Assessing environmental and occupational risk factors for lung cancer in Mexican–Americans

McHugh, Michelle K.; Kachroo, Sumesh; Liu, Mei; D’Amelio, Anthony M.; Dong, Qiong; Hong, Waun Ki; Greisinger, Anthony; Spitz, Margaret R.; Etzel, Carol J.

doi:10.1007/s10552-010-9635-1

Cited by 8 publications

(15 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have previously reported that the CBMN assay is a sensitive and specific predictor of lung cancer risk (34, 35) and we further found an increase in lung cancer risk for participants that self-reported exposure to asbestos, fiberglass, wood dust, solvents, bleach and pesticides(36) (37, 38). Based on these findings we conducted the current study to evaluate the extent of genetic instability (using the CBMN assay) in lung cancer cases and controls exposed to environmental agents (namely asbestos, fiberglass, wood dust, solvents, paints, exhaust, and bleach) and the effect of smoking on modulating such genetic instability.…”

Section: Introductionmentioning

confidence: 54%

Use of the Cytokinesis-Blocked Micronucleus Assay to Detect Gender Differences and Genetic Instability in a Lung Cancer Case–Control Study

McHugh

Lopez

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

Self Cite

View full text Add to dashboard Cite

Background: Although tobacco exposure is the predominant risk factor for lung cancer, other environmental agents are established lung carcinogens. Measuring the genotoxic effect of environmental exposures remains equivocal, as increases in morbidity and mortality may be attributed to coexposures such as smoking.Methods: We evaluated genetic instability and risk of lung cancer associated with exposure to environmental agents (e.g., exhaust) and smoking among 500 lung cancer cases and 500 controls using the cytokinesisblocked micronucleus (CBMN) assay. Linear regression was applied to estimate the adjusted means of the CBMN endpoints (micronuclei and nucleoplasmic bridges). Logistic regression analyses were used to estimate lung cancer risk and to control for potential confounding by age, gender, and smoking.Results: Cases showed significantly higher levels of micronuclei and nucleoplasmic bridges as compared with controls (mean AE SEM ¼ 3.54 AE 0.04 vs. 1.81 AE 0.04 and mean AE SEM ¼ 4.26 AE 0.03 vs. 0.99 AE 0.03, respectively; P < 0.001) with no differences among participants with or without reported environmental exposure. No differences were observed when stratified by smoking or environmental exposure among cases or controls. A difference in lung cancer risk was observed between nonexposed male and female heavy smokers, although it was not statistically significant (I 2 ¼ 64.9%; P value for Q statistic ¼ 0.09).

show abstract

Section: Introductionmentioning

confidence: 54%

Use of the Cytokinesis-Blocked Micronucleus Assay to Detect Gender Differences and Genetic Instability in a Lung Cancer Case–Control Study

McHugh

Lopez

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

Self Cite

View full text Add to dashboard Cite

show abstract

“…30 In our study, household income, another SES measure, was not associated with rates of ever-smoking for Hispanic men. greater exposure to occupational carcinogens among those with lower nSES 34 may also diminish the positive effect of nSES on lung cancer incidence, particularly among Hispanic men. Overall, the positive nSES gradient in NSCLC incidence seen among Hispanic men was based on relatively weaker and mixed associations.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Non–Small-Cell Lung Cancer among California Hispanics According to Neighborhood Socioeconomic Status

Wong

Clarke

Yang

et al. 2013

Journal of Thoracic Oncology

View full text Add to dashboard Cite

show abstract

“…It was shown that chloroform (2.9e24.6 mg m À3 ) and carbon tetrachloride (0.25e459 mg m À3 ) concentrations significantly increased during the use of bleach containing products corresponding to during/before concentration ratios of 8e52 (25 AE 14, average AE SD) for chloroform and 1e1170 (146 AE 367, average AE SD) for carbon tetrachloride, respectively (Odabasi, 2008). It was suggested that the bleach use can be important in terms of inhalation/dermal exposure to carbon tetrachloride, chloroform and several other halogenated VOCs (Bondi, 2011;McHugh et al, 2010;Odabasi, 2008). It was also shown that a substantial amount of chloroform is emitted into the indoor air as a result of chlorine bleach use in residential washing machines (Shepherd et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Halogenated volatile organic compounds in chlorine-bleach-containing household products and implications for their use

Odabaşı

Elbir

Dumanoğlu

et al. 2014

Atmospheric Environment

View full text Add to dashboard Cite

It was recently shown that substantial amounts of halogenated volatile organic compounds (VOCs) are formed in chlorine-bleach-containing household products as a result of reactions of sodium hypochlorite with organic product components. Use of these household products results in elevated indoor air halogenated VOC concentrations. Halogenated VOCs in several chlorine-bleach-containing household products (plain, n=9; fragranced, n=4; and surfactant-added, n=29) from Europe and North America were measured in the present study. Chloroform and carbon tetrachloride were the dominating compounds having average concentrations of 9.5±29.0 (average±SD) and 23.2±44.3 (average±SD) mgL-1, respectively. Halogenated VOC concentrations were the lowest in plain bleach, slightly higher in fragranced products and the highest in the surfactant-added products. Investigation of the relationship between the halogenated VOCs and several product ingredients indicated that chlorinated VOC formation is closely related to product composition. Indoor air concentrations from the household use of bleach products (i.e., bathroom, kitchen, and hallway cleaning) were estimated for the two dominating VOCs (chloroform and carbon tetrachloride). Estimated indoor concentrations ranged between 0.5 and 1030 (34±123, average±SD) μgm-3 and 0.3-1124 (82±194, average±SD) μgm-3 for chloroform and carbon tetrachloride, respectively, indicating substantial increases compared to background. Results indicated that indoor air concentrations from surfactant-added products were significantly higher (p<0.01) than other categories. The highest concentrations were from the use of surfactant-added bleach products for bathroom cleaning (92±228 and 224±334μgm-3, average±SD for chloroform and carbon tetrachloride, respectively). Associated carcinogenic risks from the use of these products were also estimated. The risk levels may reach to considerably high levels for a significant portion of the population especially for those steadily using the surfactant-added bleach products. Based on the results of the present study, it could be recommended that if possible the use of chlorine bleach containing household products should be avoided. If they are to be used, plain products should be preferred since the chlorinated VOC content increase with the number and amount of additives

show abstract

Assessing environmental and occupational risk factors for lung cancer in Mexican–Americans

Cited by 8 publications

References 46 publications

Use of the Cytokinesis-Blocked Micronucleus Assay to Detect Gender Differences and Genetic Instability in a Lung Cancer Case–Control Study

Use of the Cytokinesis-Blocked Micronucleus Assay to Detect Gender Differences and Genetic Instability in a Lung Cancer Case–Control Study

Incidence of Non–Small-Cell Lung Cancer among California Hispanics According to Neighborhood Socioeconomic Status

Halogenated volatile organic compounds in chlorine-bleach-containing household products and implications for their use

Contact Info

Product

Resources

About