Combined sewer overflows (CSOs) prevent surges in sewer networks by releasing untreated wastewater into nearby water bodies during intense storm events. CSOs can have acute and detrimental impacts on the environment and thus need to be managed. Although several gray, green and hybrid CSO mitigation measures have been studied, the influence of network structure on CSO occurrence is not yet systematically evaluated. This study focuses on evaluating how the variation of urban drainage network structure affects the frequency and magnitude of CSO events. As a study case, a sewer subnetwork in Dresden, Germany, where 11 CSOs are present, was selected. Scenarios corresponding to the structures with the lowest and with the highest number of possible connected pipes, are developed and evaluated using long-term hydrodynamic simulation. Results indicate that more meshed structures are associated to a decrease on the occurrence and magnitude of CSO. Event frequency reductions vary between 0% and 68%, while reduction of annual mean volumes and annual mean loads ranged between 0% and 87% and 0% and 92%. These rates were mainly related to the additional sewer storage capacity provided in the more meshed scenarios, following a sigmoidal behavior. However, increasing network connections causes investment costs, therefore optimization strategies for selecting intervention areas are needed. Furthermore, the present approach of reducing CSO frequency may provide a new gray solution that can be integrated in the development of hybrid mitigation strategies for the CSO management.