis

Li, Peiwei; Wu, Han; Zhang, Honghe; Shi, Yu; Xu, Jun; Yao, Ye; Xia, Dajing; Yang, Jun; Cai, Jianting; Wu, Yihua

doi:10.1136/gutjnl-2014-308260

Cited by 135 publications

(113 citation statements)

References 35 publications

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“…Lastly, other molecular events or epidemiological factors within the TIL/MMR subtypes may impact prognosis or chemosensitivity, which could contribute to the observed subtype-specific survival differences. Evidence supports potential roles for APC mutation,44 chromosome instability,45 tumour-associated stroma,24 body mass index,46 smoking47 and aspirin,48 among other factors.…”

Section: Discussionmentioning

confidence: 92%

Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes

Williams

Mouradov

Jorissen

et al. 2018

Gut

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Section: Discussionmentioning

confidence: 92%

Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes

Williams

Mouradov

Jorissen

et al. 2018

Gut

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“…A new indication for aspirin as anticancer agent has been proposed in recent years [21][22][23][24][25]. This idea is mainly supported by data obtained from observational studies [26][27][28][29].…”

Section: Discussionmentioning

confidence: 94%

Acetylsalicylic Acid Exhibits Antitumor Effects in Esophageal Adenocarcinoma Cells In Vitro and In Vivo

Piazuelo

Esquivias

et al. 2016

Dig Dis Sci

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“…[30-33] The degree of lymphocytic infiltrate in CRC tissue has been associated with MSI status and better patient survival. [34-38] However, there is a paucity of data on epidemiologic exposures (such as plasma 25(OH)D level) combined with tumour molecular features and immune response in the tumour microenvironment in population-based studies.…”

Section: Discussionmentioning

confidence: 99%

Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status

Song

Nishihara

Wang

et al. 2015

Gut

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Objective Evidence suggests protective effects of vitamin D and anti-tumour immunity on colorectal cancer risk. Immune cells in tumour microenvironment can convert 25-hydroxyvitamin D [25(OH)D] to bioactive 1α,25-dihydroxyvitamin D3, which influences neoplastic and immune cells as an autocrine and paracrine factor. Thus, we hypothesised that the inverse association between vitamin D and colorectal cancer risk might be stronger for cancers with high-level immune response than those with low-level immune response. Design We designed a nested case-control study (318 rectal and colon carcinoma cases and 624 matched controls) within the Nurses’ Health Study and Health Professionals Follow-up Study, using molecular pathological epidemiology database. Multivariable conditional logistic regression was used to assess the association of plasma 25(OH)D with tumour subtypes according to the degree of lymphocytic reaction, tumour-infiltrating T-cells (CD3+, CD8+, CD45RO+ and FOXP3+ cells), microsatellite instability, or CpG island methylator phenotype. Results The association of plasma 25(OH)D with colorectal carcinoma differed by the degree of intratumoural periglandular reaction (Pheterogeneity=0.001); high 25(OH)D was associated with lower risk of tumour with high-level reaction [comparing the highest vs. lowest tertile: odds ratio, 0.10; 95% confidence interval, 0.03 to 0.35; Ptrend<0.001], but not risk of tumour with lower-level reaction (Ptrend>0.50). A statistically non-significant difference was observed for the associations of 25(OH)D with tumour subtypes according to CD3+ T-cell density (Pheterogeneity=0.03; adjusted statistical significance level of α=0.006). Conclusion High plasma 25(OH)D level is associated with lower risk of colorectal cancer with intense immune reaction, supporting a role of vitamin D in cancer immunoprevention through tumour-host interaction.

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Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis

Abstract: These findings provide further indication that postdiagnosis aspirin therapy improved CRC overall survival, especially for patients with positive PTGS2 (COX-2) expression and mutated PIK3CA tumours.

Cited by 135 publications

References 35 publications

Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes

Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes

Acetylsalicylic Acid Exhibits Antitumor Effects in Esophageal Adenocarcinoma Cells In Vitro and In Vivo

Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status

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