Assessing Liver Function in Liver Tumors Patients: The Performance of T1 Mapping and Residual Liver Volume on Gd-EOBDTPA-Enhanced MRI

Duan, Ting; Jiang, Hanyu; Xia, Chunchao; Chen, Jie; Cao, Likunn; Zheng, Yi; Yi, Wei; Song, Bin; Lee, Jeong Min

doi:10.3389/fmed.2020.00215

Cited by 8 publications

(9 citation statements)

References 32 publications

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“…Regrettably, that study did not consider the different sizes of different liver segments. However, several studies have demonstrated that liver volume-adjusted rrT1 values correlated better with ICG-PDR ( 65 ) and ICG-R15 ( 67 ) than the rrT1 values alone. In addition, Yoon et al indicated that the combined value of T1 and liver volume, adjusted for patient weight, could serve to identify patients with CP-A cirrhosis at high risk of decompensation ( 81 ).…”

Section: Recent Approaches To Liver Function Measurement Using Contra...mentioning

confidence: 99%

“…In patients scheduled for hepatectomy, to avoid PHLF, it is necessary to assess the precise liver function of the remnant liver, especially in those with liver diseases ( 82 ). By combining rrT1 with the remnant liver volume, good diagnostic accuracy was obtained ( 67 ). Additionally, Huang et al showed the importance of the rrT1 value of the liver remnant, where the rrT1 value of the remnant was an independent risk factor for major postoperative complications ( 83 ); specifically, in patients who have undergone a major partial hepatectomy, the lower the rrT1 value, the higher the risk of a postoperative complication was.…”

Section: Recent Approaches To Liver Function Measurement Using Contra...mentioning

confidence: 99%

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Assessment of Liver Function With MRI: Where Do We Stand?

et al. 2022

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Liver disease and hepatocellular carcinoma (HCC) have become a global health burden. For this reason, the determination of liver function plays a central role in the monitoring of patients with chronic liver disease or HCC. Furthermore, assessment of liver function is important, e.g., before surgery to prevent liver failure after hepatectomy or to monitor the course of treatment. Liver function and disease severity are usually assessed clinically based on clinical symptoms, biopsy, and blood parameters. These are rather static tests that reflect the current state of the liver without considering changes in liver function. With the development of liver-specific contrast agents for MRI, noninvasive dynamic determination of liver function based on signal intensity or using T1 relaxometry has become possible. The advantage of this imaging modality is that it provides additional information about the vascular structure, anatomy, and heterogeneous distribution of liver function. In this review, we summarized and discussed the results published in recent years on this technique. Indeed, recent data show that the T1 reduction rate seems to be the most appropriate value for determining liver function by MRI. Furthermore, attention has been paid to the development of automated tools for image analysis in order to uncover the steps necessary to obtain a complete process flow from image segmentation to image registration to image analysis. In conclusion, the published data show that liver function values obtained from contrast-enhanced MRI images correlate significantly with the global liver function parameters, making it possible to obtain both functional and anatomic information with a single modality.

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Section: Recent Approaches To Liver Function Measurement Using Contra...mentioning

confidence: 99%

Section: Recent Approaches To Liver Function Measurement Using Contra...mentioning

confidence: 99%

Assessment of Liver Function With MRI: Where Do We Stand?

et al. 2022

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“…The results of our study have revealed that the estimation liver function using MRI corelates with the MELD-Na score and there is statistically significant difference between the MRI estimated liver function of normal and cirrhotic livers. Any chronic insult to the liver parenchyma may result in hepatocellular injury that later leads to development of fibrosis, with continued progression resulting in cirrhosis and consequently hepatic synthetic function impairment [8]. There are several scoring systems for the clinical estimation of hepatic synthetic function in cirrhotic patients.…”

Section: Discussionmentioning

confidence: 99%

“…The anatomical detail of MRI also enables one step examination of focal liver lesions, surgical planning and liver function [6]. The double dose approach has been proposed for the use of hepatobiliary contrast agent Gadoxetic acid to achieve an improved T1 relaxation time shortening for the assessment of HCC in cirrhotic patients [8]. The aim of this study is to retrospectively evaluate the role of Gadoxetic acid in the estimation of liver function and correlate this with MELD Na scores in patients with liver cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

MRI Estimation of Liver Function: Comparison Between Normals and Cirrhotic Patients with Different MELD-Na Scores

Balci¹,

Kumar²,

John³

et al. 2021

Med Imaging Radiol

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Purpose: Currently used prognostic models in cirrhosis rely on clinical and laboratory criteria. Quantitative MRI estimation of liver function could determine degree of hepatic synthetic function impairment and could consequently be used as a prognostic tool in patients with cirrhosis. Our aim was to estimate liver function using MRI and assess its correlation with MELD-Na score, an established laboratory-based prognostic model in cirrhosis. Methods: 52 subjects without liver disease (controls) and 79 patients with cirrhosis were retrospectively evaluated. Patients with cirrhosis were stratified based on MELD-Na scores into the following groups: 6-10, 11-17, 18-24 and 25-40. All subjects underwent MRI with hepatobiliary contrast agent Gadoxetic acid (Gd-EOB) and T1 relaxation time map of all subjects were created for pre and postcontrast images. The T1 time ratio between pre-and postcontrast hepatobiliary phase images were determined in all study subjects and correlated with MELD-Na scores in patients with cirrhosis. Results: The average T1 ratio in healthy controls was 0.83. The average T1 ratios in patients with MELD-Na scores of 6-10, 11-17, 18-24 and 25-40 were 0.79, 0.69, 0.58 and 0.50 respectively. There was significant difference between T1 ratios in controls without liver disease and patients with cirrhosis (p<0.001). Moreover, T1 ratios among patients with cirrhosis increased with each successive range of MELD-Na scores (p<0.001). Conclusion:The T1 map MR estimation of liver function with the use of hepatobiliary contrast agent correlates well with established prognostic models in cirrhosis and could be a valuable adjunct to currently available clinical tools to estimate liver function and thereby enable prognostication in patients with cirrhosis.

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“…Yoon et al [ 109 ] reported that T1 mapping on gadoxetate-enhanced MRI provided information on global liver function and demonstrated functional heterogeneity in patients with HCC. Other studies have combined liver volume with hepatocyte function, and their results showed that combined T1 mapping and residual liver volume on gadoxetate-enhanced MRI could assess liver function with good diagnostic accuracy in patients with liver tumors[ 110 - 112 ]. Kim et al [ 113 ] and Wang et al [ 114 ] reported that the combination could predict post hepatectomy liver failure better than the ICG clearance test in patients with HCC who underwent hepatectomy.…”

Section: Focal Liver Lesionsmentioning

confidence: 99%

Noninvasive imaging of hepatic dysfunction: A state-of-the-art review

Duan¹,

Jiang²,

Ling³

et al. 2022

WJG

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Hepatic dysfunction represents a wide spectrum of pathological changes, which can be frequently found in hepatitis, cholestasis, metabolic diseases, and focal liver lesions. As hepatic dysfunction is often clinically silent until advanced stages, there remains an unmet need to identify affected patients at early stages to enable individualized intervention which can improve prognosis. Passive liver function tests include biochemical parameters and clinical grading systems ( e.g ., the Child-Pugh score and Model for End-Stage Liver Disease score). Despite widely used and readily available, these approaches provide indirect and limited information regarding hepatic function. Dynamic quantitative tests of liver function are based on clearance capacity tests such as the indocyanine green (ICG) clearance test. However, controversial results have been reported for the ICG clearance test in relation with clinical outcome and the accuracy is easily affected by various factors. Imaging techniques, including ultrasound, computed tomography, and magnetic resonance imaging, allow morphological and functional assessment of the entire hepatobiliary system, hence demonstrating great potential in evaluating hepatic dysfunction noninvasively. In this article, we provide a state-of-the-art summary of noninvasive imaging modalities for hepatic dysfunction assessment along the pathophysiological track, with special emphasis on the imaging modality comparison and selection for each clinical scenario.

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Assessing Liver Function in Liver Tumors Patients: The Performance of T1 Mapping and Residual Liver Volume on Gd-EOBDTPA-Enhanced MRI

Cited by 8 publications

References 32 publications

Assessment of Liver Function With MRI: Where Do We Stand?

Assessment of Liver Function With MRI: Where Do We Stand?

MRI Estimation of Liver Function: Comparison Between Normals and Cirrhotic Patients with Different MELD-Na Scores

Noninvasive imaging of hepatic dysfunction: A state-of-the-art review

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