Assembly of an Injectable Noncytotoxic Peptide-Based Hydrogelator for Sustained Release of Drugs

Baral, Abhishek; Roy, Subhasish; Dehsorkhi, Ashkan; Hamley, Ian W.; Mohapatra, Saswat; Ghosh, Surajit; Banerjee, Arindam

doi:10.1021/la4043638

Cited by 146 publications

(141 citation statements)

References 68 publications

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“…Thus, this technology has the potential to reduce administration time, increase patient medication adherence and reduce therapeutic expenses 28,29. Several injectable sustained-release preparations have been developed, including for analgesic and endomyocardial applications, the steroid amcinonide, polypeptides, vaccines and gene-targeting drugs 30,31…”

Section: Discussionmentioning

confidence: 99%

Protection Provided by a Gabexate Mesylate Thermo-SensitiveIn SituGel for Rats with Grade III Pancreatic Trauma

Gao

Song

et al. 2017

Gut and Liver

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Background/AimsThis study investigated the protection provided by gabexate mesylate thermo-sensitive in-situ gel (GMTI) against grade III pancreatic trauma in rats.MethodsA grade III pancreatic trauma model with main pancreatic duct dividing was established, and the pancreas anatomical diagram, ascites, and serum biochemical indices, including amylase, lipase, C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α), were examined. The pancreas was sliced and stained with hematoxylin eosin and subjected to terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining.ResultsAscites, serum amylase, lipase, CRP, IL-6, and TNF-α levels were significantly increased in the pancreas trauma (PT) groups with prolonged trauma time and were significantly decreased after GMTI treatment. The morphological structure of the pancreas was loose, the acinus was significantly damaged, the nuclei were irregular and hyperchromatic, and there was inflammatory cell invasion in the PT group compared to the control. After GMTI treatment, the morphological structure of the pancreas was restored, and the damaged acinus and inflammatory cell invasion were decreased compared to the PT group. Moreover, the cell apoptosis index was significantly increased in the PT group and restored to the same levels as the control group after GMTI treatment.ConclusionsGMTI, a novel formulation and drug delivery method, exhibited specific effective protection against PT with acute pancreatitis therapy and has potential value as a minimally invasive adjuvant therapy for PT with acute pancreatitis.

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Section: Discussionmentioning

confidence: 99%

Protection Provided by a Gabexate Mesylate Thermo-SensitiveIn SituGel for Rats with Grade III Pancreatic Trauma

Gao

Song

et al. 2017

Gut and Liver

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“…Here, the required temperature for hydrogelation was 32-70 ο C and was shown to be concentration dependent (0.3-0.9% w/v). This delivery system was employed to separately encapsulate an antibiotic (vancomycin) or vitamin B12 and was shown to release these drugs over a two day period at physiological pH and temperature [114]. Banergi and coworkers developed stable nanovesicles (320 ± 50 nm) over a wide pH range (pH 2-12) and responsive to Ca +2 ions from dipeptides that contained a glutamic acid residue located at C-terminus and C4 lipoamino acid at N-terminus.…”

Section: Short Peptidesmentioning

confidence: 99%

“…This self-healing property is essential when designing a delivery system that has the ability to shear-thin within a syringe needle and transform back to the gel after expulsion from the syringe. Thixotropic hydrogels allow the drug to be injected directly into the targeted site without surgical implantation [114]. For example, Schneider and co-workers developed a peptide hydrogel comprised of 20 amino acids (VKVKVKVKV D P L PTKVKVKVKV-NH 2 ) with sol-gel transformation triggered by an increase in ionic strength in the presence of Dulbecco's Modified Eagle's medium buffer.…”

Section: Peptide Hydrogel Characteristicsmentioning

confidence: 99%

Recent advances in self-assembled peptides: Implications for targeted drug delivery and vaccine engineering

Eskandari

Guerin

Tóth

et al. 2017

Advanced Drug Delivery Reviews

321

220

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Self-assembled peptides have shown outstanding characteristics for vaccine delivery and drug targeting. Peptide molecules can be rationally designed to self-assemble into specific nanoarchitectures in response to changes in their assembly environment including: pH, temperature, ionic strength, and interactions between host (drug) and guest molecules. The resulting supramolecular nanostructures include nanovesicles, nanofibers, nanotubes, nanoribbons, and hydrogels and have a diverse range of mechanical and physicochemical properties. These molecules can be designed for cell-specific targeting by including adhesion ligands, receptor recognition ligands, or peptide-based antigens in their design, often in a multivalent display. Depending on their design, self-assembled peptide nanostructures have advantages in biocompatibility, stability against enzymatic degradation, encapsulation of hydrophobic drugs, sustained drug release, shear-thinning viscoelastic properties, and/or adjuvanting properties. These molecules can also act as intracellular transporters and respond to changes in the physiological environment. Furthermore, this class of materials has shown sequence- and structure-dependent impacts on the immune system that can be tailored to non-immunogenic for drug targeting, and immunogenic for vaccine delivery. This review explores self-assembled peptide nanostructures (beta sheets, alpha helices, peptide amphiphiles, amino acid pairing, elastin like polypeptides, cyclic peptides, short peptides, Fmoc peptides, and peptide hydrogels) and their application in vaccine delivery and drug targeting.

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“…For example, Banerjee and coworkers developed a cell-compatible synthetic tripeptide-based hydrogel with similar mechanical properties for entrapment and sustained release of an antibiotic vancomycin and vitamin B12 at physiological pH. [102] Moreover, due to their transient nature, the formed supramolecular hydrogels ultimately dissociate after certain period, which minimizes long-term toxicity.…”

Section: Supramolecular Hydrogels As Biofunctional Materialsmentioning

confidence: 99%

“…The drugs or bioactive molecules can be either physically entrapped within the inert hydrogel matrix/scaffold or chemically conjugated to the self-assembling molecules. Thus, the applications of supramolecular hydrogels as drug delivery vehicles mainly fall into two categories: i) drugs encapsulated in hydrogels;[102, 262–277] ii) drugs conjugate covalently with the hydrogelators. [278–283]…”

Section: Applications Of Supramolecular Biofunctional Materialsmentioning

confidence: 99%

Supramolecular biofunctional materials

et al. 2017

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This review discusses supramolecular biofunctional materials, a novel class of biomaterials formed by small molecules that are held together via noncovalent interactions. The complexity of biology and relevant biomedical problems not only inspire, but also demand effective molecular design for functional materials. Supramolecular biofunctional materials offer (almost) unlimited possibilities and opportunities to address challenging biomedical problems. Rational molecular design of supramolecular biofunctional materials exploit powerful and versatile noncovalent interactions, which offer many advantages, such as responsiveness, reversibility, tunability, biomimicry, modularity, predictability, and, most importantly, adaptiveness. In this review, besides elaborating on the merits of supramolecular biofunctional materials (mainly in the form of hydrogels and/or nanoscale assemblies) resulting from noncovalent interactions, we also discuss the advantages of small peptides as a prevalent molecular platform to generate a wide range of supramolecular biofunctional materials for the applications in drug delivery, tissue engineering, immunology, cancer therapy, fluorescent imaging, and stem cell regulation. This review aims to provide a brief synopsis of recent achievements at the intersection of supramolecular chemistry and biomedical science in hope of contributing to the multidisciplinary research on supramolecular biofunctional materials for a wide range of applications. We envision that supramolecular biofunctional materials will contribute to the development of new therapies that will ultimately lead to a paradigm shift for developing next generation biomaterials for medicine.

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Assembly of an Injectable Noncytotoxic Peptide-Based Hydrogelator for Sustained Release of Drugs

Cited by 146 publications

References 68 publications

Protection Provided by a Gabexate Mesylate Thermo-SensitiveIn SituGel for Rats with Grade III Pancreatic Trauma

Protection Provided by a Gabexate Mesylate Thermo-SensitiveIn SituGel for Rats with Grade III Pancreatic Trauma

Recent advances in self-assembled peptides: Implications for targeted drug delivery and vaccine engineering

Supramolecular biofunctional materials

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