Assembly strategy of liposome and polymer systems for siRNA delivery

Song, Huiling; Hart, Stephen L.; Du, Zongliang

doi:10.1016/j.ijpharm.2020.120033

Cited by 44 publications

(26 citation statements)

References 113 publications

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“…In addition, siRNA complexation with cationic polymers via electrostatic interactions has been largely studied [56][57][58]. However, this approach suffers from some limitations, such as the stability issue in biological fluids, low transfection efficiency, and toxicity problems [45,55,59].…”

Section: Characterization Of Sinrf2-nanobubble Formulationsmentioning

confidence: 99%

Ultrasound-Responsive Nrf2-Targeting siRNA-Loaded Nanobubbles for Enhancing the Treatment of Melanoma

et al. 2022

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The siRNA-mediated inhibition of nuclear factor E2-related factor 2 (Nrf2) can be an attractive approach to overcome chemoresistance in various malignant tumors, including melanoma. This work aims at designing a new type of chitosan-shelled nanobubble for the delivery of siRNA against Nrf2 in combination with an ultrasound. A new preparation method based on a water–oil–water (W/O/W) double-emulsion was purposely developed for siRNA encapsulation in aqueous droplets within a nanobubble core. Stable, very small NB formulations were obtained, with sizes of about 100 nm and a positive surface charge. siRNA was efficiently loaded in NBs, reaching an encapsulation efficiency of about 90%. siNrf2-NBs downregulated the target gene in M14 cells, sensitizing the resistant melanoma cells to the cisplatin treatment. The combination with US favored NB cell uptake and transfection efficiency. Based on the results, nanobubbles have shown to be a promising US responsive tool for siRNA delivery, able to overcome chemoresistance in melanoma cancer cells.

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Section: Characterization Of Sinrf2-nanobubble Formulationsmentioning

confidence: 99%

Ultrasound-Responsive Nrf2-Targeting siRNA-Loaded Nanobubbles for Enhancing the Treatment of Melanoma

et al. 2022

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“…Results obtained showed that the encapsulated formulation has higher efficiency than Doxorubicin. [153] The polyphenol drugs Naringenin, Quercetin, and Curcumin were formulated as a cumulative drug delivery carrier using a functionalized nanohybrid hydrogel containing L-Histidine (HIS) conjugated chitosan, phytosynthesized zinc oxide nanoparticles, and dialdehyde cellulose. This system showed higher encapsulation efficiency, sustained drug delivery and higher toxicity towards A431 cells.…”

Section: Chemistryselectmentioning

confidence: 99%

Brief Outlook on Polymeric Nanoparticles, Micelles, Niosomes, Hydrogels and Liposomes: Preparative Methods and Action

2022

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Polymeric nanoparticles, micelles, niosomes, hydrogels and liposomes represent effective drug carriers having huge potential for medical and pharmaceutical applications. These systems remain the most important area in medicinal chemistry research. The aforementioned biomaterials can effectively encapsulate and release diverse hydrophobic/hydrophilic therapeutic molecules including drugs and prodrugs. Applications of these carrier systems extend to nucleic acids, antibodies and proteins which could be released sustainably. Since these systems fall in the nano dimension, they are capable of enhancing the therapeutic efficacy of bioactive molecules besides enabling them to accumulate preferentially at the target site. Furthermore, these systems can protect the encapsulated drug from degradation, thereby increasing the therapeutic value of the drug candidate and reducing systemic toxicity. In this review, we illustrate the preparative methods and actions of these five drug delivery systems.

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“…The selection of different ligands that are connected with liposomes can be targeted to different receptor-positive targets. The ligands of liposomes can be selected according to the needs of drug administration [ 120 , 121 , 122 ]. Class D systems are integrated therapeutic liposomes composed of nanoparticles, target units and contrast agents.…”

Section: Membrane Proteins and Their Applications In The Treatment Of Diseasesmentioning

confidence: 99%

Specifically Targeted Transport of Plasma Membrane Transporters: From Potential Mechanisms for Regulating Cell Health or Disease to Applications

2021

Membranes

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Normal substrate transport and signal transmission are the premise to ensure the health of biological somatic cells. Therefore; a comprehensive understanding of the molecular mechanism of intercellular substrate transport is of great significance for clinical treatment. In order to better understand the membrane protein through its interaction with receptors, to help maintain a healthy cell and the molecular mechanisms of disease, in this paper, we seek to clarify, first of all, the recognition mechanism for different types of membrane protein receptors; pathogen invasion using the transport pathway involved in the membrane; and the latest specific target sites of various kinds of membrane transport carriers; to provide an explanation and summary of the system. Secondly; the downstream receptor proteins and specific substrates of different membrane transporters were classified systematically; the functional differences of different subclasses and their relationship with intracellular transport disorders were analyzed to further explore the potential relationship between cell transport disorders and diseases. Finally, the paper summarizes the use of membrane transporter-specific targets for drug design and development from the latest research results; it points out the transporter-related results in disease treatment; the application prospects and the direction for drug development and disease treatment providing a new train of thought; also for disease-specific targeted therapy, it provides a certain reference value.

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Assembly strategy of liposome and polymer systems for siRNA delivery

Cited by 44 publications

References 113 publications

Ultrasound-Responsive Nrf2-Targeting siRNA-Loaded Nanobubbles for Enhancing the Treatment of Melanoma

Ultrasound-Responsive Nrf2-Targeting siRNA-Loaded Nanobubbles for Enhancing the Treatment of Melanoma

Brief Outlook on Polymeric Nanoparticles, Micelles, Niosomes, Hydrogels and Liposomes: Preparative Methods and Action

Specifically Targeted Transport of Plasma Membrane Transporters: From Potential Mechanisms for Regulating Cell Health or Disease to Applications

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