Assessing Particle Segregation Using Near-Infrared Chemical Imaging in Twin Screw Granulation

Mundozah, Aquino L.; Yang, Jiankai; Tridon, Claire C.; Cartwright, J.; Omar, Chalak S.; Salman, Agba D.

doi:10.1016/j.ijpharm.2019.118541

Cited by 15 publications

(15 citation statements)

References 25 publications

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“…This is attributed to the increase in powder throughput force with an increase in feed rate, and this decreases the occurrence of back mixing and eventually leads to an increase in axial velocity and decrease in MRT. Mundozah et al [ 51 ] and Meier et al [ 36 ] showed that even though there is a decrease in MRT with an increase in feed rate, the increase in the holdup and fill level prevailed. This can be attributed to the nature of the effect feed rate has on MRT and holdup, which are also dependent on other factors such as screw speed and screw configuration [ 50 ], which decreases the influence of feed rate on MRT.…”

Section: Resultsmentioning

confidence: 99%

“…In twin-screw granulation, the binder liquid is generally added by a dripping mechanism due to the design of the equipment. In such as system, the nucleation mechanism is controlled by its kinetic parameters such as drop penetration time and the spreading of the liquid droplet over the solid powder [ 51 , 54 , 55 ]. The drop penetration time decreases with an increase in binder viscosity, the spreading of the drop on the powder surface also decreases [ 19 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

“…In such as system, the nucleation mechanism is controlled by its kinetic parameters such as drop penetration time and the spreading of the liquid droplet over the solid powder [ 51 , 54 , 55 ]. The drop penetration time decreases with an increase in binder viscosity, the spreading of the drop on the powder surface also decreases [ 19 , 51 ]. This leads to an increase in the available surface liquid on the granule, leading to the formation of strong and dense granules [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Development of a Granule Growth Regime Map for Twin Screw Wet Granulation Process via Data Imputation Techniques

2022

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Twin screw granulation (TSG) is a continuous wet granulation technique that is used widely across different solid manufacturing industries. The TSG has been recognized to have numerous advantages due to its modular design and continuous manufacturing capabilities, including processing a wide range of formulations. However, it is still not widely employed at the commercial scale because of the lack of holistic understanding of the process. This study addresses that problem via. the mechanistic development of a regime map that considers the complex interactions between process, material, and design parameters, which together affect the final granule quality. The advantage of this regime map is that it describes a more widely applicable quantitative technique that can predict the granule growth behavior in a TSG. To develop a robust regime map, a database of various input parameters along with the resultant final granule quality attributes was created using previously published literature experiments. Missing data for several quality attributes was imputed using various data completion techniques while maintaining physical significance. Mechanistically relevant non-dimensional X and Y axis that quantify the physical phenomena occurring during the granulation were developed to improve the applicability and predictability of the regime map. The developed regime map was studied based on process outcomes and granule quality attributes to identify and create regime boundaries for different granule growth regimes. In doing so breakage-dominant growth was incorporated into the regime map, which is very important for TSG. The developed regime map was able to accurately explain the granule growth regimes for more than 90% of the studied experimental points. These experimental were generated at vastly different material, design, and process parameters across various studies in the literature, this further increases the confidence in the developed regime map.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Development of a Granule Growth Regime Map for Twin Screw Wet Granulation Process via Data Imputation Techniques

2022

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“…On the other hand, in further barrel sections, the component distribution underwent changes due to particle collisions, abrasion and chipping, and at the final stage the granules regained their homogeneity owing to competing breakage and consolidation mechanisms. In summary, the authors proposed to map demixing potential as a function of a dimensionless mixing number, which is described by mean residence time, torque and the free volume of the twin-screw granulator [88].…”

Section: Examples Of Granulated Blendsmentioning

confidence: 99%

Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity—A Review

Jakubowska

Ciepluch

2021

Pharmaceutics

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Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted uniformity in the final product may be caused either by suboptimal mixing and insufficient initial blend homogeneity, or may result from further particle segregation during storage, transfer or the compression process itself. This review presents the most relevant powder segregation mechanisms in tablet manufacturing and summarizes the currently available, up-to-date research on segregation and uniformity loss at the various stages of production process—the blend transfer from the bulk container to the tablet press, filling and discharge from the feeding hopper, as well as die filling. Formulation and processing factors affecting the occurrence of segregation and tablets’ CU are reviewed and recommendations for minimizing the risk of content uniformity failure in tablets are considered herein, including the perspective of continuous manufacturing.

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“…In addition, the multivariate modeling technique has been widely used to predict or detect CQAs or API contents in the twin screw granulation process. 182–186 …”

Section: Application Of Multivariate Modeling Techniques In Tablet Ma...mentioning

confidence: 99%

Pharmaceutical application of multivariate modelling techniques: a review on the manufacturing of tablets

et al. 2021

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Assessing Particle Segregation Using Near-Infrared Chemical Imaging in Twin Screw Granulation

Cited by 15 publications

References 25 publications

Development of a Granule Growth Regime Map for Twin Screw Wet Granulation Process via Data Imputation Techniques

Development of a Granule Growth Regime Map for Twin Screw Wet Granulation Process via Data Imputation Techniques

Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity—A Review

Pharmaceutical application of multivariate modelling techniques: a review on the manufacturing of tablets

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