Analysing municipal solid waste (MSW) management scenarios is relevant for planning future policies and actions toward a circular economy. Life cycle assessment (LCA) is appropriate for evaluating technologies of MSW treatment and their environmental impacts. However, in developing countries, advanced assessments are di cult to introduce due to the lack of technical knowledge, data, and nancial support. This research aims to assess the main potentialities of the introduction of waste-to-energy (WtE) systems in a developing Argentinean urban area taking into account the existing regulations about MSW recycling goals. The study was conducted with WRATE software and the proposed scenarios were: current management, grate incineration of raw MSW, incineration of solid recovered fuel (SRF). In addition, a sensitivity analysis on the energy matrix was included. It was found that the production of SRF allows increasing the energy generation from waste by 200% and reducing the environmental impact of about 10% regarding the current MSW management system. Acidi cation Potential and Abiotic Depletion Potential were sensitive to changes in electricity mix. Results showed that if MSW reduction goals are achieved, changes in MSW composition will affect the performance of WtE plants and, in some cases, they will be not technically feasible. The outcomes of this study can be of interest for developing countries stakeholders, and practitioners interested in LCA and sustainable MSW management.