Aspirin using was associated with slower cognitive decline in patients with Alzheimer’s disease

Weng, Jinyan; Zhao, Guanan; Weng, Liyan

doi:10.1371/journal.pone.0252969

Cited by 21 publications

(17 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of the link between cognitive impairment and inflammation, 6 anti‐inflammatory drugs have been deployed in the management of mild cognitive impairment and dementia. The outcomes of using non‐steroid anti‐inflammatory drugs have not proven successful, 7 although some studies have demonstrated the benefit of anti‐inflammatory therapy in mitigating the progression of cognitive impairment in human and murine models 8,9 . The failure of anti‐inflammatory drugs in alleviation of mild cognitive impairment could be because that each anti‐inflammatory agent targets a single or limited number of specific inflammatory pathways, while several cytokines and inflammatory biomarkers are elevated in the aged subjects.…”

Section: Introductionmentioning

confidence: 99%

A topical emollient mitigates the progression of cognitive impairment in the elderly: a randomized, open‐label pilot trial

Wang

Kim

et al. 2022

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background Cognitive impairment is common in the elderly. Prior studies suggest a link between chronic inflammation and cognitive dysfunction, while aging‐associated epidermal dysfunction has been connected to elevations in circulating cytokines. Objective We assessed here whether improvements in epidermal function can mitigate the progression of cognitive impairment. Methods This randomized, open‐label pilot trial was carried out in two cities in northern China. A total of 200 participants aged ≥65 years were randomly assigned to the emollient‐treated and untreated groups at 1:1 ratio. Participants in the treated group were treated topically with Atopalm cream® twice‐daily from November to the following May each year for three consecutive years, while the untreated subjects served as controls. The Global Deterioration Scale (GDS) was used to assess the severity of cognitive impairment, while epidermal biophysical properties were measured on the forearms and the shins in parallel. Results Over the three‐year trial, GDS significantly increased from baseline (P < 0.0001) in the controls, while in the treated group, GDS stabilized. While stratum corneum hydration on the forearms did not change significantly in the controls, transepidermal water loss rates (TEWL), significantly increased by the end of the trial compared to baselines in the controls (P < 0.0001). On the forearms of the treated group, stratum corneum hydration increased (P < 0.0001) while skin surface pH decreased from baseline (P < 0.0001). Conclusions These results suggest that improvements in epidermal function with topical emollient can mitigate the progression of cognitive impairment. However, the sample size was relatively small, and trials in a larger cohort are needed to validate the present results.

show abstract

Section: Introductionmentioning

confidence: 99%

A topical emollient mitigates the progression of cognitive impairment in the elderly: a randomized, open‐label pilot trial

Wang

Kim

et al. 2022

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…For example, metformin can reduce human cellular aging through upregulating GPx7 by Nrf2 signal pathway (Fang et al, 2018). Aspirin was observed to slower cognitive decline in patients with AD and to alleviate amyloid plaque pathology in an AD mouse model (Chandra et al, 2018;Weng et al, 2021). However, the effects on neuronal cell senescence are unknown in AD.…”

Section: Discussionmentioning

confidence: 99%

Alzheimer’s Amyloid-β Accelerates Human Neuronal Cell Senescence Which Could Be Rescued by Sirtuin-1 and Aspirin

Lü

et al. 2022

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Cellular senescence is a major biological process related to aging. Neuronal cell senescence contributes to the pathogenesis of many aging-related neurodegenerative diseases including Alzheimer’s disease (AD). In this study, we showed that amyloid-β42 oligomers (Aβ), one of the core pathological players of AD, significantly upregulated the expression of senescence markers, p21, plasminogen activator inhibitor-1 (PAI-1), and SA-β-gal (senescence-associated β-galactosidase) in multiple human neuronal cells, including SK-N-SH cells, SH-SY5Y cells, and neural stem cell (NSC)-derived neuronal cells. Moreover, it was consistently observed among the cells that Aβ promoted senescence-associated DNA damage as the levels of 8-OHdG staining, histone variant H2AX phosphorylation (γ-H2AX), and genomic DNA lesion increased. Mechanism study revealed that the exposure of Aβ markedly suppressed the expression of sirtuin-1 (SIRT1), a critical regulator of aging, and the exogenous expression of SIRT1 alleviated Aβ-induced cell senescence phenotypes. To our surprise, a widely used cardiovascular drug aspirin considerably rescued Aβ-induced cellular senescence at least partially through its regulation of SIRT1. In conclusion, our findings clearly demonstrate that exposure of Aβ alone is sufficient to accelerate the senescence of human neuronal cells through the downregulation of SIRT1.

show abstract

“…For example, use of non-steroidal anti-inflammatory drugs likely lowers the risk of cognitive dysfunction. [69][70][71][72][73] Likewise, glucocorticoids (potent immune suppressors) lowers the risk of dementia (HR = 0.81). 74 Similarly, administration of a TNF-a inhibitor reduces the risk of Alzheimer's disease with OR of 0.3 to 0.73.…”

Section: Basis For the Link Between Cutaneous Inflammation And Cognit...mentioning

confidence: 99%

The link between cutaneous inflammation and cognitive impairment

Wen

Elias

Wakefield-Scurr

et al. 2022

Acad Dermatol Venereol

View full text Add to dashboard Cite

Cognitive impairment is a symptom of neurological disorders, including dementia and Alzheimer's disease; and mild cognitive impairment can be a precursor of both disorders. Aged humans and animal models with other systemic disorders, such as cardiovascular diseases and diabetes, display a higher incidence of cognitive decline. Epidemiological studies have shown that the incidence of cognitive impairment also is higher in subjects with certain inflammatory skin disorders, including psoriasis and chronic eczematous dermatitis. Chronologically aged individuals exhibit increased cutaneous inflammation and elevated circulating cytokine levels, linked to alterations in epidermal function, which itself can induce cutaneous inflammation. Conversely, strategies that improve epidermal function can lower cytokine levels in both the skin and circulation. Thus, it seems likely that epidermal dysfunction could contribute, at least in part, to the development of chronic low-grade inflammation, also termed 'inflammaging', in the elderly. The evidence of cognitive impairment in patients with inflammatory dermatoses suggests a link between cutaneous inflammation and cognitive impairment. Because of the pathogenic role of epidermal dysfunction in ageing-associated cutaneous inflammation, improvements in epidermal function could be an alternative approach for mitigation of the ageing-associated decline in cognitive function.

show abstract

Aspirin using was associated with slower cognitive decline in patients with Alzheimer’s disease

Cited by 21 publications

References 32 publications

A topical emollient mitigates the progression of cognitive impairment in the elderly: a randomized, open‐label pilot trial

A topical emollient mitigates the progression of cognitive impairment in the elderly: a randomized, open‐label pilot trial

Alzheimer’s Amyloid-β Accelerates Human Neuronal Cell Senescence Which Could Be Rescued by Sirtuin-1 and Aspirin

The link between cutaneous inflammation and cognitive impairment

Contact Info

Product

Resources

About