Aspirin use is associated with reduced risk for recurrence of pyogenic liver abscess: a propensity score analysis

Liu, Jia‐Sin; Lee, Chen‐Hsiang; Chuah, Seng‐Kee; Tai, Wei‐Chen; Chang, Cheng Fu; Chen, Fang-Ju

doi:10.1038/s41598-019-48017-3

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…Compared to male patients, female patients had a lower incidence of PLA, not only in our study but also in previous studies using the Taiwan NHIRD 6 , 18 . Biliary tract disease was reported to be associated with PLA and was much more likely to be associated with polymicrobial infections, including Escherichia coli, Enterococcus and Klebsiella species 6 , 35 .…”

Section: Discussionsupporting

confidence: 82%

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The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients

Tai

Hsu

Yang

et al. 2020

Sci Rep

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In this study, we aimed to investigate the impact of aspirin on the risk of pyogenic liver abscess caused by Klebsiella pneumoniae (KP-PLA) and invasive KP-PLA syndrome (IKPS) in diabetic patients. Diabetic patients who were propensity-score matched were retrospectively included from hospital-based database. Kaplan–Meier approach with a log-rank test was used to compare the cumulative incidences of KP-PLA including IKPS between aspirin users and non-users. Totally, 63,500 patients were analyzed after propensity-score matching (1:1). Compared with that of non-users, the incidence of KP-PLA was significantly reduced in aspirin users (0.31% vs. 0.50%, p < 0.01), but not for that of IKPS (0.02% vs. 0.03%, p = 0.29). Patients taking aspirin for ≥ 90 days had a significantly lower risk for KP-PLA (hazard ratio, 0.67; 95%CI, 0.50–0.90). Females, taking clopidogrel or metformin for ≥ 90 days, and taking H2-blockers or proton pump inhibitors (PPIs) for ≥ 5 days were also associated with a lower risk of KP-PLA. However, cholangitis and a glycated hemoglobin ≥ 8.5% were associated with an increased risk of KP-PLA.

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Section: Discussionsupporting

confidence: 82%

“…Therapeutic drugs administered for some chronic diseases may affect the recurrence of PLA in diabetic patients. Our previous study have demonstrated that aspirin could reduce the recurrence rate of PLA 18 . Aspirin can trigger lipoxin and enhances macrophage phagocytosis of bacteria 19 .…”

Section: Introductionmentioning

confidence: 93%

The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients

Tai

Hsu

Yang

et al. 2020

Sci Rep

Self Cite

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“…It has been reported that ASA can reduce capsule polysaccharide production by up to 70% [ 75 ], which resulted in the primary mechanism behind K. pneumoniae serotype K1′s increased susceptibility to leukocyte phagocytosis, preventing more invasive infections [ 76 ]. Liu et al identified 5912 patients with PLA and evaluated recurrence PLA rates between ASA users and non-users, which were 42.5 and 74.6 per 1000 person-years of follow-up, respectively [ 77 ]. Similar findings were reported in a large cohort of diabetic patients, with ASA continuous intake for >90 days associated with a lower risk of PLA [ 78 ].…”

Section: Resultsmentioning

confidence: 99%

Aspirin and Infection: A Narrative Review

et al. 2022

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Acetylsalicylic acid (ASA) is one of the most commonly used drugs in the world. It derives from the extract of white willow bark, whose therapeutic potential was known in Egypt since 1534 BC. ASA’s pharmacological effects are historically considered secondary to its anti-inflammatory, platelet-inhibiting properties; however, human studies demonstrating a pro-inflammatory effect of ASA exist. It is likely that we are aware of only part of ASA’s mechanisms of action; moreover, the clinical effect is largely dependent on dosages. During the past few decades, evidence of the anti-infective properties of ASA has emerged. We performed a review of such research in order to provide a comprehensive overview of ASA and viral, bacterial, fungal and parasitic infections, as well as ASA’s antibiofilm properties.

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“…Secondly, being a retrospective study, we were unable to systematically record the medications of patients after discharge. Therapeutic drugs administered for some chronic diseases may affect the recurrence of PLA; for example, studies have shown that aspirin can reduce the recurrence rate of PLA [24]. In addition, the patients in this study were all from a province in Northeastern China, and the epidemiology of KP may be influenced by geographic factors.…”

Section: Discussionmentioning

confidence: 99%

The increased recurrence rate of liver abscess caused by extended-spectrum β-lactamase-producing Klebsiella pneumoniae

Wang

Ren

Chang

et al. 2020

Eur J Clin Microbiol Infect Dis

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Background The pathogenic bacterium Klebsiella pneumoniae (KP) is the major causative agent of pyogenic liver abscess (PLA). But reports about the prognosis of KP-caused PLA (KPLA) are rare. This study aimed to ascertain the recurrence rate of KPLA after initial treatment, and its contributing factors. Methods The medical records data were retrospectively analyzed of KPLA patients who were admitted to Shengjing Hospital of China Medical University from January 2012 to January 2018. According to whether or not there was recurrence of KPLA during follow-up, the patients were divided into a 'recurrence' and a 'non-recurrence' group. The clinical and CT characteristics of patients were compared between the two groups, and those factors related to KPLA recurrence were further analyzed. Results A total of 110 patients who had first-time episodes of KPLA were included into the study. The average follow-up time was 3.65±2.18 years. Twenty (18.18%) KPLA patients experienced recurrence. Those in the recurrence group had a significantly greater incidence of extended-spectrum βlactamase (ESBL) production compared to the non-recurrence group (30.0% vs 8.89%, P=0.018). Diabetes, biliary tract disease, and history of malignancy was not associated with recurrence (all P>0.05). No difference in the CT characteristics of KPLA (including abscess size, location, whether multilocular, gas production of KPLA, and thrombophlebitis) was found between the two groups. Multivariate regression analysis showed that ESBL production (OR, 6.3; 95% CI, 1.02-38.59; P=0.04) was an independent risk factor for the recurrence of KPLA. Conclusions KPLA has a high recurrence rate, and ESBL production is a risk factor for recurrent KPLA.

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Aspirin use is associated with reduced risk for recurrence of pyogenic liver abscess: a propensity score analysis

Cited by 6 publications

References 26 publications

The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients

The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients

Aspirin and Infection: A Narrative Review

The increased recurrence rate of liver abscess caused by extended-spectrum β-lactamase-producing Klebsiella pneumoniae

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