Assessing the Prognostic Importance of ER, PR Expression in Meningiomas by Comparing with Proliferative Rate Using Ki67

Shanthi, Vissa; Grandhi, Bhavana; Rao, Nandam Mohan; Rao, Byna Syam Sundar; Reddy, Vijaya Lakshmi Muram

doi:10.21088/ijprp.2278.148x.62(pt-ii)17.16

Cited by 3 publications

(4 citation statements)

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“…1 . In our study, the most common histopathological variant was transitional meningioma (76.50%), similar to the results published by Babu et al, Grondahl et al, Veeramani et al and Shanthi et al 14,[19][20][21] All these authors had reported transitional meningioma as the most common variant in their studies. In our study, 93.05% cases were grade I, totally in concordance to the existing literature.…”

Section: Discussionsupporting

confidence: 91%

Histopathological Mapping of Meningiomas: A 10-year Retrospective Analysis

Pant

Chaturvedi

Sarma

et al. 2021

Indian Journal of Neurosurgery

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Background Meningiomas are a group of neoplasms showing a spectrum of histopathological variants, mostly corresponding to World Health Organization (WHO) grade I. However, certain histologic variants correspond histologically to WHO grades II and III. In this study, the histopathological spectrum of the meningiomas received in our department over the past 10 years is being revisited, with the aim to analyze the various histopathological variants, in order to assess their grade as per WHO 2016 criteria and also assess their epidemiology and localization. Materials and Methods A retrospective analysis of the histopathology records and clinical case files was done in 302 cases of histopathologically diagnosed cases of intracranial/intraspinal meningiomas (WHO grade I, II and III) received over a period of 10 years in our department. Hematoxylin and eosin (HE) staining was done for histological typing and grading of the tumors, and the cases were analyzed as per WHO 2016 criterion. Age and sex distribution along with the localization of the 302 cases was also analyzed. Results Among these, grade I meningiomas (93.05%) were the most common. According to histopathological type, transitional meningioma (76.50%) was the most common. Maximum cases were located at the cerebral convexities, reported in the fifth decade with a female preponderance. Conclusion As per WHO 2016, grade I meningiomas are associated with low-risk of recurrence and aggressive behavior, while WHO grade II and III meningiomas are associated with greater likelihood of recurrence and aggressive behavior. This classification itself summarizes the importance of accurate typing and grading of meningiomas on histopathology.

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Section: Discussionsupporting

confidence: 91%

Histopathological Mapping of Meningiomas: A 10-year Retrospective Analysis

Pant

Chaturvedi

Sarma

et al. 2021

Indian Journal of Neurosurgery

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“… 16 However, this progesterone expression is not under the influence of the estrogen as in reproductive organs. 9 12 17 Meningothelial cells primarily line the edges of arachnoid granulation so-called arachnoid cap cells, 18 and this arachnoid granulation plays a role in the absorption of cerebrospinal fluid into dural sinuses. 17 19 The role of PR in the regulation of the fluid transportation is not yet clear, but there are some indications that steroid hormones can play a role in which glucocorticoid dexamethasone is reported to increase the absorption of cerebrospinal fluid into the sagittal sinus.…”

Section: Discussionmentioning

confidence: 99%

Progesterone Receptor Expression and Score Differences in Determining Grade and Subtype of Meningioma

Poniman

Cangara

Kaelan

et al. 2020

JNRP

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Background Meningioma is the most common brain tumor in which therapy and monitoring depend on the histopathological grade (World Health Organization [WHO] Grade). Progesterone receptor (PR) expression was reported positive in meningothelial cells and meningiomas with various degrees of positivity. We evaluated PR expression to determine its correlation with WHO Grade and each subtype of meningioma. Materials and Methods This study used 70 samples of paraffin block that were diagnosed as meningioma and classified into WHO Grade I, II, and III. The paraffin blocks were sectioned in 5 µm thickness and immunohistochemically stained with the anti-PR antibody. Results PR expression was found positive in WHO Grade I and II groups, but negative in WHO Grade III group with the score of +2 found in clear cell and atypical subtype. These results were statistically significant with p-value < 0.05. Conclusion PR can be used as an additional marker to determine WHO Grade and subtype of meningioma.

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“…Hormone receptors in meningiomas were first described by Donnel et al in 1979 using receptor binding assays. [3,4] Since then, many authors have studied the relation between sex hormone receptors and meningiomas. [5][6][7][8][9][10][11] It is assumed that sex steroid hormones may influence the growth of meningiomas because of higher incidence of meningiomas among women, their behaviour during pregnancy, and the reported epidemiological link between meningiomas and breast carcinomas.…”

Section: Discussionmentioning

confidence: 99%

“…Walter et al [32] has shown that preoperative administration of medroxy progesterone in patients with meningiomas that have positive PR receptors would show better clinical response when compared to patients who had tumor cells that were without PR receptors. Vissa shanthi et al [4] found that the tumors with high proliferative activity showed low PR expression. They proposed that though surgery is the treatment for the meningiomas, in some cases where tumor is not accessible to surgery or in elderly patients or in malignant tumors where complete removal is not possible due to invasion into the adjacent structures, antiprogesterone agents can be used in addition to radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Hormone Receptor Status and KI67 Proliferation Index in Meningiomas

B¹,

Shanmugam²,

Niamath³

et al. 2020

APALM

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Background:Meningiomas are the most common extra-axial tumours of central nervous system arising from arachnoidal cap cells. The biological behaviour of these tumours is unpredictable because of the tendency of these tumours to recur irrespective of the grade. However, WHO grading is the most useful morphological predictor of recurrence. Additional prognostic parameters like Ki67 proliferation index and progesterone receptor status are useful in predicting the risk of recurrence. This study was undertaken to evaluate the spectrum of Ki67 proliferation index in various grades of meningiomas and to correlate these findings with the hormone receptor status.Methods: In this study 225 cases of meningiomas, over 6 yrs period, were studied which included grade 1 and grade 2 meningiomas. The relation between Grade, Ki67 proliferation index and progesterone receptor status was studied. Result:We found a significant positive correlation between grade and Ki67 proliferation index at 0.01 level and significant negative correlation between Grade and progesterone receptor status at 0.05 level. There was also significant negative correlation between progesterone receptor status and Ki67 proliferation index in cases with progesterone receptor staining score of 6 to 12. Many of the grade 1 meningiomas also showed a higher Ki67 proliferation index Conclusion:In this study we conclude that, PR and Ki67 Proliferation index are useful supplements of routine histopathological assessment of meningiomas and can be used as prognostic indicators regarding behavior and response to treatment.

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Assessing the Prognostic Importance of ER, PR Expression in Meningiomas by Comparing with Proliferative Rate Using Ki67

Cited by 3 publications

References 0 publications

Histopathological Mapping of Meningiomas: A 10-year Retrospective Analysis

Histopathological Mapping of Meningiomas: A 10-year Retrospective Analysis

Progesterone Receptor Expression and Score Differences in Determining Grade and Subtype of Meningioma

Hormone Receptor Status and KI67 Proliferation Index in Meningiomas

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