Assembly of Nanoparticle–Protein Binding Complexes: From Monomers to Ordered Arrays

Hu, Minghui; Qian, Luping; Briñas, Raymond P.; Lymar, Elena S.; Hainfeld, James F.

doi:10.1002/anie.200701180

Cited by 55 publications

(38 citation statements)

References 39 publications

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“…[16,17 ] Self assembling systems offer convenient yet powerful bottom-up strategies for the creation of nanostructures that can be deployed in the realization of functional nanoscale devices. [18,19 ] The utilization of biomolecules such as DNA, [3, 20 -24 ] and protein-based materials [25][26][27] or viruses [28,29 ] to dictate the organization of nanoparticles has been shown to be an effective and robust paradigm. The use of peptide-based structures [30,31 ] in nanotechnology confers numerous advantages such as the specification of assembled nanostructure by changes in the primary sequence of the peptide, as well as the adoption of various hierarchical morphologies in solution.…”

mentioning

confidence: 99%

One‐Dimensional Gold Nanoparticle Arrays by Electrostatically Directed Organization Using Polypeptide Self‐Assembly

et al. 2009

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The study of interactions between particles organized in a linear configuration is interesting from a quantum mechanical perspective, and the anisotropic properties of linear assemblies is of potential interest for the development of solid-state devices. [1][2][3] This anisotropy may be manifested as a difference in the magnetization and coercivity obtained in a magneticnanoparticle array when a field is applied along the chain or orthogonal to it. [4,5 ] Nonlinear electrical characteristics [3] or dichroism in the optical spectra with longitudinal and transverse polarizations of light [6,7 ] in metal nanoparticle arrays are other examples of such anisotropy, and the construction of such arrays would offer opportunities in multiple applications. Engineering matter at submicron length scales has been an area largely dominated by top-down methodologies. Control of interparticle spacing in metal-nanoparticle arrays by using techniques such as electron beam lithography has been found to have a dramatic impact on the optical response of the nanoparticle assembly, [8][9][10] ] and has implications in fields such as plasmonics [11] and energy transport. [12,13 ] The use of templates such as carbon nanotubes [14] and linear pores[15] to construct one-dimensional nanostructures has been demonstrated previously. In addition, polymers have recently begun to play an increasingly active role as elements that can reproducibly direct the arrangement of nanoparticles into functional geometries. [16,17 ] Self assembling systems offer convenient yet powerful bottom-up strategies for the creation of nanostructures that can be deployed in the realization of functional nanoscale devices. [18,19 ] The utilization of biomolecules such as DNA, [3, 20 -24 ] and protein-based materials [25][26][27] or viruses [28,29 ] to dictate the organization of nanoparticles has been shown to be an effective and robust paradigm. The use of peptide-based structures [30,31 ] in nanotechnology confers numerous advantages such as the specification of assembled nanostructure by changes in the primary sequence of the peptide, as well as the adoption of various hierarchical morphologies **

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mentioning

confidence: 99%

One‐Dimensional Gold Nanoparticle Arrays by Electrostatically Directed Organization Using Polypeptide Self‐Assembly

et al. 2009

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“…Differently from the previously reported procedures (Du Roure et al 2003;Hu et al 2007;Schmitt et al 1994), a modified synthesis procedure is herein developed and described as follows. Firstly, 3.64 g (15 mmol) L-cystine is dissolved in 75 mL of 2 M NaOH and the solution is added dropwise (within 10 min, with stirring) into a cooled solution (at 0°C) of 16.67 g (240 mmol) bromoacetic acid in 2 M NaOH (120 mL).…”

Section: Synthesis Of Nta Derivative Based Cystinementioning

confidence: 99%

A chelating-bond breaking and re-linking technique for rapid re-immobilization of immune micro-sensors

et al. 2011

Biomed Microdevices

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With high sensitivity and specificity to antigen, immune micro-sensors can be used in rapid detection of pathogenic microbial. This study proposes and develops a method for rapidly regeneration of antibody on a resonant micro-cantilever sensor. A nitrilotriacetic acid (NTA) derivative is synthesized with cystine and bromoacetic acid, then added with 2-mercaptoethanol to prepare a mixed self-assembled monolayer (SAM) on Au (111) surface of the cantilever. Ni²⁺ ions are thereafter chelated on the mixed SAM to form a breakable and re-linkable chelating-bond layer. Repeatable cycles of antibody immobilization and erasing are experimentally validated with a detectable marker of synthesized biotinylated poly peptides harboring six histidine residues (named as His-Bio). Two distinguished pathogenic microbial, Escherichia. coli O157:H7 and Bacillus Anthracis, are detected with the rapidly regenerated sensor. The E. coli O157:H7 sensor exhibits a three-time repeated detection to the 10³ CFU/ml concentration microbial. Then, an E. coli O157:H7 sensor is eluted with Tris-HCl (20 mM Tris, 150 mM NaCl, 0.1% Tween 20, pH = 3.0) and rapidly reconstructed into a B. Anthracis sensor by changing the re-immobilized antibody. The cantilever sensor no longer responses to E. coli O157:H7 even in a high concentration of 10⁷ CFU/ml. In contrast, the sensor is experimentally confirmed being resoluble to low concentration B. Anthracis at 10³ spores/ml level. The proposed fast regeneration method is promising in repeatedly or multi-target detection applications of micro/nano immune-sensors, e.g. the resonant micro-cantilevers.

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“…Such plasma protein repellent stabilizers can be employed as an alternative to overcome the existence of limitations of PEG coating or PEGylation in therapeutic applications. A recent report of NP–histodine complexes demonstrated that the orientation, geometry and stoichiometry and its specificity can be regulated by the size and binding sites on the NP’s surface [80]. …”

Section: Factors Influence Curcumin Nanoparticleplasma Protein Coronamentioning

confidence: 99%

Plasma Proteins Interaction with Curcumin Nanoparticles: Implications in Cancer Therapeutics

Yallapu¹,

Ebeling²,

Jaggi³

et al. 2013

CDM

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Curcumin, a natural bioactive polyphenol, has been widely investigated as a conventional medicine for centuries. Over the past two decades, major pre-clinical and clinical trials have demonstrated its safe therapeutic profile but clinical translation has been hampered due to rapid degradation, poor water solubility, bioavailability and pharmaco-kinetics. To overcome such translational issues, many laboratories have focused on developing curcumin nanoformulations for cancer therapeutics. In this review, we discuss the evolution of curcumin nanomedicine in cancer therapeutics, the possible interactions between the surface of curcumin nanoparticles and plasma proteins, the role of nanoparticle-protein complex architecture parameters, and the rational design of clinically useful curcumin nanoformulations. Considering all the biologically relevant phenomena, curcumin nanoformulations can be developed as a new neutraceutical or pharmaceutical agent.

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Assembly of Nanoparticle–Protein Binding Complexes: From Monomers to Ordered Arrays

Cited by 55 publications

References 39 publications

One‐Dimensional Gold Nanoparticle Arrays by Electrostatically Directed Organization Using Polypeptide Self‐Assembly

One‐Dimensional Gold Nanoparticle Arrays by Electrostatically Directed Organization Using Polypeptide Self‐Assembly

A chelating-bond breaking and re-linking technique for rapid re-immobilization of immune micro-sensors

Plasma Proteins Interaction with Curcumin Nanoparticles: Implications in Cancer Therapeutics

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