Assessing the impact of one million COVID-19 deaths in America: economic and life expectancy losses

Silva, Sachin; Goosby, Eric; Reid, Michael

doi:10.1038/s41598-023-30077-1

Cited by 22 publications

(15 citation statements)

References 22 publications

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“…This result well matched the reality that the global economy suffered a significant negative decline during 2020 and 2021. In terms of work by Silva et al [ 43 ], the U.S. life expectancy at birth dropped by 3.08 years due to the million COVID-19 deaths. Economic welfare losses were estimated to be USD 3.57 trillion.…”

Section: Resultsmentioning

confidence: 99%

Can Stringent Government Initiatives Lead to Global Economic Recovery Rapidly during the COVID-19 Epidemic?

Zhang

et al. 2023

IJERPH

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This paper investigates the effectiveness of government measures implemented against COVID-19 and the factors influencing a country’s economic growth from a global perspective. With the help of the data of the Government Response Stringency Index (GRSI), Google mobility, and confirmed COVID-19 daily cases, we conducted a panel model for 105 countries and regions from 11 March 2020 to 31 June 2021 to explore the effects of response policies in different countries against the pandemic. First, the results showed that staying in residential places had the strongest correlation with confirmed cases. Second, in countries with higher government stringency, stay-at-home policies carried out in the early spread of the pandemic had the most effective the impact. In addition, the results have also been strictly robustly analyzed by applying the propensity score matching (PSM) method. Third, after reconstructing a panel data of 47 OECD countries, we further concluded that governments should take stricter restrictive measures in response to COVID-19. Even though it may also cause a shock to the market in the short term, this may not be sustainable. As long as the policy response is justified, it will moderate the negative effect on the economy over time, and finally have a positive effect.

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Section: Resultsmentioning

confidence: 99%

Can Stringent Government Initiatives Lead to Global Economic Recovery Rapidly during the COVID-19 Epidemic?

Zhang

et al. 2023

IJERPH

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“…A previous study conducted by the Advanced Highway Maintenance and Construction Technology (AHMCT) Research Center [20] reported that the average fatal accident rate in California during maintenance activities from 1972 to 2013 was 2.18×10 -7 deaths per person-hour of work on the road [21]. To compute the cost of worker fatality as a result of a car collision into the work zone, we used the most recent Valuation of a Statistical Life (VSL) published by the U.S. Department of Transportation [22,23], which reports the VSL using the base year of 2022 as equal to $12.5 million [22]. Employing the VSL and average fatal accidents, we computed the cost of workers' fatality resulting from a car collision into the work zone to be equal to $2.57 per person-hour of work.…”

Section: Workers' Fatalitymentioning

confidence: 99%

Lifetime Cost Analysis of Concrete Barriers and Steel Guardrails

Nemati,

Haas,

Torick

et al. 2024

Preprint

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This study investigates the lifetime costs associated with concrete barriers and steel guardrails. We introduce a cost analysis methodology that incorporates critical factors such as construction costs, maintenance costs, exposure risks during maintenance activities, and the costs imposed to traveling public through the increased traffic and the crash outcomes. We integrate various parameters including economic factors, road geometry, general weather condition, and traffic mix to estimate a location-dependent cost for each type of barrier accurately. A software tool, named CalBarrier, was developed during this study to carry out the calculations and the comparison of lifetime cost of aforementioned barriers. An inherent strength of this research is its reliance on recent real data extracted from various databases of California Department of Transportation (Caltrans), ensuring precision and relevance in accounting for various influential factors. Drawing insights from Caltrans practices and interviews with their personnel, this study emphasizes the intricate decision-making process involved in mitigating safety risks and reducing operational expenses. Although our data originates from California, the methodology for life cycle cost analysis, and our software are applicable for regions with different socio-economic conditions by adjusting the baseline costs, making our findings a valuable resource for other areas facing comparable challenges.

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“…The COVID-19 pandemic, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-COV-2), is responsible for a vast amount of deaths and economic disruption across the globe . Despite the development and approval of vaccines, − and the antiviral drug Paxlovid, which targets the SARS-COV-2 virus, COVID-19 continues to spread and remains a severe health risk, particularly for people with underlying conditions .…”

Section: Introductionmentioning

confidence: 99%

Allosteric Inhibitors of the SARS-COV-2 Papain-like Protease Domain Induce Proteasomal Degradation of Its Parent Protein NSP3

Cockram,

Walters,

Lictao

et al. 2023

ACS Chem. Biol.

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The papain-like protease of SARS-COV-2 is essential for viral replication and pathogenesis. Its location within a much larger multifunctional protein, NSP3, makes it an ideal candidate for a targeted degradation approach capable of eliminating multiple functions with a single-molecule treatment. In this work, we have developed a HiBiT-based cellular model to study NSP3 degradation and used this platform for the discovery of monovalent NSP3 degraders. We present previously unreported degradation activity of published papain-like protease inhibitors. Follow-up exploration of structure−activity relationships and mechanism-of-action studies points to the recruitment of the ubiquitin-proteasome machinery that is solely driven by site occupancy, regardless of molecular features of the ligand. Supported by HDX data, we hypothesize that binding-induced structural changes in NSP3 trigger the recruitment of an E3 ligase and lead to proteasomal degradation.

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Assessing the impact of one million COVID-19 deaths in America: economic and life expectancy losses

Cited by 22 publications

References 22 publications

Can Stringent Government Initiatives Lead to Global Economic Recovery Rapidly during the COVID-19 Epidemic?

Can Stringent Government Initiatives Lead to Global Economic Recovery Rapidly during the COVID-19 Epidemic?

Lifetime Cost Analysis of Concrete Barriers and Steel Guardrails

Allosteric Inhibitors of the SARS-COV-2 Papain-like Protease Domain Induce Proteasomal Degradation of Its Parent Protein NSP3

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