Assess the Awareness and Attitude Regarding Prevention of Coronavirus Disease 2019

Missriya, Sahbanathul; Hassan, Suhail

doi:10.22159/ajpcr.2020.v13i7.37804

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…The advent of SARS-Cov-2 and its subsequent spread has overshadowed all the alerts and has caused an emerging global and economic crisis in public health. In the absence of specific treatment options, only non-pharmaceutical interventions in the medical and public health community could focus on to reduce COVID-19 burden [68,69]. Such initiatives are aimed at preventing disease transmission locally and internationally, by banning public gatherings, imposing stay-at-…”

Section: Healthmentioning

confidence: 99%

A Systematic Review on Enhanced Transmission and Effects of Severe Acute Respiratory Syndrome Coronavirus-2: An Indian Scenario

Prashanth

Sumana

Patil

et al. 2020

Asian J Pharm Clin Res

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The outbreak of severe acute respiratory syndrome coronavirus-2 in Wuhan city of China has taken the entire world to an appalling situation with its detrimental effects on the mankind. Due to the facts on epidemiological and clinical features, it has become evident that the virus comprises several evolutionary factors that enhance its transmissibility and infection. In the absence of specific treatment options, many of the countries have implemented the confinement at varying levels and restrictions to control further infection. In the context, impact of confinement has affected different sectors including economy, social life, environment, health, and education, By virtue of the interrelated mechanism of functioning, these sectors have been ineffective, which, in turn, has affected the normal human lifestyle. This review emphasizes on such social sectors of India, where public life has been facing detrimental effects. It also highlights the facts that are responsible for the enhanced transmission of the virus. The review was initiated with a literature search using PubMed, Google Scholar, EMBASE, and Web of Science, where related keywords were used to collect 259 studies, and 82 of them were finalized based on relevance and information within. It was completed with equal contributions from all the authors in terms of preparing the manuscript.

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Section: Healthmentioning

confidence: 99%

A Systematic Review on Enhanced Transmission and Effects of Severe Acute Respiratory Syndrome Coronavirus-2: An Indian Scenario

Prashanth

Sumana

Patil

et al. 2020

Asian J Pharm Clin Res

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Molecular Docking of Selected Bioactive Compounds From Azadirachta Indica for the Inhibition of Covid19 Protease

Sharon¹

2020

Int J Pharm Pharm Sci

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Objective: COVID-19 caused by novel SARS-coronavirus 2 belonging to family Coronaviridae, is a global public health emergency infecting many people all around the world, especially in India with more than 2,98,000 cases. Hence there is a need for a novel drug that counters SARS-CoV2 is the prime requirement at this time. Methods: The present study aimed to assess bioactive compounds found in Azadirachta indica as a potential inhibitor of COVID-19 Mpr °(6Y2E, 6LU7, and 2GTB) by Autodock 4.2, with the Lamarckian Genetic Algorithm. COVID-19 Mpr ° was docked with thirteen bioactive compounds, and docking was analyzed by Autodock 4.2 and Pymol. Nelfinavir and Saquinavir were used as positive standards for comparison. Results: Azadirachtanin, Azadirachtol, and Salannolide, were left out because of the violation of Lipinski’s rule. The binding energies obtained from the docking of 6Y2E with a native ligand, Azadiradione, Beta-sitosterol, Epiazadiradione, Epoxyazadiradione, Kaempferol, Meldenin, Myricetin, Nimbaflavone, Nimbinene, Nimbione, Nimbocinolide, Quercitrin, Vepnin, Saquinavir, and Nelfinavir were-7.32,-6.63,-6.69,-7.52,-5.27,-4.54,-6.07,-4.19,-5.02,-5.58,-6.23,-4.71, -3.72,-6.4,-7.14 and-4.67 kcal/mol respectively. The binding energies obtained from the docking of 6LU7 with the native ligand, Azadiradione, Nimbione, Vepnin, and Saquinavir were-6.14,-6.48,-6.79 and-6.49 kcal/mol correspondingly. The binding energies obtained from the docking of 2GTB with the native ligand, Azadiradione, Epiazadiradione, Epoxyazadiradione, Kaempferol, Meldenin, Myricetin, Nimbaflavone, Nimbione, Nimbocinolide, Quercitrin, Vepnin, Saquinavir, and Nelfinavir were-6.96,-7.13,-6.69,-5.22,-6.44,-5.06,-5.93,-6.66,-5.3,-5.63,-7.11,-6.89 and-5.42kcal/mol, respectively. Conclusion: Azadiradione, Epiazadiradione, Nimbione, and Vepnin seemed to have the greatest potential to act as COVID-19 protease inhibitors. However, further research is necessary to explore their prospective medicinal use in vitro and in vivo conditions.

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Comprehensive Therapeutic Interventions Against Sars-Cov-2: A Review and Prospective

PRASAD

2022

Int J Pharm Pharm Sci

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In December 2019, Wuhan City, Hubei Province, China, first reported pneumonia like symptoms with unknown aetiology caused by a novel coronavirus. The novel coronavirus was renamed as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by Coronaviridae Study Group of the International Committee on Taxonomy of Viruses and the disease was termed as Coronavirus Disease 2019 (COVID-19). As of 19 August, 2022, the infection has reached above 220 countries, areas or territories with a total of 591 683 619 confirmed cases and 6 443 306 deaths, as published by the World Health Organization (WHO). SARS-CoV-2 is strongly contagious as it has R0, 2.2-2.6, in comparison to SARS-CoV (<1) and Middle East respiratory syndrome coronavirus (MERS-CoV) (1.4-2.5), respectively. SARS-CoV-2 might become less virulent than the SARS-CoV and MERS-CoV, with the currently analyzed mortality of COVID-19 is 3.4%. The original SARS-CoV-2 has undergone “virus evolution” with the occurrence of numerous variants such as Alpha, Beta, Gamma and Delta etc. Recently, the circulating variant of concern is Omicron subvariants. Currently, real-time reverse transcription–polymerase chain reaction-based detection of the viral genome (RNA) is the gold standard for diagnosis of SARS-CoV-2 infection. At present, Remdesivir (RDV) and Baricitinib drugs as well as vaccines Pfizer-BioNTech and Moderna have been approved for the treatment of COVID-19 by Food and Drug Administration (FDA). In this review, we summarized the existing state of knowledge on approved antiviral therapy, combination therapy, blood-derived therapeutics and immunomodulators to treat COVID-19 pandemic.

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Assess the Awareness and Attitude Regarding Prevention of Coronavirus Disease 2019

Cited by 4 publications

References 24 publications

A Systematic Review on Enhanced Transmission and Effects of Severe Acute Respiratory Syndrome Coronavirus-2: An Indian Scenario

A Systematic Review on Enhanced Transmission and Effects of Severe Acute Respiratory Syndrome Coronavirus-2: An Indian Scenario

Molecular Docking of Selected Bioactive Compounds From Azadirachta Indica for the Inhibition of Covid19 Protease

Comprehensive Therapeutic Interventions Against Sars-Cov-2: A Review and Prospective

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