Assessing low levels of high-density lipoprotein cholesterol as a risk factor in coronary heart disease

Gotto, Antonio M.; Brinton, Eliot A.

doi:10.1016/j.jacc.2003.08.061

Cited by 199 publications

(87 citation statements)

References 80 publications

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“…The Expert Group on HDL recommends considering the addition of a fibrate or niacin for persons whose HDL cholesterol level is less than 40 mg/dl and who have diabetes. 19 In the postoperative period, five (6.9%) patients still had low levels of HDL and HbA1c above 6%, so lifestyle modifications, followed by the consideration of pharmacotherapy in these high-risk patients, were suggested.…”

Section: Discussionmentioning

confidence: 99%

Impact on Dyslipidemia of the Laparoscopic Ileal Interposition Associated to Sleeve Gastrectomy in Type 2 Diabetic Patients

DePaula¹,

Stival²,

DePaula

et al. 2010

Journal of Gastrointestinal Surgery

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Section: Discussionmentioning

confidence: 99%

Impact on Dyslipidemia of the Laparoscopic Ileal Interposition Associated to Sleeve Gastrectomy in Type 2 Diabetic Patients

DePaula¹,

Stival²,

DePaula

et al. 2010

Journal of Gastrointestinal Surgery

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“…in particular, low hdL cholesterol and high TG levels are the most prominent predictors of cardiovascular disease [15]. Plasma TG levels also positively correlate with the plasma hdL cholesterol level [23].…”

Section: Energy Metabolismmentioning

confidence: 99%

“…Plasma TG levels also positively correlate with the plasma hdL cholesterol level [23]. To date, many QTLs affecting plasma lipid levels have been detected in humans and in mice [15,42,62]. in mice, more than 100 QTLs have been reported on all autosomes based on the results of 23 different genetic crosses including the B6 strain and the wild mouse-derived strains CaSa, CaST, PEra, and SPrET [42].…”

Section: Energy Metabolismmentioning

confidence: 99%

Complex Quantitative Traits Cracked by the Mouse Inter-Subspecific Consomic Strains

Takada

Shiroishi

2012

Exp. Anim.

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Mammalian quantitative traits that are observed at the whole-body level, such as body weight and length and blood biochemical parameters, are determined by the cooperative effects of multiple genetic and epigenetic factors as well as environmental factors. This complexity has hampered the genetic analysis of quantitative traits. To overcome this difficulty, we have established a full set of consomic mouse strains, also known as chromosome substitution strains, by replacing every chromosome of the classical inbred strain C57BL/6J with its counterpart from the Japanese wildmouse-derived inbred strain MSM/Ms. The core components of the genomes of these two strains originated from different mouse subspecies. The inter-subspecific large-genome divergence and phenotypic differences between the two strains allowed the identification of genetic determinants for many quantitative traits by comprehensive phenotype screening. For some quantitative traits, the genetic determinants could be dissected into multiple chromosomes, thereby reflecting strain differences between C57BL/6J and MSM/Ms and their simple additive effects on the background of the consomic host strain. For other quantitative traits, the measured values of some consomic strains often far exceeded the range of the two parental strains, which suggests that nonadditive genetic interactions occur among multiple genes located on the substituted MSM/Ms chromosomes and the consomic host chromosomes. Thus, the inter-subspecific consomic strains are unique tools that can be used to identify both additive and nonadditive genetic effects on quantitative complex traits.

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“…Much of the anti-atherogenic effect of HDL is thought to be mediated by reverse cholesterol transport, a process whereby excess cholesterol in cells and in atherosclerotic plaques is removed [112]. Initially hepatic and intestinal cells synthesise small nascent HDL particles composed of phospholipids and apolipoproteins [113].…”

Section: Effects Of Dyslipidaemia In Cvdmentioning

confidence: 99%

Cardiovascular disease in rheumatoid arthritis

Pahau¹

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This thesis focuses on cardiovascular (CV) disease (CVD) risk in rheumatoid arthritis (RA). Inflammation and CV risk factors are increased in RA patients. This population has a higher carotid intima-media thickness and more CV events than the general population and kynurenine (KYN) concentration levels are higher in RA patients compared to healthy controls. Therefore, in this thesis inflammation and CVD risk factors are investigated for increased risk of future RA development. RA and type2 diabetes (T2D) carotid intima-media thickness (CIMT) are compared and measurements of serum KYN for CVD, cancer and mortality are studied. First I tested the hypothesis that inflammation, CVD and CV risk factors are associated with increased risk of future RA development. Data from the Norwegian HUNT population health survey were obtained to compare groups with RA at baseline and follow-up (HUNT2 and HUNT3, n = 429) or follow up alone (HUNT3, n = 786), or without RA at both times (n = 33,567). Results showed female gender, age, smoking, body mass index (BMI), and history of previous CVD were associated with self-reported incident RA (previous CVD: odds ratio 1.52 (95% confidence interval 1.11-2.07). The findings regarding previous CVD were confirmed in sensitivity analyses excluding participants with psoriasis (odds ratio (OR) 1.70 (1.232.36)) or restricting the analysis to cases with hospital diagnosis of RA (OR 1.90 (1.10-3.27)) or carriers of the shared epitope (OR 1.76 (1.134-2.74)). History of previous CVD was not associated with increased risk of osteoarthritis (OR 1.04 (0.86-1.27)). I then compared the characteristics of CV risk and progression of CIMT in 78 RA patients from an outpatient Rheumatology Clinic and 212 patients with T2D who attended a community or hospital diabetes clinic in Brisbane. We found that the burden of risk varied between the 2 cohorts.RA patients were older, had a higher proportion of smokers, females and previous CVD. T2D patients had a higher body mass index (BMI), diastolic blood pressure, triglycerides, lower high density lipoprotein and a higher statin use. At baseline, CIMT measurements were similar in the RA and T2D cohorts. In an adjusted linear regression model, RA was significantly associated with lower CIMT at follow-up. Despite a shorter follow-up, 91 % ii of the T2D cohort had increased CIMT at follow-up compared to 54 % of the RA cohort. In the RA cohort, disease modifying anti-rheumatic drug (DMARD) use at baseline was associated with significantly lower CIMT values at follow-up.Finally we hypothesized that increased KYN in RA patients may predispose to CVD, infections and cancer. We measured KYN in 129 RA patients followed for 10 years for development of CVD, cancer and death. Median KYN concentrations were significantly higher in RA patients than in controls, but there was large overlap between groups. There were no variables in our data set that could explain the differences in KYN Outcome of an intensive treat-to-target disease modifying drug regimen in early rheuma...

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Assessing low levels of high-density lipoprotein cholesterol as a risk factor in coronary heart disease

Cited by 199 publications

References 80 publications

Impact on Dyslipidemia of the Laparoscopic Ileal Interposition Associated to Sleeve Gastrectomy in Type 2 Diabetic Patients

Impact on Dyslipidemia of the Laparoscopic Ileal Interposition Associated to Sleeve Gastrectomy in Type 2 Diabetic Patients

Complex Quantitative Traits Cracked by the Mouse Inter-Subspecific Consomic Strains

Cardiovascular disease in rheumatoid arthritis

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