Assessing Herb–Drug Interactions of Herbal Products With Therapeutic Agents for Metabolic Diseases: Analytical and Regulatory Perspectives

Satheeshkumar, N.; Paul, David; Bolla, Lavanya

doi:10.1016/b978-0-444-64179-3.00009-8

Cited by 14 publications

(8 citation statements)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GTE primarily consists of polyphenols, particularly (−)‐epigallocatechin‐3‐gallate, which constitutes about 50–60% of the total catechins. The constituents of GTE include flavonoids, xanthine alkaloids, saponins and tannins, as well as 300 additional substances (Nanjappan, Paul, & Bolla, ; Schonthal, ).…”

Section: Introductionmentioning

confidence: 99%

“…They also have antioxidant and anticarcinogenic, tyrosine kinase inhibition and antimetastatic effect, and modulate the cardio‐protective and immune systems. GTE have been shown to exhibit promising results against different types of carcinomas (Larsen, Dashwood, & Bisson, ; Namita, Mukesh, & Vijay, ; Nanjappan et al, ; Schonthal, ; Shih, Lin, Lin, Liu, & Kao, ; Shirakami, Shimizu, & Moriwaki, ). The beneficial effect of green tea or GTPs for weight loss or anti‐obesity is also popular globally (Yuan, Dong, Fang, Gong, & Lu, ).…”

Section: Introductionmentioning

confidence: 99%

“…Many documented potential HDI studies with GTE or GTP and anticancer drugs have been extrapolated from in vitro or in vivo studies (Ge et al, ; Golden et al, ; Maher et al, ; Qiao et al, ). HDI with GTE will influence the bioavailability and efficacy of target drugs, eventually leading to serious clinical consequences (Maher et al, ; Nanjappan et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…The constituents of GTE include flavonoids, xanthine alkaloids, saponins and tannins, as well as 300 additional substances (Nanjappan, Paul, & Bolla, 2019;Schonthal, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…A wide variety of putative therapeutic uses of GTP suggest the possibility for co-administration with allopathic medications and also enhance the chance of herb-drug interaction (HDI) or food-drug interactions (Bedrood, Rameshrad, & Hosseinzadeh, 2018;Nanjappan et al, 2019;Schonthal, 2011). GTE or GTP have already exhibited beneficial health effects and have been investigated as potential nutraceuticals for the treatment of cancer.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

An assessment of the impact of green tea extract on palbociclib pharmacokinetics using a validated UHPLC–QTOF–MS method

Paul

Surendran

Chandrakala

et al. 2019

Biomedical Chromatography

Self Cite

View full text Add to dashboard Cite

Green tea extracts (GTE) has been reported to be a kinase inhibitor and modulator for various drug metabolizing enzymes. It may give synergetic antioncogenic effect, but with a possibility of pharmacokinetic interactions with various co‐administered anticancer agents like palbociclib (PAL), a selective inhibitor of CDK‐4/6 primarily metabolized by CYP3A enzyme. To explore the impact of GTE on PAL pharmacokinetics in Sprague–Dawley rats, a rapid and sensitive UHPLC–QTOF–MS method was established. Chromatographic separation was carried out on an Acquity UPLC BEH C18 (100 × 2.1 mm, 1.7 μm) column using a gradient mobile phase system consisting of 0.1% formic acid and acetonitrile. Sample preparation was based on a simple protein precipitation method. Estimation of target ions [M + H]+ at m/z 448.2455 for PAL and m/z 441.2044 for ibrutinib (IS) was performed in selective ion mode ESI–HRMS. Good sensitivity (1.0 ng/mL) and linearity over a wide concentration range of 1–2000 ng/mL was exhibited by the method. The results indicated that the administration of GTE resulted in decreased oral bioavailability of PAL in both short‐ and long‐term conditions. However, when both conditions were compared, the variation was less for the peak concentration and area under the concentration–time curve level of PAL.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The constituents of GTE include flavonoids, xanthine alkaloids, saponins and tannins, as well as 300 additional substances (Nanjappan, Paul, & Bolla, 2019;Schonthal, 2011).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations