Assessing the dog as a model for human total hip replacement

Skurla, Carolyn; Pluhar, G. Elizabeth; Frankel, D. J.; Egger, Erick L.; James, Susan P.

doi:10.1302/0301-620x.87b1.14678

Cited by 46 publications

(23 citation statements)

References 28 publications

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“…Our steady‐state wear rate of 0.99 mg/Mc is 2.4× less than a study by Saikko et al that examined gamma cross‐linked polyethylene in human THA (irradiation dose = 95 kGy). We would have expected a greater difference in wear rates, since canine implants experience approximately 10× less load than human implant wear tests, and a previous study of postmortem‐retrieved canine hip implants found the volumetric wear rates of conventional polyethylene liners are 10× greater in humans than in canines . A potential explanation for the relatively high wear results in our study is that the surface roughness of our femoral head components ( R a = 0.77 μm; Fig.…”

Section: Discussionmentioning

confidence: 62%

“…We would have expected a greater difference in wear rates, since canine implants experience approximately 10Â less load than human implant wear tests, and a previous study of postmortem-retrieved canine hip implants found the volumetric wear rates of conventional polyethylene liners are 10Â greater in humans than in canines. 22,23 A potential explanation for the relatively high wear results in our study is that the surface roughness of our femoral head components (R a ¼ 0.77 mm; Fig. 1) was fifteen times greater than the standard roughness of femoral heads used in human studies (R a ¼ 0.05 mm).…”

Section: Canine Hip Resurfacingmentioning

confidence: 66%

“…Veterinary medicine presents a pragmatic environment to test the efficacy of using highly cross‐linked polyethylene liners that are thinner than 3.8 mm for several reasons. First, canines are highly active, and canine hip implants are considered a reasonable model for human hip implants that target younger human patients with an active lifestyle . Second, veterinary medical devices do not require pre‐market approval from the U.S. Food and Drug Administration, and therefore the iterative product development process between in vivo results and design modifications can be expedited.…”

Section: Discussionmentioning

confidence: 99%

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Wear testing of a canine hip resurfacing implant that uses highly cross‐linked polyethylene

Warburton

Everingham

Helms

et al. 2017

Journal Orthopaedic Research

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Hip resurfacing offers advantages for young, active patients afflicted with hip osteoarthritis and may also be a beneficial treatment for adult canines. Conventional hip resurfacing uses metal-on-metal bearings to preserve bone stock, but it may be feasible to use metal-on-polyethylene bearings to reduce metal wear debris while still preserving bone. This study characterized the short-term wear behavior of a novel hip resurfacing implant for canines that uses a 1.5 mm thick liner of highly cross-linked polyethylene in the acetabular component. This implant was tested in an orbital bearing machine that simulated canine gait for 1.1 million cycles. Wear of the liner was evaluated using gravimetric analysis and by measuring wear depth with an optical scanner. The liners had a steady-state mass wear rate of 0.99 ± 0.17 mg per million cycles and an average wear depth in the central liner region of 0.028 mm. No liners, shells, or femoral heads had any catastrophic failure due to yielding or fracture. These results suggest that the thin liners will not prematurely crack after implantation in canines. This is the first hip resurfacing device developed for canines, and this study is the first to characterize the in vitro wear of highly cross-linked polyethylene liners in a hip resurfacing implant. The canine implant developed in this study may be an attractive treatment option for canines afflicted with hip osteoarthritis, and since canines are the preferred animal model for human hip replacement, this implant can support the development of metal-on-polyethylene hip resurfacing technology for human patients. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1196-1205, 2018.

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Section: Discussionmentioning

confidence: 62%

Section: Canine Hip Resurfacingmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

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Wear testing of a canine hip resurfacing implant that uses highly cross‐linked polyethylene

Warburton

Everingham

Helms

et al. 2017

Journal Orthopaedic Research

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“…In each dog, there was failure at the bone–cement interface and in 2 dogs fracture (structural failure) of the PMMA. Furthermore, aseptic loosening is one of the most commonly reported complications in cemented THA often leading to implant failure 5,29–31 …”

Section: Discussionmentioning

confidence: 99%

Revision of Cemented Total Hip Arthroplasty with Cementless Components in Three Dogs

Torres

Budsberg

2008

Veterinary Surgery

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“…To date, the availability of bone cements has been limited to non-resorbable materials that are comprised of polymethylmethacrylate, used commonly for the cementation of implants such as total hip replacements (22,23). Infection (24) and adhesive failure (25) are inherent risks with materials not removed or resorbed.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical Testing of a Calcium Phosphate-Phosphoserine–Based Mineral-Organic Adhesive for Non-invasive Fracture Repair of Mandibular Fractures in Dogs

et al. 2020

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Mandibular fracture repair is complicated by limited availability of bone as well as the presence of the neurovascular bundle and an abundance of tooth roots. Fractures at the location of the mandibular first molar teeth are common and it can be particularly challenging to apply stable fixation. Non-invasive fracture repair techniques utilize intraoral placement of fixation devices typically involving polymerized composites and/or interdental wiring. A novel calcium phosphate-phosphoserine-based mineral-organic adhesive was tested ex vivo to determine its effects on augmenting strength of different non-invasive fracture fixation techniques. This study both tested the use of mineral-organic adhesive for the purpose of stabilizing currently used noninvasive fracture repair constructs (intraoral composite splinting ± interdental wiring) and evaluated adhesive alone or with subperiosteally placed plates on buccal cortical bone surface. Aside from controls, not receiving an osteotomy along the mesial root of the mandibular first molar tooth, six treatment groups were tested to evaluate ultimate strength, stiffness, angular displacement, bending moment, and application time. All forms of fixation were found to be significantly weaker than control (p < 0.001). Only the control (p < 0.001) and mineral-organic adhesive and composite (P = 0.002) groups were found to be significantly stronger than wire and composite. No difference was noted in stiffness between any groups with control or wire and composite. Application times varied from the mineral-organic adhesive group (mean = 206 s) to mineral-organic adhesive and composite (mean = 1,281 s). Twenty-three fixation devices exhibited adhesive failure, 20 demonstrated cohesive failure, and 5 failed by cohesive and adhesive failure. When evaluating the ultimate strength of the fixation device groups, mineral-organic adhesive, and composite was shown to be the strongest construct. The use of resorbable bone adhesive and composite may provide a stronger fixation construct over interdental wire and composite for mandibular fracture repair in dogs.

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Assessing the dog as a model for human total hip replacement

Cited by 46 publications

References 28 publications

Wear testing of a canine hip resurfacing implant that uses highly cross‐linked polyethylene

Wear testing of a canine hip resurfacing implant that uses highly cross‐linked polyethylene

Revision of Cemented Total Hip Arthroplasty with Cementless Components in Three Dogs

Biomechanical Testing of a Calcium Phosphate-Phosphoserine–Based Mineral-Organic Adhesive for Non-invasive Fracture Repair of Mandibular Fractures in Dogs

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