Assessing the Anti-Inflammatory Effects of an Orally Dosed Enzymatically Liberated Fish Oil in a House Dust Model of Allergic Asthma

Currie, Crawford; Framroze, Bomi; Singh, Dave; Lea, Simon; Bjerknes, Christian; Hermansen, Erland

doi:10.3390/biomedicines10102574

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…Further, this cytokine result looks to fit with prior research indicating that fish oil helps the body resolve inflammation rather than suppressing it [21]. Previous research with the OmeGo has demonstrated the reduction of inflammatory mediators associated with type 2 inflammation [16][17][18]. This would be expected to moderate the initial inflammatory response to carrageenan-induced inflammation.…”

Section: Discussionsupporting

confidence: 80%

“…OmeGo is an enzymatically liberated salmon oil which contains all 21 omegas and fatty acids present in the oil fraction of whole fish. Our previous work has shown OmeGo to have antioxidant and anti-inflammatory properties enabling the reduction in oxidised LDL in healthy human subjects and the attenuation of allergic inflammation in preclinical models [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Cathepsin K Inhibitor & Atorvastatin in Protection Against Atherosclerosis in High Fat Diet-Fed Rats

Omar

Abdelmenem²,

Malek³

et al. 2020

BJSTR

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Bjerknes and Bomi Framroze. Preliminary Insights into the Inflammation-Resolving Effect of OmeGo, An Enzymatically Liberated Fish Oil, Compared to Diclofenac in A Rat Paw Edema Injection Model. Biomed J Sci & Tech Res 47(1)-2022. BJSTR. MS.ID.007452.Whilst inflammation is a natural response to injury and wear and tear on the body the associated pain and swelling are clearly problematic for the sufferer. Marin polyunsaturated fatty acids, including omega-3, are known to have inflammation-resolving effects and our previous work has shown the minimally processed whole fish oil, OmeGo, to significantly reduce type 2, allergic inflammation. As a next step, this preliminary study used a standard carrageenan-induced rat paw swelling model of (type 1) acute inflammation to assess whether OmeGo could alleviate the paw swelling. Over the 24-hour period of the study, OmeGo showed a similar impact on paw swelling as active control, the non-steroidal anti-inflammatory drug, diclofenac. Diclofenac also markedly reduced the inflammatory cytokines IL-1 and IL-6 whereas OmeGo did not. This suggests that OmeGo's effects occur through different pathways compared to NSIAD therapy. Further work is planned to further characterise OmeGo's modulation of inflammatory pathways and its potential as a pragmatic approach to help resolve acute inflammation.the resulting inflammation compared to diclofenac.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Role of Cathepsin K Inhibitor & Atorvastatin in Protection Against Atherosclerosis in High Fat Diet-Fed Rats

Omar

Abdelmenem²,

Malek³

et al. 2020

BJSTR

View full text Add to dashboard Cite

show abstract

“…Beyond the anti-inflammatory effects of oleic acid and pentadecanoic acid noted above, OmeGo also contains a lipopeptide fraction composed of microcolins. These originate from blue-green algae, a natural part of the fish's diet, and have been shown to moderate type 2 eosinophilic inflammation, including a reduction in eosinophilic activation and migration and associated reductions in IL-13 levels [20,67,68].…”

Section: Discussionmentioning

confidence: 99%

Assessing the Potential of an Enzymatically Liberated Salmon Oil to Support Immune Health Recovery from Acute SARS-CoV-2 Infection via Change in the Expression of Cytokine, Chemokine and Interferon-Related Genes

Currie,

Myklebust,

Bjerknes

et al. 2024

IJMS

Self Cite

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Cytokines, chemokines, and interferons are released in response to viral infection with the ultimate aim of viral clearance. However, in SARS-CoV-2 infection, there is an imbalanced immune response, with raised cytokine levels but only a limited interferon response with inefficient viral clearance. Furthermore, the inflammatory response can be exaggerated, which risks both acute and chronic sequelae. Several observational studies have suggested a reduced risk of progression to severe COVID-19 in subjects with a higher omega-3 index. However, randomized studies of omega-3 supplementation have failed to replicate this benefit. Omega-3 fats provide important anti-inflammatory effects; however, fatty fish contains many other fatty acids that provide health benefits distinct from omega-3. Therefore, the immune health benefit of whole salmon oil (SO) was assessed in adults with mild to moderate COVID-19. Eleven subjects were randomized to best supportive care (BSC) with or without a full spectrum, enzymatically liberated SO, dosed at 4g daily, for twenty-eight days. Nasal swabs were taken to measure the change in gene expression of markers of immune response and showed that the SO provided both broad inflammation-resolving effects and improved interferon response. The results also suggest improved lung barrier function and enhanced immune memory, although the clinical relevance needs to be assessed in longer-duration studies. In conclusion, the salmon oil was well tolerated and provided broad inflammation-resolving effects, indicating a potential to enhance immune health.

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“…Of note, the structure included in this review has not been confirmed by Oxagen, but was characterized as OC-459 by Amira. In addition, although Pettipher et al were the first to publish a non-clinical study of OC-459, it appears that the unpublished development of OC-459 had already been undertaken by other parties [ 73 , 74 , 75 , 76 , 77 , 78 ].…”

Section: Indole-based Potential Gpr44 Analoguesmentioning

confidence: 99%

Indole-Based and Cyclopentenylindole-Based Analogues Containing Fluorine Group as Potential 18F-Labeled Positron Emission Tomography (PET) G-Protein Coupled Receptor 44 (GPR44) Tracers

Yin,

Huang,

Huang

et al. 2023

Pharmaceuticals

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Recently, growing evidence of the relationship between G-protein coupled receptor 44 (GPR44) and the inflammation-cancer system has garnered tremendous interest, while the exact role of GPR44 has not been fully elucidated. Currently, there is a strong and urgent need for the development of non-invasive in vivo GPR44 positron emission tomography (PET) radiotracers that can be used to aid the exploration of the relationship between inflammation and tumor biologic behavior. Accordingly, the choosing and radiolabeling of existing GPR44 antagonists containing a fluorine group could serve as a viable method to accelerate PET tracers development for in vivo imaging to this purpose. The present study aims to evaluate published (2000-present) indole-based and cyclopentenyl-indole-based analogues of the GPR44 antagonist to guide the development of fluorine-18 labeled PET tracers that can accurately detect inflammatory processes. The selected analogues contained a crucial fluorine nuclide and were characterized for various properties including binding affinity, selectivity, and pharmacokinetic and metabolic profile. Overall, 26 compounds with favorable to strong binding properties were identified. This review highlights the potential of GPR44 analogues for the development of PET tracers to study inflammation and cancer development and ultimately guide the development of targeted clinical therapies.

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Assessing the Anti-Inflammatory Effects of an Orally Dosed Enzymatically Liberated Fish Oil in a House Dust Model of Allergic Asthma

Cited by 5 publications

References 33 publications

Role of Cathepsin K Inhibitor & Atorvastatin in Protection Against Atherosclerosis in High Fat Diet-Fed Rats

Role of Cathepsin K Inhibitor & Atorvastatin in Protection Against Atherosclerosis in High Fat Diet-Fed Rats

Assessing the Potential of an Enzymatically Liberated Salmon Oil to Support Immune Health Recovery from Acute SARS-CoV-2 Infection via Change in the Expression of Cytokine, Chemokine and Interferon-Related Genes

Indole-Based and Cyclopentenylindole-Based Analogues Containing Fluorine Group as Potential 18F-Labeled Positron Emission Tomography (PET) G-Protein Coupled Receptor 44 (GPR44) Tracers

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