Assessing effect of anaesthetic methods on postoperative cognitive dysfunction

Shao, Liu-Jia-Zi; Xue, Fu‐Shan; Guo, Renhua; Zheng, Lirong

doi:10.1177/0310057x18823764

Anaesth Intensive Care

2019

DOI: 10.1177/0310057x18823764

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Assessing effect of anaesthetic methods on postoperative cognitive dysfunction

Liu-Jia-Zi Shao

Fu‐Shan Xue

Renhua Guo

et al.

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2020

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“…Anesthesia and surgery have relations with brief or long-time deterioration in cognition condition, which was named postoperative cognitive dysfunction (POCD) [1,2]. POCD occurs more commonly in elderly people, because aging has been considered the most important risk factor in its course [3,4].…”

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Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats

Wang

Zhang

et al. 2020

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Postoperative cognitive dysfunction is a common complication in elderly patients after surgeries involving anesthesia, but the underlying mechanisms are poorly understood. Lithium is a conventional treatment for bipolar disorder, which exerts a neuroprotective role in various diseases by inhibiting glycogen synthase kinase‐3β (GSK‐3β) in the brain and spinal cord. However, it is not known whether lithium chloride (LiCl) can protect against cognitive dysfunction induced by sevoflurane (SEV) anesthesia. Here, we examined the effects of LiCl on SEV‐induced cognitive dysfunction in rats and on SEV‐induced neuron apoptosis. We report that anesthesia with SEV significantly impaired memory performance, induced oxidative stress and hippocampal neuron apoptosis, and stimulated GSK‐3β activity. Treatment with LiCl ameliorated SEV‐induced cognitive disorder in rats by inhibiting the GSK‐3β/β‐catenin signaling pathway. In addition, LiCl reduced hippocampal neuron apoptosis and oxidative stress induced by SEV anesthesia. These results suggest that LiCl may have potential for development into a therapeutic agent for treatment of SEV anesthesia‐induced cognitive dysfunction.

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mentioning

confidence: 99%

Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats

Wang

Zhang

et al. 2020

FEBS Open Bio

View full text Add to dashboard Cite

show abstract

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Assessing effect of anaesthetic methods on postoperative cognitive dysfunction

Cited by 1 publication

References 7 publications

Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats

Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats

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