Assembly of graphene oxide multilayer film for stable and sustained release of nitric oxide gas

Tanum, Junjira; Jeong, Hyejoong; Heo, Jiwoong; Choi, Min Jeong; Park, Kyungtae; Hong, Jinkee

doi:10.1016/j.apsusc.2019.04.260

Cited by 19 publications

(13 citation statements)

References 59 publications

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“…The materials are composed of polymers, dendrimers, inorganic materials, or carbon-based composites. One notable feature of these materials is that most of them contain a NO-donor moiety based on N -diazeniumdiolate that functions as the NO-loading site, − although zeolites and organoclays are functioned by complexation and the specific interaction, respectively. , We present a different concept, both in our previous report and in the present work, in which void volumes presented in 2D hierarchically organized layers and hierarchy and in 3D concentric hierarchies are the main sites for NO loading. As a consequence, the NO payload is high (e.g., reaching 417.4 and 311.9 μmol mg –1 for NG/DEN- F / F -PEG and NCNH/DEN- F / F -PEG, respectively).…”

Section: Resultsmentioning

confidence: 65%

Nitric Oxide Gas in Carbon Nanohorn/Fluorinated Dendrimer/Fluorinated Poly(ethylene glycol)-Based Hierarchical Nanocomposites as Therapeutic Nanocarriers

Krathumkhet

Sabrina

Imae

et al. 2021

ACS Appl. Bio Mater.

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Nitric oxide (NO) gas nanocarrier materials were prepared via a hierarchical assembly of poly(amido amine) dendrimers with fluorocarbon binding sites (DEN-F) and fluorinated poly(ethylene glycol) (F-PEG) on nitrogen-doped carbon nanohorns (NCNHs). The loading abilities of NO gas in these nanocarrier materials increased with the nitrogen doping of CNH and hierarchies formed by DEN-F and F-PEG. Especially, the ability of CNH-based nanocomposite materials was better than that of graphene-based materials. The loading of NO gas arose an infrared absorption band at 1387 cm–1 and increased the intensity ratio of D and G bands in Raman spectra, although these phenomena diminished after the degas treatment. The antimicrobial effects on bacteria (Escherichia coli and Staphylococcus aureus) increased depending on the loading amount of NO gas. It was confirmed from these results that NO gas weakly interacts with nitrogen-doped CNH and is trapped in the void volumes of DEN-F and F-PEG hierarchies. Thus, the concentric hierarchy is preferable for slow release of NO gas due to the void volumes in DEN-F, F-PEG, and CNH hierarchical organization. This sustained release of NO gas is advantageous with regards to the potential biomedical gas therapy against bacteria and other parasites.

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Section: Resultsmentioning

confidence: 65%

Nitric Oxide Gas in Carbon Nanohorn/Fluorinated Dendrimer/Fluorinated Poly(ethylene glycol)-Based Hierarchical Nanocomposites as Therapeutic Nanocarriers

Krathumkhet

Sabrina

Imae

et al. 2021

ACS Appl. Bio Mater.

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“…However, there are many other biodegradable, biocompatible polymers obtained from renewable sources to be used, such as lignin, alginate, cellulose and zein (Darder et al ., 2020; Urzedo et al ., 2020; Low et al ., 2021). In addition to polymeric nanoparticles, there are different classes of nanomaterials for NO incorporation (via nanoencapsulation or surface functionalization) as liposomes (Suchyta & Schoenfisch, 2015), metal/metal oxide nanoparticles coated with organic matrix (Santos et al ., 2016; Pieretti et al ., 2021), and carbon‐based nanomaterials (Tanum et al ., 2019; Jin et al ., 2021) (Fig. 1b).…”

Section: Figmentioning

confidence: 99%

Nitric oxide‐releasing nanomaterials: from basic research to potential biotechnological applications in agriculture

et al. 2022

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Nitric oxide (NO) is a multifunctional gaseous signal that modulates the growth, development and stress tolerance of higher plants. NO donors have been used to boost plant endogenous NO levels and to activate NO-related responses, but this strategy is often hindered by the relative instability of donors. Alternatively, nanoscience offers a new, promising way to enhance NO delivery to plants, as NOreleasing nanomaterials (e.g. S-nitrosothiol-containing chitosan nanoparticles) have many beneficial physicochemical and biochemical properties compared to non-encapsulated NO donors. Nano NO donors are effective in increasing tissue NO levels and enhancing NO effects both in animal and human systems. The authors believe, and would like to emphasize, that new trends and technologies are essential for advancing plant NO research and nanotechnology may represent a breakthrough in traditional agriculture and environmental science. Herein, we aim to draw the attention of the scientific community to the potential of NO-releasing nanomaterials in both basic and applied plant research as alternatives to conventional NO donors, providing a brief overview of the current knowledge and identifying future research directions. We also express our opinion about the challenges for the application of nano NO donors, such as the environmental footprint and stakeholder's acceptance of these materials.

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“…As reported in Table 2, S-nitroso-N-acetyl penicillamine, SNAP, is the most frequently used RSNO for the functionalization strategy based on material impregnation. Indeed, this NO donor is a suitable choice because of its positive partition [36] Copyright 2021, Elsevier. Antibacterial effect and anti-platelet adhesion 99.99% and 88% reduction of S. aureus and platelets adhesion [54] GSNO, S-nitrosoglutathione; SNAP, S-nitroso-N-acetylpenicillamine.…”

Section: Entrapped Rsno: Materials Impregnation With Liquid Rsnomentioning

confidence: 99%

“…Tanum and co‐workers ( Figure ) reported multilayered films with a sustained release of NO provided amine stabilization combined with gas barrier properties of graphene oxide (GO). [ 36 ] GO was functionalized with tetraethylenepentamine or pentaethylenehexamine. These molecules contain several secondary amines, for NONOates formation, and as well as two primary amines at their ends allowing an amide linkage with GO through a carbodiimide coupling and also conferring a positive charge to GO.…”

Section: No Deliverymentioning

confidence: 99%

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Nitric Oxide Delivering Surfaces: An Overview of Functionalization Strategies and Efficiency Progress

Beurton

Boudier

Seabra

et al. 2022

Adv Healthcare Materials

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An overview on the design of nitric oxide (NO) delivering surfaces for biomedical purposes is provided, with a focus on the advances of the past 5 years. A localized supply of NO is of a particular interest due to the pleiotropic biological effects of this diatomic compound. Depending on the generated NO flux, the surface can mimic a physiological release profile to provide an activity on the vascular endothelium or an antibacterial activity. Three requirements are considered to describe the various strategies leading to a surface delivering NO. Firstly, the coating must be selected in accordance with the properties of the substrate (nature, shape, dimensions…). Secondly, the releasing and/or generating kinetics of NO should match the targeted biological application. Currently, the most promising structures are developed to provide an adaptable NO supply driven by pathophysiological needs. Finally, the biocompatibility and the stability of the surface must also be considered regarding the expected residence time of the device. A critical point of view is proposed to help readers in the design of the NO delivering surface according to its expected requirement and therapeutic purpose.

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Assembly of graphene oxide multilayer film for stable and sustained release of nitric oxide gas

Cited by 19 publications

References 59 publications

Nitric Oxide Gas in Carbon Nanohorn/Fluorinated Dendrimer/Fluorinated Poly(ethylene glycol)-Based Hierarchical Nanocomposites as Therapeutic Nanocarriers

Nitric Oxide Gas in Carbon Nanohorn/Fluorinated Dendrimer/Fluorinated Poly(ethylene glycol)-Based Hierarchical Nanocomposites as Therapeutic Nanocarriers

Nitric oxide‐releasing nanomaterials: from basic research to potential biotechnological applications in agriculture

Nitric Oxide Delivering Surfaces: An Overview of Functionalization Strategies and Efficiency Progress

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