IntroductionRobot-assisted laparoscopic radical prostatectomy (RALP) has been used worldwide in the treatment of localized prostate cancer because of its minimal invasiveness compared to open retropubic radical prostatectomy (RRP) (1,2). RALP provides a number of benefits, such as reduced blood loss, less postoperative pain, and shorter hospital stay than other methods. However, RALP requires a steep Trendelenburg (head-down) position and CO 2 pneumoperitoneum for several hours to secure the surgical visual field. The steep Trendelenburg position and pneumoperitoneum cause significant changes in cardiovascular, respiratory, and neurophysiological parameters (3,4). Pneumoperitoneum influences intrathoracic pressure by pushing the diaphragm upward, and the head-down position further changes the position of the intestine and diaphragm, thus reducing lung volume and decreasing respiratory system compliance.Pneumoperitoneum with head-down position also causes circulatory perturbation. The mean arterial pressure (MAP) as well as right and left ventricular filling pressures, e.g., central venous pressure and pulmonary capillary wedge pressure, increase markedly under these conditions (5).There have been several reports of anesthetic complications after RALP-a patient with post-extubation respiratory distress required reintubation and subsequent ventilation in an intensive care unit (6), a patient developed sudden pulmonary edema after uneventful RALP (7), and two patients developed postoperative ischemic optic neuropathy after RALP(8). These complications were mainly caused by steep head-down position and pneumoperitoneum during the operation.Some previous studies indicated the influence of head-down position and pneumoperitoneum on the cardiovascular and respiratory system during RALP.However, to our knowledge, the effects of different head-down angles on cardiac and respiratory function have not been determined during RALP. The present study was performed to investigate the influence of different Trendelenburg position angles with pneumoperitoneum during RALP on cardiovascular and respiratory homeostasis.
Materials and methodsApproval for the study was obtained from Institutional Ethics Committee at Kanazawa University Hospital. After obtaining written informed consent, 48 patients, who were assessed with the American Society of Anesthesiologists Physical Status (ASA PS) classification system and evaluated as ASA PS 1 or 2, were recruited. Patients with a history of valvular heart desease, myocardial infarction, chronic obstructive or restrictive pulmonary disease, heavy smoking, renal insufficiency, or neurological disease were excluded from the study. Each patient selected RRP or RALP, and 12 patients undergoing RRP and 36 patients undergoing RALP were enrolled in this study.The patients who selected RALP were randomly divided into three groups: each patient placed in the 20°, 25°, or 30° head-down position during the operation (Fig.1). But there was a concern of the sight of the operation space with a patient sele...