Assembly, heterogeneity, and breaching of the basement membranes

Glentis, Alexandros; Gurchenkov, Vasily; Vignjević, Danijela

doi:10.4161/cam.28733

Cited by 112 publications

(99 citation statements)

References 86 publications

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“…This PG participates in a critical step of this system’s development, controlling neuronal growth through inhibition of neurite outgrowth [151]. Perlecan, agrin, and collagen type XVIII are examples of some PGs with structural functions at the basement membrane, an organized layer of the ECM [152-154]. …”

Section: Alterations In the Cell–cell And Cell–extracellular Matrix Imentioning

confidence: 99%

Glycobiology Modifications in Intratumoral Hypoxia: The Breathless Side of Glycans Interaction

Silva-filho¹,

Sena²,

Lima

et al. 2017

Cell Physiol Biochem

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Post-translational and co-translational enzymatic addition of glycans (glycosylation) to proteins, lipids, and other carbohydrates, is a powerful regulator of the molecular machinery involved in cell cycle, adhesion, invasion, and signal transduction, and is usually seen in both in vivo and in vitro cancer models. Glycosyltransferases can alter the glycosylation pattern of normal cells, subsequently leading to the establishment and progression of several diseases, including cancer. Furthermore, a growing amount of research has shown that different oxygen tensions, mainly hypoxia, leads to a markedly altered glycosylation, resulting in altered glycan-receptor interactions. Alteration of intracellular glucose metabolism, from aerobic cellular respiration to anaerobic glycolysis, inhibition of integrin 3α1β translocation to the plasma membrane, decreased 1,2-fucosylation of cell-surface glycans, and galectin overexpression are some consequences of the hypoxic tumor microenvironment. Additionally, increased expression of gangliosides carrying N-glycolyl sialic acid can also be significantly affected by hypoxia. For all these reasons, it is possible to realize that hypoxia strongly alters glycobiologic events within tumors, leading to changes in their behavior. This review aims to analyze the complexity and importance of glycoconjugates and their molecular interaction network in the hypoxic context of many solid tumors.

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Section: Alterations In the Cell–cell And Cell–extracellular Matrix Imentioning

confidence: 99%

Glycobiology Modifications in Intratumoral Hypoxia: The Breathless Side of Glycans Interaction

Silva-filho¹,

Sena²,

Lima

et al. 2017

Cell Physiol Biochem

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“…ECM has multiple effects on the biological behaviors of tumors 5,6. It was concluded from our previous study that the localization of the tumor in the host organism could modify the malignant phenotype of the same tumor 5…”

Section: Ecm In Tumor Progressionmentioning

confidence: 99%

“…The interaction of tumor cells and ECM components is profoundly altered at all stages of tumor progression. The microscopical injuries of basement membrane are signs of invasive growth of tumor 6,39…”

Section: Ecm Biopolymers and Their Inhibitorsmentioning

confidence: 99%

Extracellular matrix as target for antitumor therapy

Harisi¹,

Jeney²

2015

OTT

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The aim of the present review is to survey the accumulated knowledge on the extracellular matrix (ECM) of tumors referring to its putative utility as therapeutic target. Following the traditional observation on the extensive morphological alteration in the tumor-affected tissue, the well-documented aberrant cellular regulation indicated that ECM components have an active role in tumor progression. However, due to the diverse functions and variable expression of proteoglycans, matrix proteins, and integrins, it is rather difficult to identify a comprehensive therapeutic target among ECM components. At present, the elevated level of heparanase and the prominent expression of αvβ5 integrin are considered as promising therapeutic targets. The inhibition of glycosaminoglycan offers another promising approach in the treatment of those tumors which are stimulated by proteoglycans. It can be ascertained that a selective ECM inhibitor would be a great asset to control metastasis driven by ECM-mediated signaling.

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“…5 Understanding how cells pass through the physical barrier of the vascular BM is of great interest because crucial for cancer extravasation, leukocyte trafficking and angiogenic sprouting. 7,8 However, the in vivo mechanism of breaching and invasion of the vascular BM was mostly unknown for years.…”

Section: Introductionmentioning

confidence: 99%

Podosomes and invadopodia: tools to breach vascular basement membrane

Seano

Primo

2015

Cell Cycle

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T he vascular basement membrane (BM) is a thin and dense crosslinked extracellular matrix layer that covers and protects blood vessels. Understanding how cells cross the physical barrier of the vascular BM will provide greater insight into the potentially critical role of vascular BM breaching in cancer extravasation, leukocyte trafficking and angiogenic sprouting. In the last year, new evidence has mechanistically linked the breaching of vascular BM with the formation of specific cellular microdomains known as podosomes and invadopodia. These structures are specialized cell-matrix contacts with an inherent ability to degrade the extracellular matrix. Specifically, the formation of podosomes or invadopodia was shown as an important step in vascular sprouting and tumor cell extravasation, respectively. Here, we review and comment on these recent findings and explore the functions of podosomes and invadopodia within the context of pathological processes such as tumor dissemination and tumor angiogenesis.

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Assembly, heterogeneity, and breaching of the basement membranes

Cited by 112 publications

References 86 publications

Glycobiology Modifications in Intratumoral Hypoxia: The Breathless Side of Glycans Interaction

Glycobiology Modifications in Intratumoral Hypoxia: The Breathless Side of Glycans Interaction

Extracellular matrix as target for antitumor therapy

Podosomes and invadopodia: tools to breach vascular basement membrane

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