Assessing pharmaceutical removal and reduction in toxicity provided by advanced wastewater treatment systems

Angeles, Luisa F.; Mullen, Rachel A.; Huang, Irvin J.; Wilson, Christopher; Khunjar, Wendell; Sirotkin, Howard I.; McElroy, Anne E.; Aga, Diana S.

doi:10.1039/c9ew00559e

Cited by 99 publications

(68 citation statements)

References 59 publications

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“…Recognition of the expanding extent of PPCP contamination has stimulated the search for solutions that remove pharmaceuticals from wastewater before they can reach the environment, including technologies like advanced oxidation processes and membrane bioreactors 58-62 . These new technologies have shown promise with higher removal rates in pilot treatment plants than with conventional treatment 61,63 . In combination with increased removal efficiencies, re-designing PPCPs to promote biodegradability could lead to a reduction in the environmental load in the future 64,65 .…”

Section: Future Directions For Ppcp Removalmentioning

confidence: 99%

Microbial transformation of widely used pharmaceutical and personal care product compounds

et al. 2020

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F1000 Faculty Reviews are written by members of the prestigious . They are F1000 Faculty commissioned and are peer reviewed before publication to ensure that the final, published version is comprehensive and accessible. The reviewers who approved the final version are listed with their names and affiliations. AbstractPharmaceutical and personal care products (PPCPs) are commonly used chemicals that are increasingly detected in urban-impacted environments, particularly those receiving treated wastewater. PPCPs may have toxicological effects on the macrofauna that are exposed through contaminated water; thus, there is interest in microbially mediated transformations that may degrade PPCPs. This review discusses specific examples of PPCP transformations that may occur in anoxic environments, including O-methylation and O-demethylation. PubMed Abstract | Publisher Full Text | Free Full Text | F1000 Recommendation 2. Kolpin DW, Furlong ET, Meyer MT, et al.: Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ Sci Technol. 2002; 36(6): 1202-11. PubMed Abstract | Publisher Full Text 3. Xia K, Bhandari A, Das K, et al.: Occurrence and fate of pharmaceuticals and personal care products (PPCPs) in biosolids. J Environ Qual. 2005; 34(1): 91-104. PubMed Abstract | Publisher Full Text 4. Jelic A, Rodriguez-Mozaz S, Barceló D, et al.: Impact of in-sewer transformation on 43 pharmaceuticals in a pressurized sewer under anaerobic conditions. Water Res. 2015; 68: 98-108. PubMed Abstract | Publisher Full Text 5. Fick J, Söderström H, Lindberg RH, et al.: Contamination of surface, ground, and drinking water from pharmaceutical production. Environ Toxicol Chem. 2009; 28(12): 2522-7. PubMed Abstract | Publisher Full Text 6. Biel-Maeso M, Corada-Fernández C, Lara-Martín PA: Removal of personal care products (PCPs) in wastewater and sludge treatment and their occurrence in receiving soils. Water Res. 2019; 150: 129-39. PubMed Abstract | Publisher Full Text | F1000 Recommendation 7. Kinney CA, Furlong ET, Zaugg SD, et al.: Survey of organic wastewater contaminants in biosolids destined for land application. Environ Sci Technol. 2006; 40(23): 7207-15. PubMed Abstract | Publisher Full Text 8. Sabourin L, Beck A, Duenk PW, et al.: Runoff of pharmaceuticals and personal care products following application of dewatered municipal biosolids to an agricultural field. Sci Total Environ. 2009; 407(16): 4596-604. PubMed Abstract | Publisher Full Text 9. Watanabe H, Tamura I, Abe R, et al.: Chronic toxicity of an environmentally relevant mixture of pharmaceuticals to three aquatic organisms (alga, daphnid, and fish). Environ Toxicol Chem. 2016; 35(4): 996-1006. PubMed Abstract | Publisher Full Text 10. Bringolf RB, Heltsley RM, Newton TJ, et al.: Environmental occurrence and reproductive effects of the pharmaceutical fluoxetine in native freshwater mussels. Environ Toxicol Chem. 2010; 29(6): 1311-8. PubMed Abstract | Publisher Full Text 11. Dzieweczynski TL, Campbell BA,...

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Section: Future Directions For Ppcp Removalmentioning

confidence: 99%

Microbial transformation of widely used pharmaceutical and personal care product compounds

et al. 2020

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“…The intensive use of paracetamol leads to its presence in the environment, and more specifically in the surrounding waters. This makes a real problem for humans and other living things, since paracetamol breaks down into very toxic metabolites [5][6][7][8]. A general awareness is therefore necessary in order to propose effective methods for detection, quantification and decontaminating wastewaters containing paracetamol.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical oxidation and electroanalysis of paracetamol on a boron-doped diamond anode material in aqueous electrolytes

Kouadio

Ollo²,

Koffi

et al. 2021

J. Electrochem. Sci. Eng.

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Electrochemical oxidation of paracetamol on boron-doped diamond (BDD) anode has been studied by cyclic voltammetry and preparative electrolysis. Quantification of paracetamol during electrolysis has been mainly realized by differential pulse voltammetry technique in the Britton-Robinson buffer solutions used as the supporting electrolyte. Various parameters such as current intensity, nature of the supporting electrolyte, temperature, and initial concentration of paracetamol have been investigated. The electrochemical characterization by the outer sphere Fe(III)/Fe(II) redox couple has also been performed, showing the metallic character of BDD electrode. The obtained linear dependency of the oxidation peak current intensity and paracetamol concentration indicates that BDD electrode can be used as an electrochemical sensor for the detection and quantification of paracetamol. The investigation of paracetamol degradation during preparative electrolysis showed that: (i) the degradation rate of paracetamol increases with increase of current intensity applied; (ii) for the initial concentrations of 10, 6 and 1 mM of paracetamol, its oxidation rate reaches 60, 78 and 99 % respectively, after 1 h of electrolysis in 0.3 M H2SO4 (pH 0.6) at applied current density of 70 mA cm-2; (iii) at temperatures of electrolyte solution of 28, 55 and 75 °C, paracetamol oxidation rate reached 85, 92 and 97 % respectively, after 2 h at applied current density of 70 mA cm2. From the investigation of the effect of pH value of electrolyte solution, it appears that oxidation of paracetamol is more favorable in acidic solution at pH 3 than solutions of higher pH values.

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“…The latter are introduced into the environment through anthropogenic activities: industrial discharges, animal manure, wastewater from various treatments, waste and unused drugs caused by runoff from landfills household waste or waste water [3][4][5]. Recent studies claim that hospital wastewater is the pharmaceuticals main source in the aquatic environment [3,6,7]. These substances come essentially from human consumption (prescription in pharmacies, hospital uses) and / or animal (veterinary treatments).…”

Section: Introductionmentioning

confidence: 99%

Electrooxidation of the Paracetamol on Boron Doped Diamond Anode Modified by Gold Particles

Ollo¹,

Pacome

Guillaume

et al. 2021

IRJPAC

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The environment pollution, in particular that of the aquatic environment, by wastewater is a reality because it is discharged for the most part without treatment. The presence of pharmaceutical pollutants such as paracetamol in these waters can constitute a risk to human health. The objective of this work is to study the electrochemical oxidation of paracetamol using cyclic voltammetry on the boron doped diamond (BDD) anode and boron doped diamond modified by gold particles (Au-BDD) anode. The Au-BDD electrode was obtained by modifying the surface of BDD with gold particles. This was done by electrodeposition (chronoamperometry) in 0.5 M HAuCl4 and 0.1 M H2SO4 using a three pulse nucleation and growth process. Physical characterization with Scanning Electron Microscopy coupled with Dispersive Energy spectroscopy has shown that the Au-BDD surface presents asperities with the presence of microparticles and nanoparticles. The electrochemical characterization made in three electrolytic solutions (H2SO4, NaOH and KClO4) showed that Au-BDD has a high electroactivity domain than that of BDD. The study of the Benzoquinone-hydroquinone redox couple has shown a quasi-reversible character of these two anodes. It also revealed that Au-BDD has a more accentuated metallic character than BDD. The voltammetric measurements made it possible to show that the paracetamol oxidation is limited by the transport of material on each anode. This oxidation is characterized by the presence of an anodic peak in the support electrolytes stability domain. The paracetamol oxidation is rapid on Au-BDD than on BDD in the various medium explored, thus showing that Au-BDD is more efficient than BDD for the paracetamol oxidation by electrochemical means.

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Assessing pharmaceutical removal and reduction in toxicity provided by advanced wastewater treatment systems

Abstract: Despite large differences in removal efficiencies, all treatment processes investigated were sufficient in preventing short-term behavioral effects in zebrafish larvae.

Cited by 99 publications

References 59 publications

Microbial transformation of widely used pharmaceutical and personal care product compounds

Microbial transformation of widely used pharmaceutical and personal care product compounds

Electrochemical oxidation and electroanalysis of paracetamol on a boron-doped diamond anode material in aqueous electrolytes

Electrooxidation of the Paracetamol on Boron Doped Diamond Anode Modified by Gold Particles

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