The ongoing global warming and changing patterns of precipitation have significant implications for crop yields. Process-based models are the most commonly used method to assess the impacts of projected climate changes on crop yields. In this study, the crop-environment resource synthesis (CERES)-Maize 4.6.7 model was used to project the maize crop yield in the Shaanxi Province of China over future periods. In this context, the downscaled ensemble projections of 17 general circulation models (GCMs) under four representative concentration pathways (RCP 2.6, RCP 4.5, RCP 6.0, and RCP 8.5) were used as input for the calibrated CERES-Maize model. Results showed a negative correlation between temperature and maize yield in the study area. It is expected that each 1.0 °C rise in seasonal temperature will cause up to a 9% decrease in the yield. However, the influence of CO2 fertilization showed a positive response, as witnessed by the increase in the crop yield. With CO2 fertilization, the average increase in the maize crop yield compared to without CO2 fertilization per three decades was 10.5%, 11.6%, TA7.8%, and 6.5% under the RCP2.6, RCP4.5, RCP6.0, and RCP8.5 scenarios, respectively. An elevated CO2 concentration showed a pronounced positive impact on the rain-fed maize yield compared to the irrigated maize yield. The average water use efficiency (WUE) was better at elevated CO2 concentrations and improved by 7â21% relative to the without CO2 fertilization of the WUE. Therefore, future climate changes with elevated CO2 are expected to be favorable for maize yields in the Shaanxi Province of China, and farmers can expect further benefits in the future from growing maize.