Assessing the bioavailability of polyphenols and antioxidant properties of extra virgin argan oil by simulated digestion and Caco-2 cell assays. Comparative study with extra virgin olive oil

Seiquer, Isabel; Rueda‐Robles, Ascensión; Herrera, Manuela; Cabrera–Vique, Carmen

doi:10.1016/j.foodchem.2015.05.006

Cited by 70 publications

(78 citation statements)

References 37 publications

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“…Interestingly, in the same work, that phenomenon was observed also for HTS unlike in our work indicating specific matrix effect, which is in agreement with available literature data [32]. Good GI stability of HTS, shown in our work, has already been reported by several authors [15,33,34].…”

Section: Bioaccessibility Of Olive Pomace Polyphenolssupporting

confidence: 94%

Influence of Pomace Matrix and Cyclodextrin Encapsulation on Olive Pomace Polyphenols’ Bioaccessibility and Intestinal Permeability

2020

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Olive pomace is a rich source of biologically active compounds, mainly polyphenols. Recently, an efficient and sustainable cyclodextrin (CD)-enhanced extraction was developed. It enabled a relatively simple formulation of high-quality olive pomace extracts (OPEs) that can be used as alternative sources of olive-derived polyphenols in the nutrition and pharma industries. However, biological effects and nutraceutical potential of OPEs are primarily limited by generally low oral bioavailability of major polyphenols (hydroxytyrosol and its derivatives) that can be significantly influenced by OPE matrix and the presence of CDs in formulation. The major goal of this research was to investigate the impact of complex matrix and different types of CDs on gastrointestinal stability and intestinal permeability of major OPE polyphenols, and provide additional data about mechanisms of absorption and antioxidant activity in gut lumen. Obtained results showed high bioaccessibility but relatively low permeability of OPE polyphenols, which was negatively affected by OPE matrix. CDs improved antioxidant efficiency of tested OPEs and tyrosol gastrointestinal stability. Effects of CDs on permeability and the metabolism of particular OPE polyphenols were CD-and polyphenol-specific.Nutrients 2020, 12, 669 2 of 16 oxidative stress in the intestine is particularly important given that numerous studies have shown that oxidative stress is directly linked to the development of diseases of the GI tract, such as inflammatory bowel disease and tumor colon. The intestine is the site that was shown to be extremely susceptible to oxidative stress. Namely, lipid peroxidation (as a chain reaction that lead to deleterious cell membrane damage) can be initiated by dietary fats.Considering its phenolic composition, olive pomace is very similar to olive oil and represents an inexpensive and readily available source of HTS derivatives. In the last decade, the potential of the olive pomace as a rich source of biologically active compounds has been recognized in scientific and professional literature, resulting in the development of a large number of effective extraction procedures [6,7]. However, the poor technological properties of raw olive pomace extracts (OPE) limit their wider application as nutraceuticals and food additives [7]. The main prerequisites for obtaining usable OPE are high yield of HTS derivatives, stability, and satisfactory technological properties of dry extracts. In this regard, cyclodextrins (CDs) were successfully applied for achieving higher polyphenol yields and the formulation of stable and organoleptically acceptable olive pomace extracts (OPEs) [7]. Moreover, α-CD, β-CD, and γ-CD are listed on the generally regarded as safe (GRAS) list of the U.S. Food and Drug Administration (FDA) for use as a food additive [8][9][10].In addition to demonstrating favorable chemical composition and technological properties, the quality of OPE is significantly determined by bioavailability and biological activity of its main active components...

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Section: Bioaccessibility Of Olive Pomace Polyphenolssupporting

confidence: 94%

Influence of Pomace Matrix and Cyclodextrin Encapsulation on Olive Pomace Polyphenols’ Bioaccessibility and Intestinal Permeability

2020

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“…These results agree with previous studies that found a rise of TPC and antioxidant capacity after digestion of oils Seiquer et al, 2015) and other food matrices (Arques, Pastoriza, Delgado-Andrade, Clemente, & Rufián-Henares, 2016;Pastoriza et al, 2011;Szawara-Nowak, Bą czek, & Zieliń ski, 2016), although negative effects have been also shown (Dinnella, Minichino, D'Andrea & Monteleone, 2007). Thus, our results support that in vitro digestion is a crucial step that releases a high amount of phenolic and antioxidant compounds, which seem difficult to extract from the food matrix with the solvents traditionally used (SzawaraNowak et al, 2016).…”

Section: Bioaccessible Fractionssupporting

confidence: 93%

“…For determination of ROS generation we used the dichlorofluorescin (DCFH) assay as described by Seiquer et al (2015). In presence of free radicals (ROS), the DCFH become dichlorofluorescein (DCF) and emit fluorescence; thus, quantifying fluorescence under different situations (basal conditions and oxidising conditions with t-BOOH) the ROS production may be estimated.…”

Section: Antioxidant Cell Markersmentioning

confidence: 99%

“…The Caco2 cell lines derived from human intestinal epithelial adenocarcinoma is a suitable model system for the evaluation of intestinal functions and nutrient absorption (Mesías et al, 2009;Seiquer et al, 2015). In this study, the absorption of TPC and antioxidant properties of digested oils across Caco2 cell monolayers was studied.…”

Section: Absorption Across Caco-2 Cellsmentioning

confidence: 99%

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Study of the antioxidant potential of Arbequina extra virgin olive oils from Brazil and Spain applying combined models of simulated digestion and cell culture markers

Borges

Pereira

Cabrera–Vique

et al. 2017

Journal of Functional Foods

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a b s t r a c tA physiological approach to assessing the antioxidant potential of Arbequina EVOO from different zones of Brazil and Spain was performed, applying a combined model of simulated digestion and cell cultures, using the Caco-2 cell line. Our results showed an increasing of total phenolic content (TPC) and antioxidant properties promoted by the in vitro digestion. Preincubating Caco-2 cells with bioaccessible fractions of oils counteracted the cytotoxic effect promoted by an oxidising agent (t-BOOH), preserving cell viability and reducing the generation of reactive oxygen species (ROS). The protective effect on ROS production was associated with the antioxidant activity (DPPH assay), but no relation with the TPC of the digested samples was found. Differences in the parameters evaluated were observed among the samples, which were related to climatic characteristics of the production zones. It was concluded that transformations during the digestive process are important for establishing the antioxidant potential of the oils.

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“…The active ingredients from argan oil often have a synergistic effect on health (Bester, Esterhuyse, Truter, & van Rooyen, ). The antioxidants found in argan oil should be bioavailable to express biological effects, and their bioavailability is dependent on the digestion process and on the intestinal absorption (Seiquer, Rueda, Olalla, & Cabrera‐Vique, ).…”

Section: Introductionmentioning

confidence: 99%

The impact of argan oil on plasma lipids in humans: Systematic review and meta‐analysis of randomized controlled trials

Ursoniu

Sahebkar

Şerban

et al. 2017

Phytotherapy Research

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The study aims to investigate the effect of argan oil on plasma lipid concentrations through a systematic review of the literature and a meta-analysis of available randomized controlled trials. Randomized controlled trials that investigated the impact of at least 2 weeks of supplementation with argan oil on plasma/serum concentrations of at least 1 of the main lipid parameters were eligible for inclusion. Effect size was expressed as the weighted mean difference (WMD) and 95% confidence interval (95% CI). Meta-analysis of data from 5 eligible trials with 292 participants showed a significant reduction in plasma concentrations of total cholesterol (WMD: -16.85 mg/dl, 95% CI [-25.10, -8.60], p < .001), low-density lipoprotein cholesterol (WMD: -11.67 mg/dl, 95% CI [-17.32, -6.01], p < .001), and triglycerides (WMD: -13.69 mg/dl, 95% CI [-25.80, -1.58], p = .027) after supplementation with argan oil compared with control treatment, and plasma concentrations of high-density lipoprotein cholesterol (WMD: 4.14 mg/dl, 95% CI [0.86, 7.41], p = .013) were found to be increased. Argan oil supplementation reduces total cholesterol, low-density lipoprotein cholesterol, and triglycerides and increases high-density lipoprotein cholesterol levels. Additionally, larger clinical trials are needed to assess the impact of argan oil supplementation on other indices of cardiometabolic risk and on the risk of cardiovascular outcomes.

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Assessing the bioavailability of polyphenols and antioxidant properties of extra virgin argan oil by simulated digestion and Caco-2 cell assays. Comparative study with extra virgin olive oil

Cited by 70 publications

References 37 publications

Influence of Pomace Matrix and Cyclodextrin Encapsulation on Olive Pomace Polyphenols’ Bioaccessibility and Intestinal Permeability

Influence of Pomace Matrix and Cyclodextrin Encapsulation on Olive Pomace Polyphenols’ Bioaccessibility and Intestinal Permeability

Study of the antioxidant potential of Arbequina extra virgin olive oils from Brazil and Spain applying combined models of simulated digestion and cell culture markers

The impact of argan oil on plasma lipids in humans: Systematic review and meta‐analysis of randomized controlled trials

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