Assembly of magnetic nanoparticles at a liquid/liquid interface. Catalytic effect on ion transfer process

Cámara, Candelaria Inés; Monzón, Lorena M. A.; Coey, J. M. D.; Yudi, Lidia Mabel

doi:10.1016/j.jelechem.2015.06.020

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…After 24 h drug exposure durations, the medium was substituted with 200 lL fresh RPMI-1640 medium for 24 h. The cells were incubated with 50 lL of 2 mg/ml MTT which dissolved in PBS, for 4 h. Then, the content of all wells was replaced with 200 lL pure DMSO and 25 lL Sorensen's glycine buffer. Finally, in a reference wavelength of 630 nm, an ELISA-reader was used to estimate the absorbance measurement at 570 nm (Baviskar et al 2012, C amara et al 2014, Cervadoro et al 2013, Gudoshnikov et al 2012, 2013, Martinez-Boubeta et al 2013, Thakor et al 2013.…”

Section: Ee ¼mentioning

confidence: 99%

Preparation and characterization of PLGA-β-CD polymeric nanoparticles containing methotrexate and evaluation of their effects on T47D cell line

Gorjikhah

Jalalian

Salehi

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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Among all cancers that affect women, breast cancer has most mortality rate. It is essential to attain more safe and efficient anticancer drugs. Recent advances in medical nanotechnology and biotechnology have caused in novel improvements in breast and other cancer drug delivery. Methotrexate is an anticancer drug that prevents the dihydrofolate reductase enzyme, which inhibits in the formation of DNA, RNA and proteins which have poor water-solubility. For enhancing the solubility and stability of drugs in delivery systems, we used methotrexate-loaded PLGA- beta-cyclodextrin nanoparticles. The PLGA- beta-cyclodextrin nanoparticles were synthesized by a double emulsion method and characterized with FT-IR and SEM. T47D breast cancer cell lines were treated with equal concentrations of methotrexate-loaded PLGA- beta-cyclodextrin nanoparticles and free methotrexate. MTT assay confirmed that methotrexate-loaded PLGA- beta-cyclodextrin nanoparticles enhanced cytotoxicity and drug delivery in T47D breast cancer cells. These results indicate that encapsulated drugs could be effective in controlled drug release for a sustained period would serve the purpose for long-term treatment of many diseases such as breast cancer.

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